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Details
Link-It Detail - Disease - Lymphohistiocytosis, Hemophagocytic
Debug Stats
  • ### Total Build Time: 143 ms 33.330 KB
  • CONCEPT_NAME gt=6 ms Completed: 6 ms rowSize= 401 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 517 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=1 ms Completed: 1 ms rowSize= 188 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=10 ms Completed: 10 ms rowSize= 570 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=8 ms Completed: 8 ms rowSize= 1.527 KB
  • CONCEPT_RELATIONSHIPS gt=96 ms Completed: 96 ms rowSize= 13.592 KB
  • CONCEPT_GENES gt=19 ms Completed: 19 ms rowSize= 15.370 KB
  • CONCEPT_XREFS gt=3 ms Completed: 3 ms rowSize= 1.169 KB
  • CONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes
  • Reload Stats
Disease (2)
Lymphohistiocytosis, Hemophagocytic C0024291
HLH
Definition (1)
A rare disorder in which histiocytes and lymphocytes (types of white blood cells) build up in organs including the skin, spleen, and liver, and destroy other blood cells. Hemophagocytic lymphohistiocytosis may be inherited or caused by certain conditions or diseases, including infections, immunodeficiency (inability of the body to fight infections), and cancer.
Semantic Types (1)
Disease or Syndrome (T047)
Parents (1)
img Histiocytosis, Non-Langerhans-Cell C0019624
Ancestral Roots
RootRoot Plus OneDepthParent
img Hemic and Lymphatic Diseases C0018981img Lymphatic Diseases C00242285img Histiocytosis, Non-Langerhans-Cell C0019624
Relationships (53)

Relation Types:
diso_​to_​anat : 5
diso_​to_​chem : 10
diso_​to_​diso : 33
diso_​to_​phen : 2
diso_​to_​phys : 3


Relationships:
none : 40
is_​finding_​of_​disease : 1
is_​normal_​cell_​origin_​of_​disease : 1
isa : 2
mapped_​to : 6
may_​be_​associated_​disease_​of_​disease : 1
may_​be_​finding_​of_​disease : 2
Page Size
Current 25
  Page 1 of 3
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_DISO195img Complication Aspects C1171258
DISO_to_PHEN128img genetic aspects C0017399
DISO_to_DISO66img EBV INFECT C0149678
DISO_to_ANAT60img In Blood C0005768
DISO_to_DISO36img Complication Aspects C1171258
DISO_to_DISO31img Lupus Erythematosus, Systemic C0024141
DISO_to_PHYS27img Mutation C0026882
DISO_to_PHEN25img genetic aspects C0017399
DISO_to_DISO23img chemically induced C0007994
DISO_to_ANAT20img Killer Cells, Natural C0022688
DISO_to_CHEM19img Membrane Associated Proteins C0025252
DISO_to_CHEM18img Immunosuppressive Agents C0021081
DISO_to_CHEM17img Pore Forming Cytotoxic Proteins C1720905
DISO_to_ANAT16img In Blood C0005768
DISO_to_CHEM16img Antibodies, Monoclonal C0003250
DISO_to_CHEM16img Ferritin C0015879
DISO_to_CHEM16img Ferritins C0015879
DISO_to_CHEM16img Perforin C0070410
DISO_to_DISO16img Lymphoma, T-Cell C0079772
DISO_to_PHYS15img Macrophage Activation C0024426
DISO_to_DISO14img Bone Marrow Failure C0030312
DISO_to_DISO14img Cytomegalovirus Infections C0010823
DISO_to_DISO14img HIV Infections C0019693
DISO_to_DISO14img Leishmaniasis, Visceral C0023290
DISO_to_ANAT13img Bone Marrow C0005953
Genes (11)

Species:
human : 11
SpeciesGeneGeneIdGene NameEvidence
HumanUNC13D201294unc-13 homolog D (C. elegans)
img GENERIF, Score=1000, Pubmed Id: 18311812, UMLKSK CUI: C0024291
img GENERIF, Score=734, Pubmed Id: 16825436, UMLKSK CUI: C0024291
HumanATF522809activating transcription factor 5
img GENERIF, Score=1000, Pubmed Id: 18832568, UMLKSK CUI: C0024291
HumanGNLY10578granulysin
img GENERIF, Score=1000, Pubmed Id: 18192122, UMLKSK CUI: C0024291
HumanTNFSF128742tumor necrosis factor (ligand) superfamily, member 12
img GENERIF, Score=1000, Pubmed Id: 17918252, UMLKSK CUI: C0024291
HumanAP3B18546adaptor-related protein complex 3, beta 1 subunit
img GENERIF, Score=840, Pubmed Id: 16551969, UMLKSK CUI: C0024291
HumanTNF7124tumor necrosis factor
img GENERIF, Score=901, Pubmed Id: 17166738, UMLKSK CUI: C0024291
HumanRAB27A5873RAB27A, member RAS oncogene family
img OMIM, Score=1000, UMLKSK CUI: C0024291
img OMIM, Score=1000, UMLKSK CUI: C0024291
HumanPRF15551perforin 1 (pore forming protein)
img GENERIF, Score=1000, Pubmed Id: 16374518, UMLKSK CUI: C0024291
img GENERIF, Score=734, Pubmed Id: 14757862, UMLKSK CUI: C0024291
img GENERIF, Score=1000, Pubmed Id: 11565555, UMLKSK CUI: C0024291
img GENERIF, Score=1000, Pubmed Id: 18190960, UMLKSK CUI: C0024291
HumanIL163603interleukin 16
img GENERIF, Score=1000, Pubmed Id: 15342983, UMLKSK CUI: C0024291
HumanIL1A3552interleukin 1, alpha
img GENERIF, Score=1000, Pubmed Id: 18024394, UMLKSK CUI: C0024291
HumanHMOX13162heme oxygenase (decycling) 1
img GENERIF, Score=901, Pubmed Id: 15899048, UMLKSK CUI: C0024291
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0024291Lymphohistiocytosis, Hemophagocytic0self