Human | MIR25 | 407014 | microRNA 25 | Suggest that the miR-106b-25 cluster is involved in E2F1 posttranscriptional regulation and may play a key role in the development of TGFbeta resistance in gastric cancer |
Human | MIR21 | 406991 | microRNA 21 | miR-21 was overexpressed in 92% (34/37) of the gastric cancer samples examined findings suggest a potential regulatory pathway in which H. pylori infection upregulates expression of miR-21, which in turn downregulates RECK, and then leads to the development of gastric cancer |
Human | MIR16-1 | 406950 | | Human miR-16 microRNA could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2 |
Human | MIR15A | 406948 | microRNA 15a | Human miR-15 microRNA could play a role in the development of MDR in gastric cancer cells at least in part by modulation of apoptosis via targeting BCL2 |
Human | FLCN | 201163 | folliculin | Findings show that the BHD gene is a rare target in microsatellite instability (MSI)-high gastric cancer, and BHD mutation tends to occur downstream in the mutational events of other major MSI-high target genes |
Human | NEWENTRY | 192343 | Record to support submission of GeneRIFs for a gene not in Gene (human; man). | results demonstrate that in p53-deficient human gastric cancer cells, restoration of functional miR-34 inhibits cell growth and induces chemosensitization and apoptosis, indicating that miR-34 may restore p53 function[MIRN34] |
Human | DNAJB1P1 | 171221 | DnaJ (Hsp40) homolog, subfamily B, member 1 pseudogene 1 | Overexpressed in gastric cancer |
Human | DDX53 | 168400 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 | results suggest that the methylation status of the CpG sites of CAGE determines its expression, and that hypomethylation of CAGE precedes the development of gastric cancer and hepatocellular carcinoma |
Human | GATA5 | 140628 | GATA binding protein 5 | in colorectal cancer and gastric cancer promoter hypermethylation and transcriptional silencing are frequent for GATA-4 and -5 |
Human | CLDN23 | 137075 | claudin 23 | characterization of CLDN23 gene, a candidate tumor suppressor gene implicated in intestinal-type gastric cancer |
Human | DCBLD2 | 131566 | discoidin, CUB and LCCL domain containing 2 | These data suggest that down-regulation of DCBLD2, often associated with promoter hypermethylation, is a frequent event that may be related to the development of gastric cancer |
Human | B4GALNT2 | 124872 | beta-1,4-N-acetyl-galactosaminyl transferase 2 | Epigenetic changes in a group of glycosyltransferases including B4GALNT2 and ST3GAL6 represent a malignant phenotype of gastric cancer caused by silencing of the activity of these enzymes |
Human | LRRC3B | 116135 | leucine rich repeat containing 3B | suggest that LRRC3B is a putative tumor suppressor gene that is silenced in gastric cancers by epigenetic mechanisms and that LRRC3B silencing in cancer may play an important role in tumor escape from immune surveillance |
Human | TP53INP1 | 94241 | tumor protein p53 inducible nuclear protein 1 | TP53INP1 protein negativity is significantly associated with aggressive pathological phenotypes of gastric cancer The p53DINP1 mRna expression in the antral mucosa was significantly lower in the gastric cancer patients than in the chronic gastritis patients |
Human | PGAP3 | 93210 | post-GPI attachment to proteins 3 | MGC9753, consisting of eight exons, clustered with PPP1R1B, STARD3, TCAP, PNMT, ERBB2, MGC14832 and GRB7 genes within the 120-kb region of chromosome 17q12; PPP1R1B, STARD3, MGC9753, ERBB2 and GRB7 genes are co-amplified in several cases of gastric cancer |
Human | TSPYL5 | 85453 | TSPY-like 5 | aberrant methylation at a CpG island of TSPYL5 may play an important role in development of gastric cancers |
Human | TNS4 | 84951 | tensin 4 | TNS4 mRNA expression was significantly higher in gastric cancer |
Human | PPP1R1B | 84152 | protein phosphatase 1, regulatory (inhibitor) subunit 1B | The up-regulation of ZNRD1 significantly inhibited the drug sensitivity of gastric cancer cells over-expressing DARPP-32, indicating that ZNRD1 may be important in the DARPP-32-mediated MDR of gastric cancer DARPP-32 mediates multidrug resistance of gastric cancer through regulation of P-gp and ZNRD1 overexpression of DARPP-32 is associated with gastric cancer |
Human | REG4 | 83998 | regenerating islet-derived family, member 4 | RegIV expression was markedly higher in gastric cancer patients with peritoneal metastases compared to those without; level of RegIV mRNA in gastric cancer patients was related to the extent of wall penetration |
Human | DYNLRB1 | 83658 | dynein, light chain, roadblock-type 1 | Infrequently mutated in human colorectal and gastric cancers |
Human | MYCT1 | 80177 | myc target 1 | MTLC was down-regulated in the majority of gastric cancer tissues and could promote apoptosis of GC cell lines, which suggests that MTLC may play an important role in the carcinogenesis of gastric carcinoma |
Human | NEIL1 | 79661 | nei endonuclease VIII-like 1 (E. coli) | Reduced expression of NEIL1 is associated with the pathogenesis of gastric cancers |
Human | ADIPOR2 | 79602 | adiponectin receptor 2 | Adiponectin negatively regulates the progression of gastric cancer cells possibly through AdipoR2 |
Human | AICDA | 57379 | activation-induced cytidine deaminase | Aberrant expression of activation-induced cytidine deaminase may contribute to the development of gastric cancers and induce p53 nuclear expression |
Human | CIAPIN1 | 57019 | cytokine induced apoptosis inhibitor 1 | CIAPIN1 is a suppressor of gastric cancer cell proliferation; CIAPIN1 might play an important role in the development of human gastric cancer it is concluded that CIAPIN1 confers multidrug resistance in gastric cancer cells, likely by upregulating MDR-1 and MRP-1 |