Genes (35)
Species: human : 35 | |
Human | ERVK7 | 449619 | | HERV-K expression was also found in malignant GTD (choriocarcinoma) but not in benign GTD (noninvasive molar pregnancy). | Human | NLRP7 | 199713 | NLR family, pyrin domain containing 7 | Our findings firmly establish that NLRP7 mutations are a major cause of biparental hydatidiform moles and confirm presence of a complex pattern of imprinting abnormalities in BiHM tissues Five mutations in the maternal gene NALP7 in individuals with familial and recurrent Hydatidiform mole Mutation my be involed in the inflammatory and apoptoic pathways in hydatidiform moles study reports a first stop codon, c.295G>T (p.Glu99X) and a missense mutation, c.1970A>T (p.Asp657Val) in NLRP7 in two sisters with familial recurrent hydatidiform moles Role of NALP7 in apoptosis and inflammation pinpoints previously unrecognized pathways that could directly or indirectly underlie the abnormal methylation of imprinted genes in hydatidiform moles tissues | Human | PSCA | 8000 | prostate stem cell antigen | Overexpression of prostate stem cell antigen (PSCA) is associated with development of gestational trophoblastic neoplasia in hydatidiform mole | Human | TJP1 | 7082 | tight junction protein 1 | Expression of ZO-1 and occludin in normal human placenta and in hydatidiform moles. In the present report we have investigated the expression of ZO-1 and occludin in normal human placentae and in hydatidiform moles using immunohistochemical and Western blot analyses. | Human | TERC | 7012 | telomerase RNA component | To determine the regulation mechanism of telomerase activity in hydatidiform moles, we studied telomerase activity at the single cell level (using an in situ TRAP assay), and expression of TLP1 (telomerase protein 1), TERC (telomerase RNA component) and TERT (telomerase reverse transcriptase component). | Human | RFC2 | 5982 | replication factor C (activator 1) 2, 40kDa | METHODS: The expression of RFC2 and PCNA were detected with immunohistochemical method in 15 cases of normal villi, 38 cases of hydatidiform moles (HM), 42 cases of invasive moles (IM), and 18 cases of choriocarcinomas (CC). | Human | RASA1 | 5921 | RAS p21 protein activator (GTPase activating protein) 1 | To assess the role that Ras-GAP plays in the development of trophoblastic tumors, we performed immunohistochemical analyses with anti RasGAP antibodies of normal placentas, hydatidiform moles, invasive moles, and malignant choriocarcinomas. | Human | PZP | 5858 | pregnancy-zone protein | INFERRED, Score=800, UMLKSK CUI: C0020217 | Human | PTEN | 5728 | phosphatase and tensin homolog | the regulation of PTEN expression may play an important role in the development of the early gestational trophoblast and in the pathogenesis of hydatidiform mole, but not in its malignant transformation | Human | PEG3 | 5178 | paternally expressed 3 | Our data support that PEG3 is not mutated in women with familial recurrent hydatidiform moles, although mutations in the regulatory regions that might affect imprinting or transcriptional level of the gene could not be evaluated. We analyzed the PEG3 gene for mutations in women with familial recurrent hydatidiform moles and to determine its imprinting status in humans. | Human | NOS3 | 4846 | nitric oxide synthase 3 (endothelial cell) | The aim of this study was to examine the mRNA expression of the vasoconstrictor endothelin-1 (ET-1), its receptor ET-A and the endothelial constitutive nitric oxide synthase (ecNOS), forming the vasodilator nitric oxide, in hydatidiform moles. The results demonstrated the presence of mRNA expression of ET-1, ET-A and ecNOS in hydatidiform moles and that the level of mRNA expression did not vary from that in control placentas. | Human | NME1 | 4830 | NME/NM23 nucleoside diphosphate kinase 1 | The aim of the present study was to investigate the expression of nm23-H1 in human placenta, hydatidiform mole and choriocarcinoma cells. Expression of nm23-H1 in hydatidiform mole and its relationship