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Details
Link-It Detail - Disease - Leukemia, Plasma Cell
Debug Stats
  • ### Total Build Time: 152 ms 62.275 KB
  • CONCEPT_NAME gt=10 ms Completed: 10 ms rowSize= 340 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 655 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=1 ms Completed: 1 ms rowSize= 187 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=14 ms Completed: 14 ms rowSize= 978 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=15 ms Completed: 15 ms rowSize= 7.864 KB
  • CONCEPT_RELATIONSHIPS gt=51 ms Completed: 51 ms rowSize= 15.214 KB
  • CONCEPT_GENES gt=58 ms Completed: 58 ms rowSize= 35.897 KB
  • CONCEPT_XREFS gt=2 ms Completed: 2 ms rowSize= 1.155 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Leukemia, Plasma Cell C0023484
Definition (1)
An aggressive plasma cell neoplasm with usually short survival. It is characterized by the presence of neoplastic plasma cells in the peripheral blood. The peripheral blood plasma cells comprise more than 20% of the peripheral blood white cells. It may be the initial presentation of a plasma cell neoplasm or manifest as a terminal complication of plasma cell myeloma. Lymphadenopathy and organomegaly are frequent clinical signs, whereas bone pain and osteolytic lesions are less frequently present.
Semantic Types (1)
Neoplastic Process (T191)
Parents (2)
img Leukemia C0023418
img Multiple Myeloma C0026764
Ancestral Roots
RootRoot Plus OneDepthParent
img Neoplasms C0027651img Neoplasms by Histologic Type C00276524img Leukemia C0023418
img Immune System Diseases C0021053img Immunoproliferative Disorders C00210705img Multiple Myeloma C0026764
img Hemic and Lymphatic Diseases C0018981img Hematologic Diseases C00189396img Multiple Myeloma C0026764
img Hemic and Lymphatic Diseases C0018981img Lymphatic Diseases C00242285img Multiple Myeloma C0026764
img Neoplasms C0027651img Neoplasms by Histologic Type C00276525img Multiple Myeloma C0026764
img Cardiovascular Diseases C0007222img Vascular Diseases C00423735img Multiple Myeloma C0026764
Relationships (43)

Relation Types:
diso_​to_​anat : 25
diso_​to_​chem : 5
diso_​to_​diso : 11
diso_​to_​phen : 2


Relationships:
none : 13
associated_​with : 2
classifies : 1
is_​abnormal_​cell_​of_​disease : 9
is_​associated_​anatomic_​site_​of : 1
is_​associated_​disease_​of : 1
is_​normal_​cell_​origin_​of_​disease : 6
is_​normal_​tissue_​origin_​of_​disease : 2
is_​not_​abnormal_​cell_​of_​disease : 1
is_​not_​finding_​of_​disease : 1
is_​not_​normal_​cell_​origin_​of_​disease : 2
is_​primary_​anatomic_​site_​of_​disease : 2
may_​be_​finding_​of_​disease : 1
permuted_​term_​of : 1
Page Size
Current 25
  Page 1 of 2
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_PHEN27img genetic aspects C0017399
DISO_to_DISO21img Multiple Myeloma C0026764
DISO_to_DISO18img Multiple Myeloma C0026764
DISO_to_PHEN15img genetic aspects C0017399
DISO_to_DISO11img Complication Aspects C1171258
DISO_to_ANAT10img In Blood C0005768
DISO_to_CHEM10img Antineoplastic Agents C0003392
DISO_to_CHEM9img (+)-Thalidomide C0039736
DISO_to_CHEM9img Acids, Boronic C0006032
DISO_to_CHEM9img Pyrazines C0034240
DISO_to_DISO9img Complication Aspects C1171258
DISO_to_ANAT7img In Blood C0005768
DISO_to_CHEM7img (+)-Thalidomide C0039736
DISO_to_ANATis_abnormal_cell_of_diseaseimg Atypical lymphocyte C0221277
DISO_to_ANATis_not_normal_cell_origin_of_diseaseimg B lymphoblast C1516097
DISO_to_ANATis_normal_cell_origin_of_diseaseimg B-Lymphocytes C0004561
DISO_to_ANATis_primary_anatomic_site_of_diseaseimg Bone Marrow C0005953
DISO_to_ANATis_normal_cell_origin_of_diseaseimg Bone Marrow-Homing Plasma Cell C1511241
DISO_to_ANATis_normal_tissue_origin_of_diseaseimg HEMOLYMPHORETICULAR TISSUE C1512398
DISO_to_ANATis_associated_anatomic_site_ofimg Hematopoietic and Lymphatic System C1512394
DISO_to_ANATis_normal_cell_origin_of_diseaseimg Hematopoietic and Lymphoid Cell C1512385
DISO_to_ANATis_abnormal_cell_of_diseaseimg Leukemic Cell C1517806
DISO_to_ANATis_abnormal_cell_of_diseaseimg Leukemic Lymphocyte C1517808
DISO_to_ANATis_abnormal_cell_of_diseaseimg Leukemic Plasma Cell C1517811
DISO_to_ANATis_primary_anatomic_site_of_diseaseimg Lymphatic System C0024235
Genes (20)

