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Details
Link-It Detail - Disease - Leydig Cell Tumor
Debug Stats
  • ### Total Build Time: 303 ms 50.948 KB
  • CONCEPT_NAME gt=8 ms Completed: 8 ms rowSize= 332 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 697 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=1 ms Completed: 1 ms rowSize= 187 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=15 ms Completed: 15 ms rowSize= 561 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=119 ms Completed: 119 ms rowSize= 11.812 KB
  • CONCEPT_RELATIONSHIPS gt=129 ms Completed: 129 ms rowSize= 13.993 KB
  • CONCEPT_GENES gt=25 ms Completed: 25 ms rowSize= 22.221 KB
  • CONCEPT_XREFS gt=5 ms Completed: 5 ms rowSize= 1.151 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Leydig Cell Tumor C0023601
Definition (1)
A sex cord-stromal tumor occurring in the testis and rarely in the ovary. It is predominantly or completely composed of Leydig cells which may contain crystals of Reinke. In males it usually presents as a painless testicular enlargement and it may be associated with gynecomastia and decreased libido. The majority of the cases have a benign clinical course. Approximately 10% of the cases have a malignant clinical course and metastasize. In females it may be associated with androgenic manifestations and it follows a benign clinical course.
Semantic Types (1)
Neoplastic Process (T191)
Parents (1)
img Sertoli-Leydig Cell Tumor C0206723
Ancestral Roots
RootRoot Plus OneDepthParent
img Neoplasms C0027651img Neoplasms by Histologic Type C00276526img Sertoli-Leydig Cell Tumor C0206723
img Male Urogenital Diseases C1720894img Genital Diseases, Male C00174126img Sertoli-Leydig Cell Tumor C0206723
img Endocrine System Diseases C0014130img Gonadal Disorders C00180506img Sertoli-Leydig Cell Tumor C0206723
img Neoplasms C0027651img Neoplasms by Site C00276536img Sertoli-Leydig Cell Tumor C0206723
img Endocrine System Diseases C0014130img Endocrine Gland Neoplasms C00141325img Sertoli-Leydig Cell Tumor C0206723
img Male Urogenital Diseases C1720894img Urogenital Neoplasms C00420656img Sertoli-Leydig Cell Tumor C0206723
img Neoplasms C0027651img Neoplasms by Site C00276537img Sertoli-Leydig Cell Tumor C0206723
img Female Urogenital Diseases and Pregnancy Complications C1720765img Female Urogenital Diseases C17208877img Sertoli-Leydig Cell Tumor C0206723
img Female Urogenital Diseases and Pregnancy Complications C1720765img Female Urogenital Diseases C17208878img Sertoli-Leydig Cell Tumor C0206723
Relationships (38)

Relation Types:
diso_​to_​anat : 16
diso_​to_​chem : 3
diso_​to_​diso : 17
diso_​to_​phen : 2


Relationships:
none : 20
is_​abnormal_​cell_​of_​disease : 3
is_​associated_​anatomic_​site_​of : 2
is_​normal_​cell_​origin_​of_​disease : 2
is_​normal_​tissue_​origin_​of_​disease : 1
is_​not_​abnormal_​cell_​of_​disease : 3
is_​primary_​anatomic_​site_​of_​disease : 1
isa : 4
permuted_​term_​of : 1
used_​for : 1
Page Size
Current 25
  Page 1 of 2
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_DISO73img Testicular Neoplasms C0039590
DISO_to_DISO69img Testicular Neoplasms C0039590
DISO_to_DISO22img Ovarian Neoplasms C0919267
DISO_to_DISO20img Complication Aspects C1171258
DISO_to_DISO14img Ovarian Neoplasms C0919267
DISO_to_PHEN13img genetic aspects C0017399
DISO_to_DISO10img Virilism C0042755
DISO_to_PHEN10img genetic aspects C0017399
DISO_to_ANAT9img In Blood C0005768
DISO_to_ANAT8img In Blood C0005768
DISO_to_CHEM8img Receptors, LH C0034823
DISO_to_DISO8img Sertoli Cell Tumor C0036769
DISO_to_CHEM7img Phosphoprotein C0031689
DISO_to_CHEM7img Phosphoproteins C0031689
DISO_to_DISO7img Puberty, Precocious C0034013
DISO_to_ANAT6img Leydig Cells C0023602
DISO_to_ANAT6img Testis C0039597
DISO_to_DISO6img Adrenal Hyperplasia, Congenital C0001627
DISO_to_DISO6img CANINE DIS C0012979
DISO_to_DISO6img Sertoli Cell Tumor C0036769
DISO_to_ANATis_normal_cell_origin_of_diseaseimg Cells C0007634
DISO_to_ANATis_normal_tissue_origin_of_diseaseimg Endocrine Reproductive Tissue C1516843
DISO_to_ANATis_normal_cell_origin_of_diseaseimg Endocrine-Stromal Cell C1516839
DISO_to_ANATis_primary_anatomic_site_of_diseaseimg Gonadal structure C0018067
DISO_to_ANATis_associated_anatomic_site_ofimg Gonads C0018067
Genes (15)

