Logo arc image image
GATACA
  • Pin/Unpin Search
  • Pin/Unpin Details
Status:
Global Actions
Concepts: 0 (0)   Selected: 0 (0
Clear All Selections
 
Search
Text Search Results
Text Search Query:
none
Text Search Options:
none

Guided Help

Text Search Results
GraphTree Minimize or Maximize this Category
 Disease: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
GraphTree Minimize or Maximize this Category
 Anatomy: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
Minimize or Maximize this Category
 Gene: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
GraphTree Minimize or Maximize this Category
 Jax Mouse Phenotype: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
GraphTree Minimize or Maximize this Category
 Human Phenotype: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
GraphTree Minimize or Maximize this Category
 Gene Ontology: Biological Processes: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
GraphTree Minimize or Maximize this Category
 Gene Ontology: Cellular Component: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
GraphTree Minimize or Maximize this Category
 Gene Ontology: Molecular Function: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
Minimize or Maximize this Category
 Pathway: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
GraphTree Minimize or Maximize this Category
 Drug: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
Minimize or Maximize this Category
 Genomic Expression Atlas --
      Microarray Datasets: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
Minimize or Maximize this Category
 PubMed: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
GraphTree Minimize or Maximize this Category
 CoExpression Atlas: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
Minimize or Maximize this Category
 CoExpression: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
Minimize or Maximize this Category
 Interactions: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
Details
Link-It Detail - Disease - Liver Cirrhosis
Debug Stats
  • ### Total Build Time: 466 ms 54.318 KB
  • CONCEPT_NAME gt=8 ms Completed: 8 ms rowSize= 328 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 1.422 KB
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=1 ms Completed: 1 ms rowSize= 232 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=13 ms Completed: 13 ms rowSize= 550 bytes
  • CONCEPT_CHILDREN gt=9 ms Completed: 9 ms rowSize= 1.420 KB
  • CONCEPT_ANCESTRAL_ROOTS gt=1 ms Completed: 1 ms rowSize= 1.501 KB
  • CONCEPT_RELATIONSHIPS gt=368 ms Completed: 368 ms rowSize= 15.274 KB
  • CONCEPT_GENES gt=63 ms Completed: 63 ms rowSize= 32.440 KB
  • CONCEPT_XREFS gt=3 ms Completed: 3 ms rowSize= 1.149 KB
  • CONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Liver Cirrhosis C0023890
Definition (1)

Cirrhosis is scarring of the liver. Scar tissue forms because of injury or long-term disease. Scar tissue cannot do what healthy liver tissue does - make protein, help fight infections, clean the blood, help digest food and store energy. Cirrhosis can lead to

  • Easy bruising or bleeding, or nosebleeds
  • Swelling of the abdomen or legs
  • Extra sensitivity to medicines
  • High blood pressure in the vein entering the liver
  • Enlarged veins in the esophagus and stomach
  • Kidney failure

About 5 percent of people with cirrhosis get liver cancer.

Cirrhosis has many causes. In the United States, the most common causes are chronic alcoholism and hepatitis. Nothing will make the scar tissue disappear, but treating the cause can keep it from getting worse. If too much scar tissue forms, you may need to consider a liver transplant.

NIH: National Institute of Diabetes and Digestive and Kidney Diseases

Semantic Types (2)
Disease or Syndrome (T047)
Finding (T033)
Parents (1)
img Liver Diseases C0023895
Children (3)
img Liver Cirrhosis, Biliary C0023892
img Liver Cirrhosis, Alcoholic C0023891
img Liver Cirrhosis, Experimental C0023893
Ancestral Roots
RootRoot Plus OneDepthParent
img Digestive System Diseases C0012242img Liver Diseases C00238953img Liver Diseases C0023895
Relationships (313)

Relation Types:
diso_​to_​anat : 30
diso_​to_​chem : 105
diso_​to_​diso : 151
diso_​to_​gene : 1
diso_​to_​phen : 2
diso_​to_​phys : 24


Relationships:
none : 243
associated_​with : 1
clinically_​similar : 1
disease_​excludes_​finding : 1
disease_​has_​associated_​disease : 1
is_​associated_​anatomic_​site_​of : 3
isa : 29
mapped_​to : 3
may_​treat : 26
related_​to : 4
use : 1
Page Size
Current 25
  Page 1 of 13
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_DISO2038img Complication Aspects C1171258
DISO_to_DISO1425img Complication Aspects C1171258
DISO_to_ANAT768img Liver C0023884
DISO_to_ANAT760img In Blood C0005768
DISO_to_DISO727img Liver Neoplasms C0023903
DISO_to_DISO724img Chronic Hepatitis C C0524910
DISO_to_DISO697img Carcinoma, Hepatocellular C2239176
DISO_to_DISO538img Liver Neoplasms C0023903
DISO_to_ANAT523img In Blood C0005768
DISO_to_DISO514img Carcinoma, Hepatocellular C2239176
DISO_to_DISO458img Chronic Hepatitis C C0524910
DISO_to_ANAT384img Liver C0023884
DISO_to_PHEN367img genetic aspects C0017399
DISO_to_DISO357img Chronic Hepatitis B C0524909
DISO_to_DISO357img Hepatitis C C0019196
DISO_to_DISO343img chemically induced C0007994
DISO_to_DISO327img Fatty Liver C0015695
DISO_to_DISO313img HYPERTENSION PORTAL C0020541
DISO_to_DISO253img Hepatitis C C0019196
DISO_to_DISO239img ESOPHAGEAL GASTRIC VARICES C0014849
DISO_to_CHEM220img Antiviral Agents C0003451
DISO_to_DISO209img HYPERTENSION PORTAL C0020541
DISO_to_PHEN208img genetic aspects C0017399
DISO_to_DISO202img chemically induced C0007994
DISO_to_DISO191img Chronic Hepatitis B C0524909
Genes (142)

