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Genes (261)
Species: human : 207 mouse : 54 | |
Mouse | BACH2 | 60468 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | Bach2 is a B-cell- and neuron-specific transcription repressor that forms heterodimers with the Maf-related oncoproteins. Bach1 and Bach2 repress MARE-dependent transcription by forming heterodimers with Maf-related oncoproteins. Bach2 is an Nrf2-related transcription repressor and a tissue-specific partner of the Maf oncoprotein family. | Mouse | SH3GLB1 | 51100 | SH3-domain GRB2-like endophilin B1 | Nevertheless, when compared with the combined human ACs, 39 genes with similar expression changes in murine lung tumors and human ACs/LCCs were identified, such as the oncogene-related BCL7B, the cell cycle regulator CDK4, and the proapoptotic Endophilin B1. | Mouse | GPR132 | 29933 | G protein-coupled receptor 132 | Click here to display 6 evidence detail records. | Mouse | BBC3 | 27113 | BCL2 binding component 3 | Like p53 shRNAs, PUMA shRNAs promoted oncogenic transformation of primary murine fibroblasts by the E1A/ras oncogene combination and dramatically accelerated myc-induced lymphomagenesis without disrupting p53-dependent cell-cycle arrest. | Mouse | TMEM158 | 25907 | transmembrane protein 158 (gene/pseudogene) | Finally, Ris1-deficient embryonic fibroblasts were indistinguishable from wild-type cells regarding their proliferation properties, immortalization, senescence and oncogenic transformation. | Mouse | CDC37 | 11140 | cell division cycle 37 | The oncoprotein kinase chaperone CDC37 functions as an oncogene in mice and collaborates with both c-myc and cyclin D1 in transformation of multiple tissues. These data indicate that CDC37 can function as an oncogene in mice and suggests that the establishment of protein kinase pathways mediated by Cdc37-Hsp90 can be a rate-limiting event in epithelial cell transformation. | Mouse | SERINC3 | 10955 | serine incorporator 3 | Ligation-mediated PCR analysis showed integration sites near or within established protooncogenes (Chd9, Slamf6, Tde1, Camk2b, and Ly6e), demonstrating that T cell transformation was associated with targeting of oncogene loci; however, no integrations within the Lmo2 locus were identified. | Mouse | OLIG2 | 10215 | oligodendrocyte lineage transcription factor 2 | Ectopic OLIG2 expression in the thymus was only weakly oncogenic as only 2 of 85 mice developed pre-T LBL. | Mouse | ABI1 | 10006 | abl-interactor 1 | A novel cellular protein, Abl-interactor-1 (Abi-1), which specifically interacts with the carboxy-terminal region of Abl oncoproteins, has been identified in a mouse leukemia cell line. | Mouse | DMTF1 | 9988 | cyclin D binding myb-like transcription factor 1 | Early-passage DMP1-null cells, like MEFs from either ARF-null or p53-null mice, can be morphologically transformed by oncogenic Ha-Ras (Val-12) alone. | Mouse | AKAP12 | 9590 | A kinase (PRKA) anchor protein 12 | We showed previously that the tetracycline-regulated reexpression of the Src-suppressed C kinase substrate (SSeCKS, also known as Gravin/AKAP12) inhibited variables of v-Src-induced oncogenic growth in NIH3T3, correlating with the induction of normal actin cytoskeletal structures and cell morphology but not with gross inhibition of Src phosphorylation activity in the cell. | Mouse | HYAL2 | 8692 | hyaluronoglucosaminidase 2 | Oncogenic transformation assays using mouse and rat fibroblasts have localized the transforming activity to the Env proteins encoded by these viruses, which require the putative lung and breast cancer tumor suppressor hyaluronidase 2 (Hyal2) to promote virus entry into cells. | Mouse | BCAS1 | 8537 | breast carcinoma amplified sequence 1 | Finally, overexpression of human NABC1 in mouse NIH/3T3 cells did not affect either the growth rate or anchorage-dependent growth properties, suggesting