Species:
human : 14
mouse : 1
SpeciesGeneGeneIdGene NameEvidence
MouseSRY6736sex determining region Y
img NCI, Score=801, Pubmed Id: 7516683, UMLKSK CUI: C0023601
HumanPROK184432prokineticin 1
img GENERIF, Score=756, Pubmed Id: 15292351, UMLKSK CUI: C0023601
HumanTSKS60385testis-specific serine kinase substrate
img NCI, Score=801, Pubmed Id: 11444856, UMLKSK CUI: C0023601
HumanSYP6855synaptophysin
img NCI, Score=801, Pubmed Id: 9720507, UMLKSK CUI: C0023601
HumanOSM5008oncostatin M
img NCI, Score=801, Pubmed Id: 10022451, UMLKSK CUI: C0023601
HumanMAGEA14100melanoma antigen family A, 1 (directs expression of antigen MZ2-E)
img NCI, Score=801, Pubmed Id: 10530563, UMLKSK CUI: C0023601
img NCI, Score=801, Pubmed Id: 10530563, UMLKSK CUI: C0023601
HumanLHCGR3973luteinizing hormone/choriogonadotropin receptor
img NCI, Score=801, Pubmed Id: 12447668, UMLKSK CUI: C0023601
img NCI, Score=801, Pubmed Id: 12150333, UMLKSK CUI: C0023601
img NCI, Score=801, Pubmed Id: 12408104, UMLKSK CUI: C0023601
HumanIGFBP43487insulin-like growth factor binding protein 4
img NCI, Score=801, Pubmed Id: 12646054, UMLKSK CUI: C0023601
HumanGATA42626GATA binding protein 4
img NCI, Score=801, Pubmed Id: 11061558, UMLKSK CUI: C0023601
HumanMLANA2315melan-A
img NCI, Score=801, Pubmed Id: 9422316, UMLKSK CUI: C0023601
img NCI, Score=801, Pubmed Id: 15943795, UMLKSK CUI: C0023601
img NCI, Score=801, Pubmed Id: 15943795, UMLKSK CUI: C0023601
HumanFH2271fumarate hydratase
img GENERIF, Score=966, Pubmed Id: 16757530, UMLKSK CUI: C0023601
HumanCYP21A21589cytochrome P450, family 21, subfamily A, polypeptide 2
img NCI, Score=801, Pubmed Id: 1751389, UMLKSK CUI: C0023601
img NCI, Score=801, Pubmed Id: 1751389, UMLKSK CUI: C0023601
HumanSCARB1949scavenger receptor class B, member 1
img NCI, Score=801, Pubmed Id: 9253328, UMLKSK CUI: C0023601
HumanAMHR2269anti-Mullerian hormone receptor, type II
img GENERIF, Score=966, Pubmed Id: 18310289, UMLKSK CUI: C0023601
HumanAMH268anti-Mullerian hormone
img NCI, Score=801, Pubmed Id: 14585814, UMLKSK CUI: C0023601
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0023601Leydig Cell Tumor0self