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Genes (186)
Species: human : 173 mouse : 13 | |
Mouse | XRCC5 | 7520 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | Thus, p53-mediated neuronal apoptosis likely suppresses medulloblastoma in Ku80-deleted mice and Ku80 likely suppresses medulloblastoma by repairing nonspecific DNA DSBs instead of Rag-specific DSBs. Ku80 and p53 suppress medulloblastoma that arise independent of Rag-1-induced DSBs. | Mouse | XRCC4 | 7518 | X-ray repair complementing defective repair in Chinese hamster cells 4 | XRCC4 suppresses medulloblastomas with recurrent translocations in p53-deficient mice. | Mouse | STAT2 | 6773 | signal transducer and activator of transcription 2, 113kDa | Surprisingly, these animals developed either more severe and accelerated neurodegeneration with calcification and inflammation (GIFN/STAT1 deficient) or severe immunoinflammation and medulloblastoma (GIFN/STAT2 deficient). | Mouse | SHH | 6469 | sonic hedgehog | We conclude that nestin-expressing neural progenitors, present in the cerebellum at birth, can act as the cells-of-origin for medulloblastoma, and that c-Myc cooperates with Shh to enhance tumorigenicity. | Mouse | MAPK7 | 5598 | mitogen-activated protein kinase 7 | Overexpression of both ERK5 and MEF2 induced a statistically significant increase in cell death of neurotrophin-3-responsive and nonresponsive medulloblastoma cell lines (Daoy-trkC and Daoy) and primary cultures of patched heterozygous mouse medulloblastomas. | Mouse | PAX3 | 5077 | paired box 3 | Overexpression of murine Pax3 into a human medulloblastoma cell line (DAOY) resulted in an increase in NCAM polysialylation and a 2-4-fold increase in alpha2, 8-polysialyltransferase type II mRNA levels. Overexpression of murine Pax3 increases NCAM polysialylation in a human medulloblastoma cell line. | Mouse | NTRK3 | 4916 | neurotrophic tyrosine kinase, receptor, type 3 | Like human medulloblastomas, mouse tumors with reduced levels of the neurotrophin-3 receptor, trkC/Ntrk3, display decreased apoptosis in vivo, illustrating the role of TrkC in regulating tumor cell survival. | Mouse | LIG4 | 3981 | ligase IV, DNA, ATP-dependent | DNA ligase IV suppresses medulloblastoma formation. In mice, Ptc1 haploinsufficiency and disruption of DNA repair (DNA ligase IV inactivation) or cell cycle regulation (Kip1, Ink4d, or Ink4c inactivation), in conjunction with p53 dysfunction, predispose to medulloblastoma. | Mouse | GLI2 | 2736 | GLI family zinc finger 2 | These results demonstrate that Gli1 plays a central role in medulloblastoma formation in Ptc1(+/-) mice and that Gli2 may also contribute to oncogenesis.Oncogene (2005) 24, 4026-4036. Interestingly, Gli2 levels were elevated in medulloblastoma cells but not in normal granule neuron precursors during cerebellar development in mice lacking Gli1. | Mouse | GLI1 | 2735 | GLI family zinc finger 1 | Click here to display 6 evidence detail records. | Mouse | CDKN2C | 1031 | cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) | Click here to display 6 evidence detail records. | Mouse | ATOH1 | 474 | atonal homolog 1 (Drosophila) | However, 21 genes were specifically up-regulated in medulloblastoma, including sFrp1, Ptc2, and Math1, members of signaling pathways that regulate cerebellar development. | Mouse | PARP1 | 142 | poly (ADP-ribose) polymerase 1 | Here we show that disruption of poly(ADP-ribose) polymerase (PARP-1) causes a high incidence (49%) of aggressive brain tumors in p53 null mice, with typical features of human cerebellar medulloblastomas. | Human | MIR124-1 | 406907 | | CDK6 is regulated by microRNA 124 in medulloblastoma and that miR 124 modulates medulloblastoma cell growth | Human | KCTD11 | 147040 | potassium channel tetramerization domain containing 11 | Here we report that REN, a putative tumor suppressor frequently deleted in human medulloblastoma, is expressed to a higher extent in nonproliferating inner EGL and IGL granule cells than in highly proliferating outer EGL cells. Results identify REN(KCTD11) as a suppressor of Hedgehog signaling and suggest that its inactivation might lead to a deregulation of the tumor-promoting Hedgehog pathway in medulloblastoma | Human | TMEM200A | 114801 | transmembrane protein 200A | Frequent detection of reduced expression of AK091351 and KIAA1913 genes implicates them as suppressors of medulloblastoma tumorigenesis. | Human | CDCA7 | 83879 | cell division cycle associated 7 | As tumor-specific JPO1 expression in human and murine medulloblastoma has also been reported; these collective observations suggest important functional links between the novel JPO protein family and c-Myc in medulloblastoma transformation. | Human | PTBP2 | 58155 | polypyrimidine tract binding protein 2 | In this paper we examine the specific cellular distribution of PTB expression in normal brain (n = 2) and tumors of various types (low-grade astrocytoma, n = 2; anaplastic astrocytoma, n = 2; glioblastoma, n = 4; medulloblastoma, n = 4; central neurocytoma, n = 2; dysplastic gangliocytoma, n = 1; ganglioglioma, n = 1; paraganglioma, n = 1). | Human | CTNNBIP1 | 56998 | catenin, beta interacting protein 1 | presentation of medulloblastoma in two siblings (one of each sex) and their great-uncle; immunostaining for gene products in medulloblastoma differed in the two siblings for beta-catenin and was similar with staining for gli | Human | SEPT3 | 55964 | septin 3 | SEPT3 was expressed in medulloblastoma specimens and cell lines, but not in astrocytoma specimens or cell lines. | Human | SOX6 | 55553 | SRY (sex determining region Y)-box 6 | Immunohistochemical analysis revealed that astrocytic and oligodendroglial tumors expressed SOX6; neuronal-glial cell tumors (central neurocytoma) and embryonal tumors (medulloblastoma), which arise from multipotential stem cell precursors, also showed a high intensity of SOX6 staining. | Human | PINX1 | 54984 | PIN2/TERF1 interacting, telomerase inhibitor 1 | Click here to display 6 evidence detail records. | Human | SUFU | 51684 | suppressor of fused homolog (Drosophila) | Click here to display 9 evidence detail records. | Human | DNAJC15 | 29103 | DnaJ (Hsp40) homolog, subfamily C, member 15 | evidence of MCJ hypermethylation in intracranial primitive neuroectodermal tumours (PNETs) (medulloblastomas, supratentorial PNETs & ependymomas); data indicate epigenetic inactivation of MCJ may play a role in development of pediatric brain tumours | Human | CADM1 | 23705 | cell adhesion molecule 1 | The remaining genes studied showed either low frequency methylation (p14(ARF), p16(INK4a), RIZ1; <7% of cases), no evidence of methylation (p15(INK4b), TIMP3, TP73, TSLC1), or comparable patterns of methylation in the normal cerebellum (EDNRB), suggesting that their hypermethylation does not play a major role in medulloblastoma. To assess the role of aberrant epigenetic events in medulloblastoma and identify critical genes in its development, we profiled the promoter methylation status of 11 candidate tumour-suppressor genes (TSGs; p14(ARF), p15(INK4b), p16(INK4a), CASP8, HIC1, EDNRB, TIMP3, TP73, TSLC1, RIZ1 and RASSF1A) in medulloblastoma cell lines, primary tumours and the normal cerebellum. |
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