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Genes (17)
Species: human : 17 | |
Human | TLR4 | 7099 | toll-like receptor 4 | Title:Human toll-like receptor 4 mutations are associated with susceptibility to invasive meningococcal disease in infancy.|Association:Y|Conclusion:We conclude that TLR4 mutations represent a risk factor for meningococcal disease in this age group. | Human | SFTPA2B | 6436 | | Gene polymorphism resulting in the substitution of glutamine with lysine at residue 223 in the carbohydrate recognition domain of SP-A2 increases susceptibility to meningococcal disease, as well as the risk of death The role of SFTPA2 polymorphism in meningococcal disease risk is presented | Human | SERPINE1 | 5054 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | there is a correlation between the 4G4G genotype of the PAI-1 gene and development of disseminated intravascular coagulation in meningococcal infection the 4G/5G insertion/deletion promoter polymorphism, which leads to differences in PAI-1 production, has been demonstrated to affect risk of developing severe complications and dying from sepsis during meningococcal infection and multiple trauma [review] Title:Role of functional plasminogen-activator-inhibitor-1 4G/5G promoter polymorphism in susceptibility, severity, and outcome of meningococcal disease in Caucasian children.|Association:Y|Conclusion:This study confirms that Caucasian pediatric patients carrying the functional PAI-1 4G/4G genotype are at an increased risk of developing vascular complications and dying from meningococcal disease. Title:4G/5G promoter polymorphism in the plasminogen-activator-inhibitor-1 gene in children with systemic meningococcaemia.|Association:Y|Conclusion:Our data show a correlation between the 4G/4G genotype in the plasminogen activator inhibitor-1 gene and poor outcome in children with meningococcal infection. In addition, 4G homozygous patients were prone to develop sepsis. We found no influence of the plasminogen activator inhibitor-1 polymorphism on the susceptibility to invasive meningococcal infection. | Human | MIF | 4282 | macrophage migration inhibitory factor (glycosylation-inhibiting factor) | MIF is increased in patients with meningococcal disease and highest in the presence of shock | Human | CD46 | 4179 | CD46 molecule, complement regulatory protein | role in meningococcal disease; results suggest that CD46 facilitates pilus-dependent interactions at the epithelial mucosa | Human | MBL2 | 4153 | mannose-binding lectin (protein C) 2, soluble | MBL exon 1 structural variants are significantly associated with susceptibility to childhood meningococcal disease in an age-dependent manner | Human | IL10 | 3586 | interleukin 10 | Title:Relevance of Fcgamma receptor and interleukin-10 polymorphisms for meningococcal disease.|Association:Not Found|Conclusion:These data provide further evidence for the association of polymorphic genes on chromosome 1 and meningococcal disease. | Human | IL1RN | 3557 | interleukin 1 receptor antagonist | Title:An interleukin-1 genotype is associated with fatal outcome of meningococcal disease.|Association:Y|Conclusion:There was no association between TNF genotype and fatal outcome. These data suggest that IL-1 genotype influences the severity of meningococcal disease. | Human | IL1A | 3552 | interleukin 1, alpha | Title:|Association:Y|Conclusion:Not Found | Human | FCGR3B | 2215 | Fc fragment of IgG, low affinity IIIb, receptor (CD16b) | Title:Relevance of Fcgamma receptor and interleukin-10 polymorphisms for meningococcal disease.|Association:Not Found|Conclusion:These data provide further evidence for the association of polymorphic genes on chromosome 1 and meningococcal disease. | Human | FCGR3A | 2214 | Fc fragment of IgG, low affinity IIIa, receptor (CD16a) | Title:Relevance of Fcgamma receptor and interleukin-10 polymorphisms for meningococcal disease.|Association:Not Found|Conclusion:These data provide further evidence for the association of polymorphic genes on chromosome 1 and meningococcal disease. | Human | FCGR2A | 2212 | Fc fragment of IgG, low affinity IIa, receptor (CD32) | Title:Associations between Fc gamma receptor IIA polymorphisms and the risk and prognosis of meningococcal disease.|Association:Y|Conclusion:The FcgammaRIIA-R/R131 allotype is associated with more severe forms of meningococcal disease. Title:Relevance of Fcgamma receptor and interleukin-10 polymorphisms for meningococcal disease.|Association:Not Found|Conclusion:These data provide further evidence for the association of polymorphic genes on chromosome 1 and meningococcal disease. | Human | CPB2 | 1361 | carboxypeptidase B2 (plasma) | prevalence of the Thr325Ile dimorphism in the TAFI gene in 50 patients who survived meningococcal disease, in 176 first-degree relatives of a consecutive patient series with meningococcal disease and 212 controls from the same geographic region | Human | C7 | 730 | complement component 7 | recurrence of fulminant meningococcal disease in a complement component C7-deficient patient | Human | C6 | 729 | complement component 6 | The most common defect, which leads to an increased susceptibility to Neisseria meningitidis infections in the Western Cape, is 879delG | Human | CEACAM1 | 634 | carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) | Haplotypic diversity in CEACAM genes: effects on susceptibility to meningococcal disease | Human | CFB | 629 | complement factor B | a novel role of properdin in AP complement initiation and have implications for understanding the selective predisposition of properdin-deficient patients to meningococcal infection |
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