|Mouse||ESX1||80712||ESX homeobox 1|
Here we have investigated whether increased cell proliferation and aberrant expression of two genes that are involved in placental growth control, Igf2 and Esx1, may cause, or contribute to placental hyperplasia.
Furthermore, in early developmental stages of placental hyperplasia, we observed a decreased expression of the X-chromosomal Esx1 gene.
|Mouse||STRA6||64220||stimulated by retinoic acid 6|
Up-regulation of Stra6 mRNA was also observed in hyperplastic mammary tissue and mammary gland tumors from transgenic mice expressing Wnt-1 and in human tumors that frequently harbor defects in Wnt-1 signaling.
|Mouse||ICOS||29851||inducible T-cell co-stimulator|
In contrast, in OVA-sensitized mice intratracheal injection of CD80/CD86-/- OVA-pulsed DCs led to eosinophilic airway inflammation, goblet cell hyperplasia, and effector TH2 cytokine production that was not different from that seen after injection with WT OVA-DCs, even when the inducible costimulator ICOS was blocked or cytotoxic T lymphocyte-associated antigen 4 immunoglobulin was given.
|Mouse||LYPD3||27076||LY6/PLAUR domain containing 3|
Phorbol-ester-induced hyperplasia of mouse skin is also accompanied by a significant induction of C4.4A expression in the multilayered, suprabasal keratinocytes.
|Mouse||TNFRSF13B||23495||tumor necrosis factor receptor superfamily, member 13B|
TACI;s role is controversial based on defects in TI antibody responses accompanied by B cell hyperplasia in knockout mice.
|Mouse||CHEK2||11200||checkpoint kinase 2|
Uterus hyperplasia and increased carcinogen-induced tumorigenesis in mice carrying a targeted mutation of the Chk2 phosphorylation site in Brca1.
|Mouse||CDC37||11140||cell division cycle 37|
Although targeted overexpression in mice leads to prostate epithelial cell hyperplasia, the effect of Cdc37 dysregulation in human prostate cells is unclear.
|Mouse||NEU3||10825||sialidase 3 (membrane sialidase)|
Here we demonstrate that mice overexpressing the human ortholog (NEU3) develop diabetic phenotype by 18-22 weeks associated with hyperinsulinemia, islet hyperplasia, and increased beta-cell mass.
|Mouse||TNFSF13B||10673||tumor necrosis factor (ligand) superfamily, member 13b|
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|Mouse||TXNIP||10628||thioredoxin interacting protein|
In addition, severe lymphoid hyperplasia in the small intestine was observed in VDUP1-/- mice.
|Mouse||SPRY2||10253||sprouty homolog 2 (Drosophila)|
We report here that loss of the Sprouty2 gene (also known as Spry2) in mice resulted in enteric nerve hyperplasia, which led to esophageal achalasia and intestinal pseudo-obstruction.
Loss of mammalian Sprouty2 leads to enteric neuronal hyperplasia and esophageal achalasia.
Here we show that inhibition of cell death by enforced expression of netrin-1 in mouse gastrointestinal tract leads to the spontaneous formation of hyperplastic and neoplastic lesions.
|Mouse||PTTG1||9232||pituitary tumor-transforming 1|
Here we show that mice lacking PTTG (PTTG -/-) are, surprisingly, viable and fertile; but they have testicular and splenic hypoplasia, thymic hyperplasia, and thrombocytopenia.
Pituitary PTTG expression results in plurihormonal hyperplasia and hormone-secreting microadenomas with profound peripheral growth-stimulatory effects on the prostate and urinary tract.
|Mouse||IQGAP1||8826||IQ motif containing GTPase activating protein 1|
Loss of IQGAP1 also does not affect tumor development or tumor progression, but mutant mice exhibit a significant (P _lt_ 0.0001) increase in late-onset gastric hyperplasia relative to wild-type animals of the same genetic background.
|Mouse||BHLHE40||8553||basic helix-loop-helix family, member e40|
In vivo, Stra13 deficiency results in ineffective elimination of activated T and B cells, which accumulate progressively, leading to lymphoid organ hyperplasia.
|Mouse||PLA2G6||8398||phospholipase A2, group VI (cytosolic, calcium-independent)|
The group II PLA2 transgenic mice reported here exhibit epidermal and adnexal hyperplasia, hyperkeratosis, and almost total alopecia.
Expression of human group II PLA2 in transgenic mice results in epidermal hyperplasia in the absence of inflammatory infiltrate.
|Mouse||MADCAM1||8174||mucosal vascular addressin cell adhesion molecule 1|
In vitro and in vivo functional assays show that the addressin/homing receptor pairs PNAd/L-selectin and MAdCAM-1/alpha 4 beta 7 are involved in lymphocyte traffic to the hyperplastic thymus.
|Mouse||NCOA4||8031||nuclear receptor coactivator 4|
We have previously reported that the thyroid-targeted expression of the RET/PTC3 oncogene (Tg-RET/PTC3) in transgenic mice induces follicular hyperplasia with papillary architecture, resulting in a modest increase of the thyroid gland volume, followed by the appearance of papillary carcinomas in approximately 1-year-old animals.
|Mouse||CXCR4||7852||chemokine (C-X-C motif) receptor 4|
Inhibition of plaque area and SMC content in apolipoprotein E-deficient mice repopulated with LacZ+ or CXCR4-/- BM or lentiviral transfer of an antagonist reveals a crucial involvement of local SDF-1alpha and its receptor CXCR4 in neointimal hyperplasia via recruitment of BM-derived SMC progenitors.
|Mouse||ZFP36||7538||ZFP36 ring finger protein|
Mice made deficient in TTP by gene targeting appeared normal at birth, but soon manifested marked medullary and extramedullary myeloid hyperplasia associated with cachexia, erosive arthritis, dermatitis, conjunctivitis, glomerular mesangial thickening, and high titers of anti-DNA and antinuclear antibodies.
Tristetraprolin-deficient [TTP (-/-)] mice exhibit a complex syndrome of myeloid hyperplasia, cachexia, dermatitis, autoimmunity, and erosive arthritis.
|Mouse||ZAP70||7535||zeta-chain (TCR) associated protein kinase 70kDa|
Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice.
|Mouse||XRCC5||7520||X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)|
Here we show that ku86-mutant mice, compared with control littermates, prematurely exhibited age-specific changes characteristic of senescence that include osteopenia, atrophic skin, hepatocellular degeneration, hepatocellular inclusions, hepatic hyperplastic foci, and age-specific mortality.
|Mouse||XPC||7508||xeroderma pigmentosum, complementation group C|
Exposure to 80 J/m2 UV radiation (i.e., suberythemogenic in CSB -/-) on 10 consecutive days gives rise to epidermal hyperplasia in CSB -/- and XPC -/-, whereas repair-proficient controls do not show epidermal hyperplasia from these exposures.
|Mouse||WNT10B||7480||wingless-type MMTV integration site family, member 10B|
Transgenic expression of Wnt1 or Wnt10b in the mouse mammary gland leads to lobuloalveolar hyperplasia with a major risk of progression to carcinoma.
|Mouse||WNT5A||7474||wingless-type MMTV integration site family, member 5A|
Furthermore, noggin mutants and Bmpr1a conditional mutant mice displayed hypoplasia and hyperplasia of the external genitalia respectively. noggin mutant mice exhibited downregulation of Wnt5a and Fgf8 expression with decreased cell proliferation.