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Details
Link-It Detail - Disease - Leukemia, Megakaryoblastic, Acute
Debug Stats
  • ### Total Build Time: 240 ms 59.329 KB
  • CONCEPT_NAME gt=7 ms Completed: 7 ms rowSize= 424 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 289 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=91 ms Completed: 91 ms rowSize= 187 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=4 ms Completed: 4 ms rowSize= 560 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 1.509 KB
  • CONCEPT_RELATIONSHIPS gt=92 ms Completed: 92 ms rowSize= 16.454 KB
  • CONCEPT_GENES gt=43 ms Completed: 43 ms rowSize= 38.738 KB
  • CONCEPT_XREFS gt=2 ms Completed: 2 ms rowSize= 1.167 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Reload Stats
Disease (2)
Leukemia, Megakaryoblastic, Acute C0023462
Acute Megakaryocytic Leukemias
Definition (1)
An acute myeloid leukemia in which at least 50% of the blasts are of megakaryocytic lineage. The prognosis is usually poor. (WHO, 2001)
Semantic Types (1)
Neoplastic Process (T191)
Parents (1)
img Leukemia, Myeloid, Acute C0023467
Ancestral Roots
RootRoot Plus OneDepthParent
img Neoplasms C0027651img Neoplasms by Histologic Type C00276526img Leukemia, Myeloid, Acute C0023467
Relationships (51)

Relation Types:
diso_​to_​anat : 19
diso_​to_​chem : 5
diso_​to_​diso : 21
diso_​to_​phen : 4
diso_​to_​phys : 2


Relationships:
none : 16
associated_​with : 1
classifies : 1
is_​abnormal_​cell_​of_​disease : 6
is_​associated_​anatomic_​site_​of : 1
is_​finding_​of_​disease : 1
is_​normal_​cell_​origin_​of_​disease : 3
is_​normal_​tissue_​origin_​of_​disease : 2
is_​not_​abnormal_​cell_​of_​disease : 2
is_​not_​finding_​of_​disease : 3
is_​not_​normal_​cell_​origin_​of_​disease : 1
is_​primary_​anatomic_​site_​of_​disease : 1
isa : 3
may_​be_​abnormal_​cell_​of_​disease : 3
may_​be_​associated_​disease_​of_​disease : 1
may_​be_​finding_​of_​disease : 4
sort_​version_​of : 1
used_​for : 1
Page Size
Current 25
  Page 1 of 3
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_PHEN67img genetic aspects C0017399
DISO_to_PHEN66img genetic aspects C0017399
DISO_to_DISO38img Down Syndrome C0013080
DISO_to_DISO32img Complication Aspects C1171258
DISO_to_DISO22img Complication Aspects C1171258
DISO_to_CHEM20img Binding Protein, DNA C0012940
DISO_to_CHEM19img GATA1 Transcription Factor C0118889
DISO_to_CHEM17img TRANSCRIPTION FACTOR C0040648
DISO_to_DISO14img Myeloproliferative Disorders C0027022
DISO_to_PHYS14img Mutation C0026882
DISO_to_PHYS12img Mutation C0026882
DISO_to_ANAT11img In Blood C0005768
DISO_to_CHEM9img Chimeric Oncogene Proteins C0029014
DISO_to_DISO9img Myeloproliferative Disorders C0027022
DISO_to_CHEM8img GATA1 Transcription Factor C0118889
DISO_to_DISO8img Chromosomal translocation C0040715
DISO_to_ANATis_not_abnormal_cell_of_diseaseimg Atypical Lymphoblast C0333826
DISO_to_ANATmay_be_abnormal_cell_of_diseaseimg Atypically Small Megakaryocyte C0333861
DISO_to_ANATis_associated_anatomic_site_ofimg Bone Marrow C0005953
DISO_to_ANATis_normal_cell_origin_of_diseaseimg Bone Marrow Stem Cell C1511246
DISO_to_ANATis_normal_cell_origin_of_diseaseimg Bone Marrow Stem Cell Committed to the Megakaryocytic Lineage C1706984
DISO_to_ANATis_abnormal_cell_of_diseaseimg Cancer Cell C0334227
DISO_to_ANATmay_be_abnormal_cell_of_diseaseimg Dysplastic Neutrophil C1512107
DISO_to_ANATis_normal_tissue_origin_of_diseaseimg HEMOLYMPHORETICULAR TISSUE C1512398
DISO_to_ANATis_normal_tissue_origin_of_diseaseimg Haematopoietic tissue C0229619
Genes (24)

