Human | COL18A1 | 80781 | collagen, type XVIII, alpha 1 | Accumulation of endostatin/collagenXVIII in brains of patients who died with cerebral malaria |
Human | HAVCR1 | 26762 | hepatitis A virus cellular receptor 1 | The present results suggest that the higher TIM1 expression associated with the protective TIM1 promoter haplotype confers protection against cerebral malaria |
Human | VEGFA | 7422 | vascular endothelial growth factor A | findings show that IP-10, sTNF-R2 and sFas were independently associated with increased risk of cerebral malaria associated mortality Postmortem brain tissue analysis demonstrates activation of the proangiogenic VEGF signaling cascade in patients with cerebral malaria |
Human | TNF | 7124 | tumor necrosis factor | frequency of the TNF U04 allele designated -1031C, -863C, and -857C was found to be significantly greater in patients with cerebral malaria than in patients with mild malaria Title:Severe malarial anemia and cerebral malaria are associated with different tumor necrosis factor promoter alleles.|Association:Y|Conclusion:Not Found |
Human | PECAM1 | 5175 | platelet/endothelial cell adhesion molecule 1 | Title:|Association:Y|Conclusion:Not Found |
Human | NOS2 | 4843 | nitric oxide synthase 2, inducible | NOS2 promoter -1173 C-->T single nucleotide polymorphism is associated with protection against cerebral malaria and severe malarial anaemia |
Human | MMP1 | 4312 | matrix metallopeptidase 1 (interstitial collagenase) | Postmortem brain tissue analysis demonstrates accumulation of MMP-1 in macrophages/microglial cells in Durck's granulomas of patients with cerebral malaria |
Human | IL12B | 3593 | interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) | The IL12B promoter polymorphism was associated with susceptibility to cerebral malaria |
Human | IL1RN | 3557 | interleukin 1 receptor antagonist | IL1B -31C>T and IL1RA VNTR polymorphisms do not play a crucial role in susceptibility or resistance to cerebral malaria |
Human | IL1B | 3553 | interleukin 1, beta | This study reports that IL1B -31C>T and IL1RA VNTR polymorphisms do not play a crucial role in susceptibility or resistance to cerebral malaria |
Human | IFNGR1 | 3459 | interferon gamma receptor 1 | IFNGR1 gene promoter polymorphisms may be assocaited with susceptibility to cerebral malaria |
Human | IFNAR1 | 3454 | interferon (alpha, beta and omega) receptor 1 | An association has been demonstrated between two IFNAR1 polymorphisms and cerebral malaria |
Human | HMOX1 | 3162 | heme oxygenase (decycling) 1 | short (GT)n alleles represent a genetic risk factor for cerebral malaria |
Human | HBE1 | 3046 | hemoglobin, epsilon 1 | the HbA/HbE polymorphism would not be a major genetic factor influencing the onset of cerebral malaria in Thailand |
Human | GYPB | 2994 | glycophorin B (MNS blood group) | GYPA & GYPB genotypes carrying MNSs antigens were analyzed in Thai patients with cerebral malaria & mild malaria; no statistical difference was found; it is concluded that MNSs antigens do not reveal the difference in susceptibility to cerebral malaria |
Human | GYPA | 2993 | glycophorin A (MNS blood group) | GYPA & GYPB genotypes carrying MNSs antigens were analyzed in Thai patients with cerebral malaria & mild malaria; no statistical difference was found; it is concluded that MNSs antigens do not reveal the difference in susceptibility to cerebral malaria |
Human | FLT1 | 2321 | fms-related tyrosine kinase 1 | Postmortem brain tissue analysis demonstrates VEGFR1 localized as paracellular deposits in Durck's granulomas of patients with cerebral malaria |
Human | CTGF | 1490 | connective tissue growth factor | Postmortem brain tissue analysis demonstrates CTGF localized occasionally in astrocytes but not in macrophages/microglial cells of patients with cerebral malaria |
Human | CR1 | 1378 | complement component (3b/4b) receptor 1 (Knops blood group) | A CR1 promoter allele, associated with higher E-CR1 expression, that conferred protection against cerebral malaria, is described |
Human | CD36 | 948 | CD36 molecule (thrombospondin receptor) | Title:CD36 polymorphism is associated with protection from cerebral malaria.|Association:Y|Conclusion:Since exon 5 of the gene is known to encode the ligand-binding domain for P. falciparum-infected erythrocytes, in3(TG)(12) itself or a primary variant on the haplotype with in3(TG)(12) may be responsible for protection from cerebral malaria in Thailand. Results of the present study suggest that LD mapping has potential for detecting a disease-associated variant on the basis of haplotype blocks. |