Species:
human : 142
Page Size
Current 25
  Page 1 of 6
Prior Page
Current 1
SpeciesGeneGeneIdGene NameEvidence
HumanZGLP1100125288zinc finger, GATA-like protein 1
img GENERIF, Score=1000, Pubmed Id: 18770489, UMLKSK CUI: C0023890
HumanHSD3B780270hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
img OMIM, Score=1000, UMLKSK CUI: C0023890
HumanRETN56729resistin
img GENERIF, Score=1000, Pubmed Id: 16478779, UMLKSK CUI: C0023890
HumanAPOM55937apolipoprotein M
img GENERIF, Score=694, Pubmed Id: 18652652, UMLKSK CUI: C0023890
HumanUGT1A754577UDP glucuronosyltransferase 1 family, polypeptide A7
img GENERIF, Score=1000, Pubmed Id: 18054330, UMLKSK CUI: C0023890
img GENERIF, Score=1000, Pubmed Id: 18021430, UMLKSK CUI: C0023890
HumanTLR954106toll-like receptor 9
img GAD, Score=1000, Pubmed Id: 15878652, UMLKSK CUI: C0023890
HumanGHRL51738ghrelin/obestatin prepropeptide
img GENERIF, Score=1000, Pubmed Id: 17344504, UMLKSK CUI: C0023890
HumanGMNN51053geminin, DNA replication inhibitor
img GENERIF, Score=1000, Pubmed Id: 16629645, UMLKSK CUI: C0023890
HumanSLC40A130061solute carrier family 40 (iron-regulated transporter), member 1
img GENERIF, Score=1000, Pubmed Id: 14768003, UMLKSK CUI: C0023890
HumanBSCL226580Berardinelli-Seip congenital lipodystrophy 2 (seipin)
img OMIM, Score=1000, UMLKSK CUI: C0023890
HumanTINF226277TERF1 (TRF1)-interacting nuclear factor 2
img OMIM, Score=1000, UMLKSK CUI: C0023890
HumanRASSF111186Ras association (RalGDS/AF-6) domain family member 1
img GENERIF, Score=1000, Pubmed Id: 18691570, UMLKSK CUI: C0023890
HumanADAMTS1311093ADAM metallopeptidase with thrombospondin type 1 motif, 13
img GENERIF, Score=901, Pubmed Id: 18521503, UMLKSK CUI: C0023890
img GENERIF, Score=827, Pubmed Id: 15710227, UMLKSK CUI: C0023890
HumanAGPAT2105551-acylglycerol-3-phosphate O-acyltransferase 2
img OMIM, Score=1000, UMLKSK CUI: C0023890
HumanPROCR10544protein C receptor, endothelial
img GENERIF, Score=1000, Pubmed Id: 17049585, UMLKSK CUI: C0023890
HumanPIAS310401protein inhibitor of activated STAT, 3
INFERRED, Score=800, UMLKSK CUI: C0023890
HumanADIPOQ9370adiponectin, C1Q and collagen domain containing
img GENERIF, Score=1000, Pubmed Id: 15010338, UMLKSK CUI: C0023890
HumanFIBP9158fibroblast growth factor (acidic) intracellular binding protein
img GENERIF, Score=1000, Pubmed Id: 17497037, UMLKSK CUI: C0023890
HumanAPLN8862apelin
img GENERIF, Score=1000, Pubmed Id: 18816630, UMLKSK CUI: C0023890
HumanNR1I28856nuclear receptor subfamily 1, group I, member 2
img GAD, Score=1000, Pubmed Id: 15690482, UMLKSK CUI: C0023890
HumanABCB118647ATP-binding cassette, sub-family B (MDR/TAP), member 11
img OMIM, Score=1000, UMLKSK CUI: C0023890
HumanWT17490Wilms tumor 1
img GENERIF, Score=1000, Pubmed Id: 12829997, UMLKSK CUI: C0023890
HumanWEE17465WEE1 homolog (S. pombe)
img GENERIF, Score=1000, Pubmed Id: 12601350, UMLKSK CUI: C0023890
HumanVIPR17433vasoactive intestinal peptide receptor 1
img GENERIF, Score=1000, Pubmed Id: 12094871, UMLKSK CUI: C0023890
HumanVEGFA7422vascular endothelial growth factor A
img GENERIF, Score=1000, Pubmed Id: 14669345, UMLKSK CUI: C0023890
img GENERIF, Score=694, Pubmed Id: 14607712, UMLKSK CUI: C0023890
img GENERIF, Score=1000, Pubmed Id: 15742396, UMLKSK CUI: C0023890
img GENERIF, Score=1000, Pubmed Id: 18656381, UMLKSK CUI: C0023890
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0023890Liver Cirrhosis0self