Species:
human : 24
SpeciesGeneGeneIdGene NameEvidence
HumanPPBPL1728045
img NCI, Score=801, Pubmed Id: 7488550, UMLKSK CUI: C0023462
HumanRBM1564783RNA binding motif protein 15
img NCI, Score=801, Pubmed Id: 11344311, UMLKSK CUI: C0023462
img NCI, Score=801, Pubmed Id: 11431691, UMLKSK CUI: C0023462
img GENERIF, Score=1000, Pubmed Id: 18667423, UMLKSK CUI: C0023462
HumanMKL157591megakaryoblastic leukemia (translocation) 1
img NCI, Score=801, Pubmed Id: 12019265, UMLKSK CUI: C0023462
img NCI, Score=801, Pubmed Id: 11431691, UMLKSK CUI: C0023462
HumanST7L54879suppression of tumorigenicity 7 like
img NCI, Score=801, Pubmed Id: 12012006, UMLKSK CUI: C0023462
HumanA4GALT53947alpha 1,4-galactosyltransferase
img GENERIF, Score=734, Pubmed Id: 11782470, UMLKSK CUI: C0023462
HumanGNLY10578granulysin
img GENERIF, Score=673, Pubmed Id: 12145461, UMLKSK CUI: C0023462
HumanRBM610180RNA binding motif protein 6
img GENERIF, Score=1000, Pubmed Id: 17360941, UMLKSK CUI: C0023462
HumanFXR29513fragile X mental retardation, autosomal homolog 2
img NCI, Score=801, Pubmed Id: 16778363, UMLKSK CUI: C0023462
img NCI, Score=801, Pubmed Id: 16778363, UMLKSK CUI: C0023462
HumanPICALM8301phosphatidylinositol binding clathrin assembly protein
img GENERIF, Score=1000, Pubmed Id: 17170719, UMLKSK CUI: C0023462
HumanMLLT108028myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
img NCI, Score=801, Pubmed Id: 7564531, UMLKSK CUI: C0023462
HumanPDGFB5155platelet-derived growth factor beta polypeptide
img NCI, Score=801, Pubmed Id: 2955817, UMLKSK CUI: C0023462
img NCI, Score=801, Pubmed Id: 2955817, UMLKSK CUI: C0023462
img NCI, Score=801, Pubmed Id: 2955817, UMLKSK CUI: C0023462
HumanTNFRSF11B4982tumor necrosis factor receptor superfamily, member 11b
img GENERIF, Score=1000, Pubmed Id: 15307108, UMLKSK CUI: C0023462
HumanMTR45485-methyltetrahydrofolate-homocysteine methyltransferase
img OMIM, Score=1000, UMLKSK CUI: C0023462
HumanJAK33718Janus kinase 3
img GENERIF, Score=1000, Pubmed Id: 17456055, UMLKSK CUI: C0023462
HumanITGB33690integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
img NCI, Score=801, Pubmed Id: 10550559, UMLKSK CUI: C0023462
img NCI, Score=801, Pubmed Id: 3297208, UMLKSK CUI: C0023462
HumanITGA2B3674integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
img NCI, Score=801, Pubmed Id: 10483140, UMLKSK CUI: C0023462
img NCI, Score=801, Pubmed Id: 7536511, UMLKSK CUI: C0023462
HumanMNX13110motor neuron and pancreas homeobox 1
img GENERIF, Score=1000, Pubmed Id: 18940475, UMLKSK CUI: C0023462
HumanGATA12623GATA binding protein 1 (globin transcription factor 1)
img GENERIF, Score=694, Pubmed Id: 14656875, UMLKSK CUI: C0023462
img GENERIF, Score=1000, Pubmed Id: 12172547, UMLKSK CUI: C0023462
img GENERIF, Score=1000, Pubmed Id: 17576817, UMLKSK CUI: C0023462
img GENERIF, Score=901, Pubmed Id: 14744791, UMLKSK CUI: C0023462
img OMIM, Score=1000, UMLKSK CUI: C0023462
img GENERIF, Score=1000, Pubmed Id: 12816863, UMLKSK CUI: C0023462
img GENERIF, Score=1000, Pubmed Id: 16249385, UMLKSK CUI: C0023462
img GENERIF, Score=884, Pubmed Id: 14636651, UMLKSK CUI: C0023462
HumanFGF12246fibroblast growth factor 1 (acidic)
img NCI, Score=801, Pubmed Id: 7488550, UMLKSK CUI: C0023462
HumanERG2078v-ets avian erythroblastosis virus E26 oncogene homolog
img GENERIF, Score=966, Pubmed Id: 16140924, UMLKSK CUI: C0023462
HumanCSF1R1436colony stimulating factor 1 receptor
img GENERIF, Score=845, Pubmed Id: 17360941, UMLKSK CUI: C0023462
HumanCDA978cytidine deaminase
img NCI, Score=801, Pubmed Id: 15687366, UMLKSK CUI: C0023462
HumanCBS875cystathionine-beta-synthase
img GENERIF, Score=840, Pubmed Id: 12393509, UMLKSK CUI: C0023462
HumanBMP6654bone morphogenetic protein 6
img NCI, Score=801, Pubmed Id: 8026832, UMLKSK CUI: C0023462
img NCI, Score=801, Pubmed Id: 7488550, UMLKSK CUI: C0023462
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0023462Leukemia, Megakaryoblastic, Acute0self