|Mouse||GREM2||64388||gremlin 2, DAN family BMP antagonist|
PRDC gene product shows limited similarities to the products of DAN (differential screening-selected gene aberrative in neuroblastoma) and cerberus.
|Mouse||BACH2||60468||BTB and CNC homology 1, basic leucine zipper transcription factor 2|
Bach2 is involved in neuronal differentiation of N1E-115 neuroblastoma cells.
|Mouse||CADM3||57863||cell adhesion molecule 3|
Like the human TSLL1, the mouse Tsll1 was expressed exclusively in the brain and neurogenic cells, while Tsll1 expression was lost in one of four rodent neuroblastoma cell lines.
|Mouse||DMAP1||55929||DNA methyltransferase 1 associated protein 1|
A recombinant GGL domain of RGS6 precipitated endogenous DMAP1 and Dnmt1 in neuroblastoma cell lysates and endogenous DMAP1 co-immunoprecipitated with RGS6L from mouse brain.
|Mouse||CEND1||51286||cell cycle exit and neuronal differentiation 1|
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|Mouse||METAP2||10988||methionyl aminopeptidase 2|
We previously showed that the antiangiogenic compound TNP-470, an irreversible methionine aminopeptidase 2 (MetAP2) inhibitor, suppressed local and disseminated human neuroblastoma growth rates in murine models but had significant associated toxicity at the effective dose.
|Mouse||WASF1||8936||WAS protein family, member 1|
It also provides the first steps towards the development of mouse models for the role of the WAVE genes in actin and cytoskeleton organization in general, and in the development of neuroblastoma in particular.
|Mouse||PDE5A||8654||phosphodiesterase 5A, cGMP-specific|
The antibody is able to immunoprecipitate PDE5 activity from mouse tissues and neuroblastoma extracts while it has no effect on all other PDE isoforms present in the extracts.
|Mouse||KHSRP||8570||KH-type splicing regulatory protein|
In normally cultured neuroblastoma cells, these src RNA foci contain PTB, but little KSRP.
|Mouse||GAS7||8522||growth arrest-specific 7|
Conversely, GAS7 overexpression in undifferentiated neuroblastoma cell cultures dramatically promotes neurite-like outgrowth.
|Mouse||TIMP3||7078||TIMP metallopeptidase inhibitor 3|
Retroviral vector-producer cell-mediated in vivo gene transfer of TIMP-3 restricts angiogenesis and neuroblastoma growth in mice.
|Mouse||TCOF1||6949||Treacher Collins-Franceschetti syndrome 1|
Inhibition of Tcof1 expression by siRNA induced morphological changes in neuroblastoma cells that mimic differentiation.
We also showed that the level of Tcof1 and treacle expression is downregulated during differentiation of neuroblastoma cells into neuronal cells.
|Mouse||CX3CL1||6376||chemokine (C-X3-C motif) ligand 1|
Fractalkine gene therapy for neuroblastoma is more effective in combination with targeted IL-2.
|Mouse||RGS16||6004||regulator of G-protein signaling 16|
Combined, rather than individual, inhibition of DUSP6 and RGS16 was required to block retinoid-induced growth inhibition in neuroblastoma cells, through phosphorylation of extracellular-signal-regulated kinase.
|Mouse||RBL2||5934||retinoblastoma-like 2 (p130)|
The RB-related gene Rb2/p130 in neuroblastoma differentiation and in B-myb promoter down-regulation.
From comparison of HSS patterns in these cell lines with those of neuroblastoma cells, it can be predicted that HSS located in the region -1500/+800 bp participate in cell-specific expression of the mouse peripherin gene.
In particular, we have identified a 70-bp element [peripherin cytokine-responsive element (Pe-CyRE)] within the 5;-flanking sequences of the mouse peripherin gene (between -930 and -860) that enhances transcription in two neuroblastoma cell lines, NBFL and LA-N-2, in response to LIF treatment.
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|Mouse||PRKAA1||5562||protein kinase, AMP-activated, alpha 1 catalytic subunit|
Here, we investigated the effect of the AMPK activator 5-aminoimidazole-4-carboxamide-ribonucleoside (AICAR) on oxidative stress-induced apoptosis using mouse Neuro 2a neuroblastoma cells.
|Mouse||PPIA||5478||peptidylprolyl isomerase A (cyclophilin A)|
Cyclosporin A regulates the levels of cyclophilin A in neuroblastoma cells in culture.
|Mouse||PDGFRB||5159||platelet-derived growth factor receptor, beta polypeptide|
RESULTS: All seven neuroblastoma cell lines treated with imatinib displayed concentration-dependent decreases in cell viability, which coincided with an induction of apoptosis, and with ligand-stimulated phosphorylation of c-Kit and PDGFR.
We therefore evaluated the effects of imatinib mesylate (imatinib), a selective inhibitor of the tyrosine kinase activities of c-Kit and PDGFR, on the growth of neuroblastoma cells in vivo and in vitro.
|Mouse||OPRM1||4988||opioid receptor, mu 1|
The present study demonstrates a conditional, agonist-dependent phosphorylation of the mu-opioid receptor (MOR-1) by cyclic AMP-dependent protein kinase (PKA) in membrane preparations of MOR-1-transfected neuroblastoma Neuro2A cells.
|Mouse||NEUROD2||4761||neuronal differentiation 2|
Transient expression of NeuroD2, one of neural bHLH transcription factors, converted mouse N1E-115 neuroblastoma cells into differentiated neurons.
|Mouse||NDN||4692||necdin, melanoma antigen (MAGE) family member|
Here we demonstrate that ectopic expression of necdin induces a neuronal phenotype in neuroblastoma cells.
Among various established cell lines including neuroblastoma and glioma cells, only differentiated embryonal carcinoma cells (P19 and F9) expressed necdin mRNA.
|Mouse||MYCN||4613||v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog|
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|Mouse||JUND||3727||jun D proto-oncogene|
In this paper, we show that neuronal differentiation of mouse N1E-115 neuroblastoma cells by dimethyl sulfoxide is accompanied by a prolonged rise in c-jun, junB, and junD expression and AP-1 activity.