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Genes (15)
Species: human : 14 mouse : 1 | |
Mouse | SRY | 6736 | sex determining region Y | However, Leydig cells and a Leydig cell tumor were negative for Sry expression. | Human | PROK1 | 84432 | prokineticin 1 | Human EG-VEGF may play a role in angiogenesis both during the early endocrine development of testis and in the adult testis as well as in Leydig cell tumor growth | Human | TSKS | 60385 | testis-specific serine kinase substrate | TSKS expression was very low or undetectable in seminoma, teratocarcinoma, embryonal, and Leydig cell tumors, while high expression was observed in testicular tissue adjacent to tumors which contain premalignant carcinoma in situ. | Human | SYP | 6855 | synaptophysin | Synaptophysin was expressed in the non-neoplastic Sertoli and Leydig cells, 45% of the Sertoll cell tumors, and 70% of the Leydig cell tumors, in approximately similar proportions between the benign and malignant Leydig cell tumors. | Human | OSM | 5008 | oncostatin M | The immunohistochemical reaction to oncostatin M (OSM) was studied in normal human testes at different ages (fetuses, newborns, children, pubertal boys, adults, and elderly men), as well as in several testicular disorders including carcinoma-in-situ cells (CIS), germ cell tumors, benign functioning Leydig cell tumor, androgen insensitivity syndrome, Klinefelter;s syndrome, and cryptorchidism. | Human | MAGEA1 | 4100 | melanoma antigen family A, 1 (directs expression of antigen MZ2-E) | Forty-three germ cell tumors (24 seminomas, six embryonal carcinomas and 13 mixed germ cell tumors), and 10 Leydig cell tumors were selected for study, and standard immunohistochemical techniques were used on formalin-fixed paraffin-embedded tissues using mouse monoclonal antibodies to MAGE-1 (clone M454) and MAGE-3 (clone 57B) antigens. Leydig cell tumors were negative for MAGE-1 and MAGE-3. | Human | LHCGR | 3973 | luteinizing hormone/choriogonadotropin receptor | It has been recently shown that male LH-independent sexual precocity is caused by a somatic activating mutation in the luteinising hormone receptor (LHR) of Leydig cell tumours. We searched for activating mutations in exon 11 of the LHR gene and in exons 8 and 9 of the Gs-a gene, which contain all hot spots for those mutations, in 4 Leydig cell tumors obtained from 4 patients (one boy with LH-independent precocious puberty and 3 women with virilization). Germline LHR mutations that produce constitutive activation of the Gs pathway are found in cases of Leydig cell hyperplasia, while a unique somatic LHR mutation capable of activating both the Gs and Gq signaling pathways has been identified in Leydig cell tumors. | Human | IGFBP4 | 3487 | insulin-like growth factor binding protein 4 | Leydig cell tumors and mixed tumors had a significantly higher expression of IGFBP4 and IGF-IR than normal testes. | Human | GATA4 | 2626 | GATA binding protein 4 | GATA-4 protein is abundantly present in Sertoli and Leydig cell tumors, suggesting a relationship to tumorigenesis or tumor progression in somatic cell-derived testicular neoplasms. | Human | MLANA | 2315 | melan-A | However, here we report the presence of immunoreactivity for A103, an antibody to Melan-A, in five adrenocortical adenomas, 16 primary and 13 metastatic adrenocortical carcinomas, four Leydig cell tumors of the testis, and three Sertoli-Leydig cell tumors of the ovary. The distributions of melan-A, CD10, and mitochondria were characteristically patchy; in contrast, they were diffusely distributed in the cytoplasm in a control case of Leydig cell tumor. The differences in immunostaining patterns for melan-A, CD10, and mitochondria as well as positivity for S-100 protein-beta might be useful diagnostic hallmarks of large cell calcifying Sertoli cell tumor for discrimination from Leydig cell tumor. | Human | FH | 2271 | fumarate hydratase | study shows that some Leydig cell tumors are caused by fumarate hydratase mutations and represents one of the first reports of germline mutations in any type of adult testicular tumor | Human | CYP21A2 | 1589 | cytochrome P450, family 21, subfamily A, polypeptide 2 | It is suggested that the high local levels of estrogen and/or progesterone within the Leydig cell tumors and their adjacent testicular tissues induced extraadrenal expression of steroid 21-hydroxylase and 11 beta-hydroxylase by the tumors and their adjacent testicular tissues. It is suggested that the high local levels of estrogen and/or progesterone within the Leydig cell tumors and their adjacent testicular tissues induced extraadrenal expression of steroid 21-hydroxylase and 11 beta-hydroxylase by the tumors and their adjacent testicular tissues. | Human | SCARB1 | 949 | scavenger receptor class B, member 1 | CLA-1 mRNA was also highly expressed in a Leydig cell tumor, but much less in liver, kidney, and pheochromocytomas. | Human | AMHR2 | 269 | anti-Mullerian hormone receptor, type II | Reduced AMH receptor type 2 is associated with Leydig cell tumours in multiple endocrine neoplasia type 1 | Human | AMH | 268 | anti-Mullerian hormone | One such hormone, Mullerian inhibiting substance (MIS), has been shown to inhibit DNA synthesis and steroidogenesis in primary Leydig cells and Leydig cell tumor lines. |
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