Human | DHFRL1 | 200895 | dihydrofolate reductase-like 1 | The results of this study suggest that genetic variants of methionine metabolism are associated with meningioma formation |
Human | TMEM30B | 161291 | transmembrane protein 30B | Human CDC50A mRNA was expressed in embryonic stem (ES) cells, placenta, brain and chondrosarcoma, while CDC50B mRNA was expressed in pancreatic islet, kidney, prostate as well as in lung carcinoid, parathyroid tumor, bladder tumor, meningioma and pancreatic cancer. |
Human | SAT2 | 112483 | spermidine/spermine N1-acetyltransferase family member 2 | In order to establish a possible correlation between ganglioside expression in brain tumor and the activities of the enzymes involved in their metabolism, we analyzed the activities of specific sialyltransferases (SAT-1 and SAT-2), galactosyltransferase (GalT-4), N-acetylgalactosaminyltransferase (GalNAcT-1), and N-acetylglucosaminyltransferase (GlcNAcT-1) in 9 human meningiomas whose ganglioside pattern was characterized either by the predominance ganglioside GM3 (4 out of 9) or ganglioside GD3 (5 out of 9). |
Human | RRP36 | 88745 | ribosomal RNA processing 36 homolog (S. cerevisiae) | More than 80% of meningioma patients had antibodies against at least one of the antigens KIAA1344, SC65, SOX2, and C6orf153. |
Human | MMP25 | 64386 | matrix metallopeptidase 25 | MT6-MMP was also detected at high levels in SW480 colon carcinoma cells as well as in some anaplastic astrocytomas and glioblastomas, but not in normal colon or brain or in meningiomas. |
Human | TXNDC16 | 57544 | thioredoxin domain containing 16 | More than 80% of meningioma patients had antibodies against at least one of the antigens KIAA1344, SC65, SOX2, and C6orf153. |
Human | NDRG2 | 57447 | NDRG family member 2 | Click here to display 6 evidence detail records. |
Human | SOX6 | 55553 | SRY (sex determining region Y)-box 6 | In contrast, ependymal tumors (ependymoma and subependymoma), meningioma, and schwannoma, which are all well differentiated tumors, showed either no staining or only faint staining for SOX6. |
Human | MEG3 | 55384 | maternally expressed 3 (non-protein coding) | Genomic analysis revealed that MEG3 is located on chromosome 14q32.3, a site that has been predicted to contain a tumor suppressor gene involved in the pathogenesis of meningiomas. |
Human | ST7L | 54879 | suppression of tumorigenicity 7 like | Because allelic loss or rearrangements of human chromosome 1p13 region are reported in breast cancer, germ cell tumors, squamous cell carcinoma of head and neck, non-small cell lung cancer, gastrointestinal stromal/smooth muscle tumors (GIST), meningioma, melanoma, acute megakaryoblastic leukemia (M7), and Kaposi;s sarcoma, ST7R might be a novel tumor suppressor gene on human chromosome 1p13. |
Human | HPGDS | 27306 | hematopoietic prostaglandin D synthase | Click here to display 8 evidence detail records. |
Human | PTPN22 | 26191 | protein tyrosine phosphatase, non-receptor type 22 (lymphoid) | It is unclear if there is a direct association between LyP and meningiomas. |
Human | CADM1 | 23705 | cell adhesion molecule 1 | Click here to display 7 evidence detail records. |
Human | EPB41L3 | 23136 | erythrocyte membrane protein band 4.1-like 3 | Click here to display 19 evidence detail records. |
Human | RASSF1 | 11186 | Ras association (RalGDS/AF-6) domain family member 1 | genetic alterations in the methylation status of p73 or RASSF1A along with 1p LOH may result in the malignant transformation of a meningioma |
Human | DSTN | 11034 | destrin (actin depolymerizing factor) | Actin depolymerizing factor and the organization and distribution of actin in astrocytomas and meningiomas. |
Human | ADAM28 | 10863 | ADAM metallopeptidase domain 28 | In this work, we have examined the expression level and the methylation status of the 5; upstream region of the adhesion molecule ADAM23 in two brain tumor cell lines (A172 and T98G) as well as in three primary brain tumors (one grade II astrocytoma and two meningiomas) and 15 glioblastoma xenografts. |
Human | MGEA5 | 10724 | meningioma expressed antigen 5 (hyaluronidase) | None of the human genes, however, showed any homology at the nucleotide or amino acid sequence level to the newly isolated antigen we termed meningioma expressed antigen 5 (MGEA5). MGEA5 was originally identified to be a novel human hyaluronidase, which is immunogenic in meningioma patients. Reverse transcription (RT)-PCR and northern blot hybridization revealed expression of the gene encoding MGEA5 in several meningioma and additional human tissues. |
Human | IGF2BP1 | 10642 | insulin-like growth factor 2 mRNA binding protein 1 | CRD-BP expression has also been detected in benign tumors such as breast fibroadenomas, meningiomas and other benign mesenchymal tumors, implying a role for this gene in abnormal cell proliferation. The highest frequency (60%) of CRD-BP positive tumors was observed in meningiomas, either benign (11/18) or atypical (3/3). highest frequency of CRD-BP positive tumors was observed in meningiomas |
Human | NCOA2 | 10499 | nuclear receptor coactivator 2 | Using Western blot analysis and immunohistochemistry, we demonstrate the expression of the steroid coactivators steroid receptor cofactor (SRC-1), amplified in breast cancer protein (AIB1), and transcriptional intermediary factor 2 (TIF2) in 81, 76, and 76% of meningiomas, respectively. |
Human | YAP1 | 10413 | Yes-associated protein 1 | results represent the first demonstration that merlin regulates cell growth in meningioma cells by suppressing YAP |
Human | MSLN | 10232 | mesothelin | These findings suggest that mesothelin is expressed in at least some arachnoid and meningioma cells |
Human | OLIG2 | 10215 | oligodendrocyte lineage transcription factor 2 | We investigated the expression of OLIG2 by in-situ hybridisation in 21 brain tumours: nine grade II and III oligodendrogliomas, three grade II oligoastrocytomas, and nine non-oligodendroglial tumours (four grade IV astrocytomas, two meningiomas, a dysembryoplastic neuroepithelial tumour, and two metastases). |
Human | MVP | 9961 | major vault protein | Click here to display 6 evidence detail records. |
Human | TSC22D1 | 8848 | TSC22 domain family, member 1 | Complete lack of expression of TSC-22 occurred in one sample of anaplastic astrocytoma, as well as in meningioma, brain sarcoma, sarcomatous meningioma, and oligodendroglioma. |