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Details
Link-It Detail - Disease - Malaria, Cerebral
Debug Stats
  • ### Total Build Time: 37 ms 48.194 KB
  • CONCEPT_NAME gt=2 ms Completed: 2 ms rowSize= 332 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=1 ms Completed: 1 ms rowSize= 643 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 188 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=2 ms Completed: 2 ms rowSize= 1.408 KB
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=7 ms Completed: 7 ms rowSize= 8.006 KB
  • CONCEPT_RELATIONSHIPS gt=14 ms Completed: 14 ms rowSize= 12.980 KB
  • CONCEPT_GENES gt=10 ms Completed: 10 ms rowSize= 23.478 KB
  • CONCEPT_XREFS gt=1 ms Completed: 1 ms rowSize= 1.151 KB
  • CONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Malaria, Cerebral C0024534
Definition (1)
A condition characterized by somnolence or coma in the presence of an acute infection with PLASMODIUM FALCIPARUM (and rarely other Plasmodium species). Initial clinical manifestations include HEADACHES; SEIZURES; and alterations of mentation followed by a rapid progression to COMA. Pathologic features include cerebral capillaries filled with parasitized erythrocytes and multiple small foci of cortical and subcortical necrosis. (From Adams et al., Principles of Neurology, 6th ed, p136)
Semantic Types (1)
Disease or Syndrome (T047)
Parents (3)
img Central Nervous System Protozoal Infections C0752182
img Malaria C0024530
img Malaria, Falciparum C0024535
Ancestral Roots
RootRoot Plus OneDepthParent
img Parasitic Diseases C0030499img Central Nervous System Parasitic Infections C07521814img Central Nervous System Protozoal Infections C0752182
img Nervous System Diseases C0027765img Central Nervous System Diseases C00076826img Central Nervous System Protozoal Infections C0752182
img Bacterial Infections and Mycoses C0004615img Central Nervous System Infections C00076845img Central Nervous System Protozoal Infections C0752182
img Parasitic Diseases C0030499img Protozoan Infections C00337404img Central Nervous System Protozoal Infections C0752182
img Parasitic Diseases C0030499img Protozoan Infections C00337404img Malaria C0024530
img Parasitic Diseases C0030499img Protozoan Infections C00337405img Malaria, Falciparum C0024535
Relationships (63)

Relation Types:
diso_​to_​anat : 14
diso_​to_​chem : 21
diso_​to_​diso : 17
diso_​to_​gene : 1
diso_​to_​phen : 3
diso_​to_​phys : 7


Relationships:
none : 58
clinically_​similar : 2
location_​of : 1
may_​treat : 2
Page Size
Current 25
  Page 1 of 3
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_DISO79img Complication Aspects C1171258
DISO_to_DISO64img Malaria, Falciparum C0024535
DISO_to_PHEN43img genetic aspects C0017399
DISO_to_ANAT42img Brain C0006104
DISO_to_ANAT41img In Blood C0005768
DISO_to_DISO40img Complication Aspects C1171258
DISO_to_DISO32img Falciparum Malaria C0024535
DISO_to_PHEN32img genetic aspects C0017399
DISO_to_CHEM29img 565 ANTIMALARIAL AGENTS C0003374
DISO_to_ANAT21img Brain C0006104
DISO_to_ANAT20img Erythrocytes C0014792
DISO_to_DISO20img Retinal Diseases C0035309
DISO_to_ANAT19img In Blood C0005768
DISO_to_CHEM16img 565 ANTIMALARIAL AGENTS C0003374
DISO_to_PHYS13img GENET PREDISPOSITION C0314657
DISO_to_DISO11img Coma C0009421
DISO_to_DISO11img Parasitemia C0242723
DISO_to_CHEM10img Artemisinins C1136174
DISO_to_DISO10img Cognition Disorders C0009241
DISO_to_ANAT9img CD8-Positive T-Lymphocytes C0242629
DISO_to_CHEM9img Erythropoietin C0014822
DISO_to_CHEM9img Tumor Necrosis Factor-alpha C1456820
DISO_to_DISO9img Anemia C0002871
DISO_to_ANAT8img Cell, Endothelial C0225336
DISO_to_DISO8img Malaria C0024530
Genes (20)