with the development of postmolar disease. In the hydatidiform mole cases with subsequent spontaneous remission, nm23-H1 mRNA levels were significantly lower than those in first-trimester placentas. | Human | MMP2 | 4313 | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | overexpression of matrix metallopeptidase 2 and mutant p53 is associated with hydatidiform mole | Human | MEST | 4232 | mesoderm specific transcript | MEST was abundantly expressed in hydatidiform moles of androgenetic origin, whereas it was barely detectable in dermoid cysts of parthenogenetic origin. | Human | MCM7 | 4176 | minichromosome maintenance complex component 7 | AIMS: To assess the proliferative activity of gestational trophoblastic disease (GTD) using one of the novel proliferation markers (MCM7) and to determine its prognostic value in hydatidiform mole (HM). | Human | IDO1 | 3620 | indoleamine 2,3-dioxygenase 1 | Hydatidiform moles express IDO, but the majority of gestational trophoblastic tumors do not express this enzyme, suggesting that IDO-mediated immunoregulation is unlikely to be a major component of the malignant phenotype in these tumors | Human | IGFBP1 | 3484 | insulin-like growth factor binding protein 1 | The clinical applications of PP12, PP14 and PAPP-A measurements are not only limited to uterine pathologies but also include cancer (tumour markers) and pregnancy (hydatidiform moles and extra-uterine pregnancies). Serial determinations of PP12 have been made in 31 patients with trophoblastic tumours (16 hydatidiform moles, 10 invasive moles and five choriocarcinomas). | Human | ID4 | 3400 | inhibitor of DNA binding 4, dominant negative helix-loop-helix protein | Methods and results : Immunohistochemistry for Id1, Id2, Id3 and Id4 was performed on 83 trophoblastic tissues including 17 normal first-trimester placentas, seven term placentas, 47 hydatidiform moles (HM), and 12 spontaneous miscarriages. | Human | ID3 | 3399 | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein | Methods and results : Immunohistochemistry for Id1, Id2, Id3 and Id4 was performed on 83 trophoblastic tissues including 17 normal first-trimester placentas, seven term placentas, 47 hydatidiform moles (HM), and 12 spontaneous miscarriages. | Human | ID2 | 3398 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | Methods and results : Immunohistochemistry for Id1, Id2, Id3 and Id4 was performed on 83 trophoblastic tissues including 17 normal first-trimester placentas, seven term placentas, 47 hydatidiform moles (HM), and 12 spontaneous miscarriages. | Human | ID1 | 3397 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | Methods and results : Immunohistochemistry for Id1, Id2, Id3 and Id4 was performed on 83 trophoblastic tissues including 17 normal first-trimester placentas, seven term placentas, 47 hydatidiform moles (HM), and 12 spontaneous miscarriages. | Human | GPC1 | 2817 | glypican 1 | The expression of syn-1, -2, -3, -4, and glypican-1 has been studied in normal human placenta and in gestational trophoblastic disease such as hydatidiform mole, invasive mole, and choriocarcinoma, using immunohistochemistry and western blots. | Human | ERV3 | 2086 | endogenous retrovirus group 3, member 1 | It is concluded that (a) ERV3 env is expressed in syncytiotrophoblasts not only in the placenta but also in hydatidiform moles and choriocarcinomas (irrespective of origin) (b) ERV3 expression in placenta correlates to cell fusion but probably not to the fertilization process itself (c) ERV3 env is highly expressed in certain cells in spermatogenesis but not in the Sertoli or Leydig cells, and finally (d) ERV3 env is expressed in certain embryonic tissues such as the adrenal gland and nervous tissues. | Human | EPOR | 2057 | erythropoietin receptor | expression in placenta increased in abortive tissue and hydatidiform mole | Human | EPO | 2056 | erythropoietin | expression in placenta increased in abortive tissue and hydatidiform mole |
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