that NABC1 is not a prototypical oncogene. | Mouse | RECK | 8434 | reversion-inducing-cysteine-rich protein with kazal motifs | One of the elements responsible for the oncogene-mediated downregulation of mouse RECK gene is the Sp1 site, where the Sp1 and Sp3 factors bind. RECK was first isolated as a transformation suppressor gene by cDNA expression cloning in a mouse fibroblast cell line transformed by an activated RAS oncogene. Oncogene-mediated downregulation of RECK, a novel transformation suppressor gene. | Mouse | HMGA2 | 8091 | high mobility group AT-hook 2 | Its activated form (HMGA 2/T) presents oncogenic activities both in vivo and in vitro. | Mouse | MLLT10 | 8028 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | Similarly, the minimal oncogenic domain of AF10 exhibited transcriptional activation properties when fused to the MLL or GAL4 DNA-binding domains, while neither helical domain alone did. | Mouse | CSDE1 | 7812 | cold shock domain containing E1, RNA-binding | The absence of mutations of the N-ras codons 12, 13, 18, and 61 suggests that activation of the proto-oncogene is exclusively due to overexpression by retroviral promoter insertion, and furthermore, Northern blot analyses indicate that the expression of unr is unaffected by N-ras overexpression even in the case where the unr gene itself is the target of proviral insertion. | Mouse | EZR | 7430 | ezrin | When, in the oncogenic Raf-1-transfected mouse hepatic cell line, epithelial to mesenchymal transition (EMT) indicated as down-regulation of E-cadherin and up-regulation of Snail occurred, loss of microvilli and down-regulation of ezrin but not radixin and moesin were also observed. | Mouse | TLE1 | 7088 | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) | Grg1 acts as a lung-specific oncogene in a transgenic mouse model. | Mouse | TBX3 | 6926 | T-box 3 | We show that expression of Tbx3 together with Myc or oncogenic Ras (H-Ras(Val17)) leads to efficient transformation of mouse embryo fibroblasts. Oncogene cooperation by Tbx3 correlates with an ability of Tbx3 to suppress the induction of p19ARF and p53 that is typically caused by overexpression Myc and Ras, and to protect against Myc-induced apoptosis. Our results support the idea that deregulation and/or excessive levels of Tbx3 may have oncogenic potential in vivo. | Mouse | TAL2 | 6887 | T-cell acute lymphocytic leukemia 2 | The leukemic oncogene tal-2 is expressed in the developing mouse brain. tal-1 (T-cell acute leukemia-1; also known as SCL) and tal-2 genes belong to a family of basic helix-loop-helix transcription factors and were originally isolated from the breakpoints of chromosomal translocations in human T-cell leukemia cell lines. tal-1 is expressed not only in hematopoietic cells but also in several endothelial structures and the central nervous system during development. | Mouse | ROBO1 | 6091 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | Furthermore, we have shown that many of the genes involved in lung development are either known oncogenes or tumour suppressor genes altered in lung cancer, such as Cyr61, Rassf1a, and Dutt1/Robo1, or putative lung cancer genes. | Mouse | RAP1B | 5908 | RAP1B, member of RAS oncogene family | These experiments provide conclusive evidence that Rap1b is oncogenic in the thyroid in ways linked to transduction of the cAMP mitogenic signal. cAMP-dependent oncogenic action of Rap1b in the thyroid gland. cAMP signaling leads to activation and phosphorylation of Rap1b. | Mouse | PLK1 | 5347 | polo-like kinase 1 | Here we report that microinjection of Plk mRNA is sufficient to drive quiescent cells into mitosis and that constitutive expression of Plk in NIH 3T3 cells causes oncogenic focus formation. | Mouse | PAX3 | 5077 | paired box 3 | Click here to display 7 evidence detail records. |
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