Species:
human : 20
SpeciesGeneGeneIdGene NameEvidence
HumanMUC1694025mucin 16, cell surface associated
img GENERIF, Score=923, Pubmed Id: 18854288, UMLKSK CUI: C0023484
HumanMAFB9935v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
img NCI, Score=801, Pubmed Id: 15543617, UMLKSK CUI: C0023484
HumanBCL108915B-cell CLL/lymphoma 10
img NCI, Score=801, Pubmed Id: 11241793, UMLKSK CUI: C0023484
img NCI, Score=801, Pubmed Id: 11241793, UMLKSK CUI: C0023484
img NCI, Score=801, Pubmed Id: 11241793, UMLKSK CUI: C0023484
img NCI, Score=801, Pubmed Id: 11241793, UMLKSK CUI: C0023484
HumanTYRO37301TYRO3 protein tyrosine kinase
img NCI, Score=801, Pubmed Id: 11468178, UMLKSK CUI: C0023484
HumanTIMP37078TIMP metallopeptidase inhibitor 3
img NCI, Score=801, Pubmed Id: 15197802, UMLKSK CUI: C0023484
HumanSPIB6689Spi-B transcription factor (Spi-1/PU.1 related)
img NCI, Score=801, Pubmed Id: 11841448, UMLKSK CUI: C0023484
HumanSPI16688spleen focus forming virus (SFFV) proviral integration oncogene
img NCI, Score=801, Pubmed Id: 11841448, UMLKSK CUI: C0023484
HumanSDC16382syndecan 1
img NCI, Score=801, Pubmed Id: 11877089, UMLKSK CUI: C0023484
img NCI, Score=801, Pubmed Id: 15512818, UMLKSK CUI: C0023484
HumanPOU2F25452POU class 2 homeobox 2
img NCI, Score=801, Pubmed Id: 11841448, UMLKSK CUI: C0023484
img NCI, Score=801, Pubmed Id: 11841448, UMLKSK CUI: C0023484
HumanPAX55079paired box 5
img NCI, Score=801, Pubmed Id: 11841448, UMLKSK CUI: C0023484
HumanNCAM14684neural cell adhesion molecule 1
img GENERIF, Score=717, Pubmed Id: 18231917, UMLKSK CUI: C0023484
HumanMAF4094v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
img NCI, Score=801, Pubmed Id: 15543617, UMLKSK CUI: C0023484
HumanIL33562interleukin 3 (colony-stimulating factor, multiple)
img NCI, Score=801, Pubmed Id: 8518172, UMLKSK CUI: C0023484
img NCI, Score=801, Pubmed Id: 2064960, UMLKSK CUI: C0023484
img NCI, Score=801, Pubmed Id: 8518172, UMLKSK CUI: C0023484
HumanFRZB2487frizzled-related protein
img NCI, Score=801, Pubmed Id: 11468178, UMLKSK CUI: C0023484
img NCI, Score=801, Pubmed Id: 11468178, UMLKSK CUI: C0023484
HumanDAPK11612death-associated protein kinase 1
img NCI, Score=801, Pubmed Id: 15197802, UMLKSK CUI: C0023484
HumanCDKN2C1031cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
img NCI, Score=801, Pubmed Id: 9012694, UMLKSK CUI: C0023484
img NCI, Score=801, Pubmed Id: 9012694, UMLKSK CUI: C0023484
HumanCDKN2B1030cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
img NCI, Score=801, Pubmed Id: 9012694, UMLKSK CUI: C0023484
img NCI, Score=801, Pubmed Id: 15197802, UMLKSK CUI: C0023484
img NCI, Score=801, Pubmed Id: 9012694, UMLKSK CUI: C0023484
HumanCCND3896cyclin D3
img NCI, Score=801, Pubmed Id: 15543617, UMLKSK CUI: C0023484
HumanBRAF673v-raf murine sarcoma viral oncogene homolog B
img NCI, Score=801, Pubmed Id: 14616967, UMLKSK CUI: C0023484
img NCI, Score=801, Pubmed Id: 12931219, UMLKSK CUI: C0023484
img GENERIF, Score=1000, Pubmed Id: 12931219, UMLKSK CUI: C0023484
HumanPRDM1639PR domain containing 1, with ZNF domain
img NCI, Score=801, Pubmed Id: 11841448, UMLKSK CUI: C0023484
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0023484Leukemia, Plasma Cell0self