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Genes (223)
Species: human : 210 mouse : 13 | |
Mouse | CTHRC1 | 115908 | collagen triple helix repeat containing 1 | In 75% of Cthrc1 transgenic mice, cartilaginous metaplasia of medial smooth muscle cells was observed as assessed by Alcian blue staining and expression of the chondrocyte marker collagen type II. | Mouse | KLF4 | 9314 | Kruppel-like factor 4 (gut) | Klf4 mutants also display aberrant expression of acidic mucins and TFF2/SP-positive cells, findings characteristic of premalignant conditions, but no inflammation, intestinal metaplasia, dysplasia, or cancer up to 1 year of age. | Mouse | TP63 | 8626 | tumor protein p63 | P63 was also essential for uterine squamous metaplasia induced by DES-exposure. | Mouse | WNT10B | 7480 | wingless-type MMTV integration site family, member 10B | Wnt10b and Int2 transgenes also induced squamous metaplasias, but expression of CK1 and CK6 was sporadic. | Mouse | TFF2 | 7032 | trefoil factor 2 | Thus, TFF2 is an allergen-induced gene, which is expressed in mucus-positive airways, but is not a major contributor to allergen-induced goblet cell metaplasia, mucus production, or inflammatory responses in the lung. These results suggest that SP/TFF2 does not impact on the development of metaplasia after the induction of parietal cell loss. Furthermore, the loss of TFF2 did not affect induction or resolution of mucus cell metaplasia as measured by periodic acid-Schiff (PAS) or alcian blue staining. After 7 days of treatment in wild-type mice, a second proliferative population emerged at the base of fundic glands along with the development of a mucous cell metaplasia expressing TFF2/spasmolytic polypeptide (SPEM). | Mouse | SELPLG | 6404 | selectin P ligand | Administration of both PSGL-1 and PS/2 had the additive effect of eliminating eosinophils from the airways (96% decrease), with few or no additional reductions (relative to PS/2 administration alone) in lymphocyte recruitment, mucous cell metaplasia, or AHR. | Mouse | MUC5AC | 4586 | mucin 5AC, oligomeric mucus/gel-forming | NE induced Muc5ac mRNA and protein expression and goblet cell metaplasia on days 8, 11, and 14. These cellular changes were the result of proteolytic activity, since the addition of an elastase inhibitor, methoxysuccinyl Ala-Ala-Pro-Val chloromethylketone (AAPV-CMK), blocked NE-induced Muc5ac expression and goblet cell metaplasia. | Mouse | MCF2 | 4168 | MCF.2 cell line derived transforming sequence | Thus, although the dbl oncogene did not induce neoplasia in any of the mice studied, it is apparently capable of interfering with the ability of the lens epithelial cells to differentiate into lens fiber cells, and of inducing metaplasia of the epithelial cells into fibroblastic cells. | Mouse | IVL | 3713 | involucrin | RESULTS: The virus transfected cells showed squamous metaplasia when they were injected into severe combined immunodeficient mice, expressing the high molecular weight keratin (Moll;s number 1 keratin) and involucrin molecules immunohistochemically, and involucrin and transglutaminase I mRNAs by RT-PCR. | Mouse | IL13 | 3596 | interleukin 13 | Click here to display 6 evidence detail records. | Mouse | IL6ST | 3572 | interleukin 6 signal transducer (gp130, oncostatin M receptor) | However, unlike mice with null mutations in any of the components in the gp130 signaling pathway, gp130(DeltaSTAT) mice also displayed gastrointestinal ulceration and a severe joint disease with features of chronic synovitis, cartilaginous metaplasia, and degradation of the articular cartilage. | Mouse | HBEGF | 1839 | heparin-binding EGF-like growth factor | Overexpression of heparin-binding EGF-like growth factor in mouse pancreas results in fibrosis and epithelial metaplasia. | Mouse | CDX1 | 1044 | caudal type homeobox 1 | Cdx1 induced intestinal metaplasia in the transgenic mouse stomach: comparative study with Cdx2 transgenic mice. CONCLUSIONS: We have confirmed that Cdx1 induced gastric intestinal metaplasia but that it differed from Cdx2 induced intestinal metaplasia in differentiation, structure, and proliferation. | Human | GGT2 | 728441 | gamma-glutamyltransferase 2 | These findings merit further exploration to document the extent of the expression of GGT in bronchogenic cancer and to attempt to explain its presence in alveolar cell metaplasia. Compared with regular squamous metaplasia, dysplastic-neoplastic lesions showed much stronger reaction for GGT and lectins; normal and hyperplastic mucociliary epithelium showed intermediate reactions. | Human | MUC5B | 727897 | mucin 5B, oligomeric mucus/gel-forming | Furthermore, overexpression of MUC5AC, MUC5B and MUC2 correlates strongly with secretory cell hyperplasia and metaplasia in human and murine airways. MUC5AC and MUC5B are expressed in the same histological pattern in CF compared to normal tissues with an increase of MUC5AC-positive cells due to goblet cell hyper- and metaplasia. | Human | ARMS2 | 387715 | age-related maculopathy susceptibility 2 | INFERRED, Score=800, UMLKSK CUI: C0025568 | Human | GCRG224 | 360219 | GCRG-P224 | In situ hybridization analysis showed that only 5/30 adenocarcinoma, 3/18 dysplasia and 6/18 intestinal metaplasia showed higher GCRG224 expression level than the normal gastric glands. | Human | PSORS1C2 | 170680 | psoriasis susceptibility 1 candidate 2 | A small proline-rich protein, SPR1, is overexpressed in squamous metaplasia of bronchial epithelium. | Human | REM2 | 161253 | RAS (RAD and GEM)-like GTP binding 2 | INFERRED, Score=800, UMLKSK CUI: C0025568 | Human | HIST4H4 | 121504 | histone cluster 4, H4 | Reduced expression of acetylated histone H4 was also observed in some areas of intestinal metaplasia adjacent to carcinomas. | Human | REG4 | 83998 | regenerating islet-derived family, member 4 | In the stomach, foveolar epithelium was negative for Reg IV, whereas goblet cells of intestinal metaplasia and neuroendocrine cells at the base of intestinal metaplasia expressed Reg IV. In the stomach, foveolar epithelium was negative for Reg IV, whereas goblet cells of intestinal metaplasia and neuroendocrine cells at the base of intestinal metaplasia expressed Reg IV. | Human | JAM3 | 83700 | junctional adhesion molecule 3 | INFERRED, Score=800, UMLKSK CUI: C0025568 | Human | NAA15 | 80155 | N(alpha)-acetyltransferase 15, NatA auxiliary subunit | INFERRED, Score=800, UMLKSK CUI: C0025568 | Human | XYLT2 | 64132 | xylosyltransferase II | INFERRED, Score=800, UMLKSK CUI: C0025568 | Human | XYLT1 | 64131 | xylosyltransferase I | INFERRED, Score=800, UMLKSK CUI: C0025568 |
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