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Details
Link-It Detail - Disease - Oncogenes
Debug Stats
  • ### Total Build Time: 119 ms 57.795 KB
  • CONCEPT_NAME gt=12 ms Completed: 12 ms rowSize= 316 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 686 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 183 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=0 Completed: 0 ms rowSize= 7 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 15 bytes
  • CONCEPT_RELATIONSHIPS gt=38 ms Completed: 38 ms rowSize= 13.716 KB
  • CONCEPT_GENES gt=68 ms Completed: 68 ms rowSize= 41.722 KB
  • CONCEPT_XREFS gt=1 ms Completed: 1 ms rowSize= 1.144 KB
  • CONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Oncogenes C0029016
Definition (1)
Genes whose gain-of-function alterations lead to NEOPLASTIC CELL TRANSFORMATION. They include, for example, genes for activators or stimulators of CELL PROLIFERATION such as growth factors, growth factor receptors, protein kinases, signal transducers, nuclear phosphoproteins, and transcription factors. A prefix of "v-" before oncogene symbols indicates oncogenes captured and transmitted by RETROVIRUSES; the prefix "c-" before the gene symbol of an oncogene indicates it is the cellular homolog (PROTO-ONCOGENES) of a v-oncogene.
Semantic Types (1)
Gene or Genome (T028)
Relationships (107)

Relation Types:
gene_​to_​chem : 55
gene_​to_​diso : 29
gene_​to_​gene : 8
gene_​to_​phen : 2
gene_​to_​phys : 13


Relationships:
none : 69
gene_​product_​encoded_​by_​gene : 30
isa : 5
mapped_​to : 1
permuted_​term_​of : 1
process_​involves_​gene : 1
Page Size
Current 25
  Page 1 of 5
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
GENE_to_PHEN192img genetic aspects C0017399
GENE_to_PHEN149img genetic aspects C0017399
GENE_to_DISO125img Neoplasms C0027651
GENE_to_PHYS112img physiological aspects C0031843
GENE_to_DISO103img Neoplasms C0027651
GENE_to_PHYS77img physiological aspects C0031843
GENE_to_DISO75img CELL TRANSFORM NEOPL C0007621
GENE_to_GENE74img Genes, Tumor Suppressor C0079427
GENE_to_PHYS67img GENE EXPRESSION REG NEOPL C0017268
GENE_to_GENE56img Genes, Tumor Suppressor C0079427
GENE_to_PHYS52img Mutation C0026882
GENE_to_CHEM50img MicroRNAs C1101610
GENE_to_PHYS41img GENE EXPRESSION REG NEOPL C0017268
GENE_to_PHYS41img Signal Transduction C0037083
GENE_to_DISO39img CELL TRANSFORM NEOPL C0007621
GENE_to_DISO38img Breast Neoplasms C1458155
GENE_to_PHYS32img Aging, Cell C0007581
GENE_to_DISO30img Lung Neoplasms C0024121
GENE_to_CHEM29img Binding Protein, DNA C0012940
GENE_to_CHEM26img Nuclear Proteins C0028589
GENE_to_CHEM26img TRANSCRIPTION FACTOR C0040648
GENE_to_PHYS22img Apoptosis C0162638
GENE_to_PHYS22img Gene Amplification C0017256
GENE_to_CHEM21img E30-E34 ONCOGENE PROTEINS C0029005
GENE_to_CHEM20img Proteins, Tumor Suppressor C0597611
Genes (261)

