Human | PTPRVP | 148713 | protein tyrosine phosphatase, receptor type, V, pseudogene | In this study, we measured human endolymphatic sac potential (ESP) in 8 patients with vestibular schwannoma and in five patients with Ménière;s disease during surgery. |
Human | IL23A | 51561 | interleukin 23, alpha subunit p19 | INFERRED, Score=800, UMLKSK CUI: C0027859 |
Human | RASSF1 | 11186 | Ras association (RalGDS/AF-6) domain family member 1 | hypermethylation of RASSF1A was associated with negative cyclin D1 expression in a series of 21 vestibular schwannomas |
Human | SCG2 | 7857 | secretogranin II | INFERRED, Score=800, UMLKSK CUI: C0027859 |
Human | WT2 | 7491 | Wilms tumor 2 | CONCLUSIONS: This study has demonstrated that (1) chromosome 22 allele loss is a frequent event in sporadic acoustic neuroma; (2) the minimal region of loss of heterozygosity in acoustic neuroma includes the NF2 gene; (3) the known tumor suppressor genes investigated (VHL, adenomatous polyposis coli, WT2, p53, and NF1) do not appear to be important in the pathogenesis of acoustic neuroma; and (4) patients with extensive chromosome 22 loss tended to be younger and with a slightly shorter clinical history than those with no detectable allele loss. |
Human | EZR | 7430 | ezrin | INFERRED, Score=800, UMLKSK CUI: C0027859 |
Human | TP53 | 7157 | tumor protein p53 | age dependent phosphorylation of p53 protein and deregulation of p53 gene has a role in the development of human vestibular schwannomas |
Human | TFRC | 7037 | transferrin receptor (p90, CD71) | Epidermal growth factor receptor (EGFR) and transferrin receptor levels were determined in 14 intracranial neoplasms (four glioblastomas multiforme, four medulloblastomas, four ependymomas, one cerebellar astrocytoma, and one acoustic neurinoma) and in four samples of ;normal; brain tissue. |
Human | SYP | 6855 | synaptophysin | INFERRED, Score=800, UMLKSK CUI: C0027859 |
Human | SSTR1 | 6751 | somatostatin receptor 1 | METHODS: The expression of SSTRs 1, 2, 3, and 5 was studied in both the Schwann cells and blood vessels of eight acoustic neuroma specimens, by means of immunohistochemistry using novel rabbit polyclonal antibodies raised against human SSTR 1, 2, and 5 subtype specific peptides, and a commercial anti-SSTR3 antibody. |
Human | RB1 | 5925 | retinoblastoma 1 | RB1 gene has a major role in the development of human vestibular schwannomas, increased levels of RB1 mRNA, total pRb and the phosphorylated form of it suggests that RB1 gene in these tumors may have anti-apoptotic function |
Human | NF2 | 4771 | neurofibromin 2 (merlin) | Click here to display 19 evidence detail records. |
Human | MAP3K11 | 4296 | mitogen-activated protein kinase kinase kinase 11 | INFERRED, Score=800, UMLKSK CUI: C0027859 |
Human | KRAS | 3845 | Kirsten rat sarcoma viral oncogene homolog | |
Human | HRAS | 3265 | Harvey rat sarcoma viral oncogene homolog | |
Human | ERBB2 | 2064 | v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 | we have shown an increased expression of ErbB-2 vestibular schwannomas |
Human | EGFR | 1956 | epidermal growth factor receptor | These findings implicate the ErbB pathway in vestibular schwannoma growth we have shown no expression of ErbB-1 in vestibular schwannomas |
Human | CHGB | 1114 | chromogranin B (secretogranin 1) | INFERRED, Score=800, UMLKSK CUI: C0027859 |
Human | CHAT | 1103 | choline O-acetyltransferase | Pre- and postoperative CSF obtained from a patient with acoustic neurinoma enhanced the proliferation of astrocytes in neuronal cell cultures derived from embryonic rat cortex grown in serum-free defined medium, and increased choline acetyltransferase activity of cholinergic neurons derived from embryonic rat septal area and brainstem. |
Human | CDKN1B | 1027 | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | Aggressive acoustic neuromas show postoperative rapid growth and a decreased association with p27 expression |
Human | ALAD | 210 | aminolevulinate dehydratase | ALAD genotype was determined for 94% of these samples (355 glioma, 151 meningioma, 67 acoustic neuroma, and 505 controls). |
Human | ABCA2 | 20 | ATP-binding cassette, sub-family A (ABC1), member 2 | Expression of ABCA2 protein in human vestibular schwannoma and peripheral nerve. |