Species:
human : 20
SpeciesGeneGeneIdGene NameEvidence
HumanCOL18A180781collagen, type XVIII, alpha 1
img GENERIF, Score=1000, Pubmed Id: 12458056, UMLKSK CUI: C0024534
HumanHAVCR126762hepatitis A virus cellular receptor 1
img GENERIF, Score=1000, Pubmed Id: 18294362, UMLKSK CUI: C0024534
HumanVEGFA7422vascular endothelial growth factor A
img GENERIF, Score=1000, Pubmed Id: 18489763, UMLKSK CUI: C0024534
img GENERIF, Score=1000, Pubmed Id: 14512169, UMLKSK CUI: C0024534
HumanTNF7124tumor necrosis factor
img GENERIF, Score=1000, Pubmed Id: 17493155, UMLKSK CUI: C0024534
img GAD, Score=1000, Pubmed Id: 9841857, UMLKSK CUI: C0024534
HumanPECAM15175platelet/endothelial cell adhesion molecule 1
img GAD, Score=1000, Pubmed Id: 11719109, UMLKSK CUI: C0024534
HumanNOS24843nitric oxide synthase 2, inducible
img GENERIF, Score=1000, Pubmed Id: 12433515, UMLKSK CUI: C0024534
HumanMMP14312matrix metallopeptidase 1 (interstitial collagenase)
img GENERIF, Score=1000, Pubmed Id: 14512169, UMLKSK CUI: C0024534
HumanIL12B3593interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
img GENERIF, Score=1000, Pubmed Id: 18413324, UMLKSK CUI: C0024534
HumanIL1RN3557interleukin 1 receptor antagonist
img GENERIF, Score=1000, Pubmed Id: 16098232, UMLKSK CUI: C0024534
HumanIL1B3553interleukin 1, beta
img GENERIF, Score=1000, Pubmed Id: 16098232, UMLKSK CUI: C0024534
HumanIFNGR13459interferon gamma receptor 1
img GENERIF, Score=1000, Pubmed Id: 12023780, UMLKSK CUI: C0024534
HumanIFNAR13454interferon (alpha, beta and omega) receptor 1
img GENERIF, Score=1000, Pubmed Id: 12761564, UMLKSK CUI: C0024534
HumanHMOX13162heme oxygenase (decycling) 1
img GENERIF, Score=1000, Pubmed Id: 16249618, UMLKSK CUI: C0024534
HumanHBE13046hemoglobin, epsilon 1
img GENERIF, Score=1000, Pubmed Id: 18787944, UMLKSK CUI: C0024534
HumanGYPB2994glycophorin B (MNS blood group)
img GENERIF, Score=1000, Pubmed Id: 17372674, UMLKSK CUI: C0024534
HumanGYPA2993glycophorin A (MNS blood group)
img GENERIF, Score=1000, Pubmed Id: 17372674, UMLKSK CUI: C0024534
HumanFLT12321fms-related tyrosine kinase 1
img GENERIF, Score=1000, Pubmed Id: 14512169, UMLKSK CUI: C0024534
HumanCTGF1490connective tissue growth factor
img GENERIF, Score=1000, Pubmed Id: 14512169, UMLKSK CUI: C0024534
HumanCR11378complement component (3b/4b) receptor 1 (Knops blood group)
img GENERIF, Score=1000, Pubmed Id: 18954261, UMLKSK CUI: C0024534
HumanCD36948CD36 molecule (thrombospondin receptor)
img GAD, Score=1000, Pubmed Id: 12506336, UMLKSK CUI: C0024534
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0024534Malaria, Cerebral0self