Species:
human : 207
mouse : 54
Page Size
Current 25
  Page 1 of 11
Prior Page
Current 1
SpeciesGeneGeneIdGene NameEvidence
MouseBACH260468BTB and CNC homology 1, basic leucine zipper transcription factor 2
img NCI, Score=801, Pubmed Id: 10669750, UMLKSK CUI: C0029016
img NCI, Score=801, Pubmed Id: 11530014, UMLKSK CUI: C0029016
img NCI, Score=801, Pubmed Id: 10809773, UMLKSK CUI: C0029016
MouseSH3GLB151100SH3-domain GRB2-like endophilin B1
img NCI, Score=801, Pubmed Id: 14647414, UMLKSK CUI: C0029016
MouseGPR13229933G protein-coupled receptor 132
Click here to display 6 evidence detail records.
MouseBBC327113BCL2 binding component 3
img NCI, Score=801, Pubmed Id: 15192153, UMLKSK CUI: C0029016
MouseTMEM15825907transmembrane protein 158 (gene/pseudogene)
img NCI, Score=801, Pubmed Id: 16964279, UMLKSK CUI: C0029016
MouseCDC3711140cell division cycle 37
img NCI, Score=801, Pubmed Id: 10825210, UMLKSK CUI: C0029016
img NCI, Score=801, Pubmed Id: 10825210, UMLKSK CUI: C0029016
MouseSERINC310955serine incorporator 3
img NCI, Score=801, Pubmed Id: 16864781, UMLKSK CUI: C0029016
MouseOLIG210215oligodendrocyte lineage transcription factor 2
img NCI, Score=801, Pubmed Id: 16103065, UMLKSK CUI: C0029016
MouseABI110006abl-interactor 1
img NCI, Score=801, Pubmed Id: 7590237, UMLKSK CUI: C0029016
MouseDMTF19988cyclin D binding myb-like transcription factor 1
img NCI, Score=801, Pubmed Id: 10898794, UMLKSK CUI: C0029016
MouseAKAP129590A kinase (PRKA) anchor protein 12
img NCI, Score=801, Pubmed Id: 16547152, UMLKSK CUI: C0029016
MouseHYAL28692hyaluronoglucosaminidase 2
img NCI, Score=801, Pubmed Id: 12584308, UMLKSK CUI: C0029016
MouseBCAS18537breast carcinoma amplified sequence 1
img NCI, Score=801, Pubmed Id: 14567997, UMLKSK CUI: C0029016
MouseRECK8434reversion-inducing-cysteine-rich protein with kazal motifs
img NCI, Score=801, Pubmed Id: 10454749, UMLKSK CUI: C0029016
img NCI, Score=801, Pubmed Id: 12784995, UMLKSK CUI: C0029016
img NCI, Score=801, Pubmed Id: 10454749, UMLKSK CUI: C0029016
MouseHMGA28091high mobility group AT-hook 2
img NCI, Score=801, Pubmed Id: 16007198, UMLKSK CUI: C0029016
MouseMLLT108028myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
img NCI, Score=801, Pubmed Id: 11986236, UMLKSK CUI: C0029016
MouseCSDE17812cold shock domain containing E1, RNA-binding
img NCI, Score=801, Pubmed Id: 11689675, UMLKSK CUI: C0029016
MouseEZR7430ezrin
img NCI, Score=801, Pubmed Id: 16274688, UMLKSK CUI: C0029016
MouseTLE17088transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
img NCI, Score=801, Pubmed Id: 16452182, UMLKSK CUI: C0029016
MouseTBX36926T-box 3
img NCI, Score=801, Pubmed Id: 12032820, UMLKSK CUI: C0029016
img NCI, Score=801, Pubmed Id: 12032820, UMLKSK CUI: C0029016
img NCI, Score=801, Pubmed Id: 12032820, UMLKSK CUI: C0029016
MouseTAL26887T-cell acute lymphocytic leukemia 2
img NCI, Score=801, Pubmed Id: 9931488, UMLKSK CUI: C0029016
MouseROBO16091roundabout, axon guidance receptor, homolog 1 (Drosophila)
img NCI, Score=801, Pubmed Id: 12807961, UMLKSK CUI: C0029016
MouseRAP1B5908RAP1B, member of RAS oncogene family
img NCI, Score=801, Pubmed Id: 15331589, UMLKSK CUI: C0029016
img NCI, Score=801, Pubmed Id: 15331589, UMLKSK CUI: C0029016
MousePLK15347polo-like kinase 1
img NCI, Score=801, Pubmed Id: 9177283, UMLKSK CUI: C0029016
MousePAX35077paired box 3
Click here to display 7 evidence detail records.
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0029016Oncogenes0self