Mouse | TNFRSF12A | 51330 | tumor necrosis factor receptor superfamily, member 12A | Furthermore, the murine Fn14 gene is rapidly induced during liver regeneration in vivo and is expressed at high levels in the hepatocellular carcinoma nodules that develop in the c-myc/transforming growth factor-alpha-driven and the hepatitis B virus X protein-driven transgenic mouse models of hepatocarcinogenesis. |
Mouse | CD274 | 29126 | CD274 molecule | By using semi-quantitative RT-PCR method, it was found that PD-L1 mRNA but not PD-L2 mRNA was expressed in H22 hepatoma cells and both PD-L1 and PD-L2 mRNAs were expressed in tumor tissues of tumor-bearing mice and upregulated as compared with muscle tissues in normal mice and H22 hepatoma cells. |
Mouse | TXNIP | 10628 | thioredoxin interacting protein | Click here to display 4 evidence detail records. |
Mouse | HTATIP2 | 10553 | HIV-1 Tat interactive protein 2, 30kDa | Using genetically engineered mice and cells deficient in TIP30, we show that TIP30-deficient mice have a high incidence of hepatocellular carcinoma and other tumors, and loss of TIP30 enhances susceptibility of fibroblasts to transformation by the SV40 large T antigen. Furthermore, immunohistochemical analysis indicates that reduced TIP30 expression is associated with 33% of human hepatocellular carcinomas. |
Mouse | FGF19 | 9965 | fibroblast growth factor 19 | FGF19 transgenic mice had elevated hepatic alpha-fetoprotein mRNA as early as 2 months of age, and hepatocellular carcinomas were evident by 10 months of age. A mouse model of hepatocellular carcinoma: ectopic expression of fibroblast growth factor 19 in skeletal muscle of transgenic mice. |
Mouse | SOCS2 | 8835 | suppressor of cytokine signaling 2 | Socs2 induction seems B cell-specific, because no induction was observed in TCDD-responsive mouse hepatoma cells or human breast cancer cells. |
Mouse | XRCC5 | 7520 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | Interestingly, haplo-insufficiency of Ku80 in PARP-1-/- mice promotes the development of hepatocellular adenoma and hepatocellular carcinoma (HCC). Taken together, these data implicate a synergistic function of Ku80 and PARP-1 in minimized chromosome aberrations and cancer development and suggest that defects in DNA end-processing molecules may be etiological factors in human HCC formation. |
Mouse | UGT1A | 7361 | UDP glucuronosyltransferase 1 family, polypeptide A complex locus | This study demonstrates that the expression of the UGT1 gene UGT1A6, 1A7 and 1A8 is regulated at the transcriptional level by 3-methylcholanthene (3-MC) in rat hepatoma H-4-II-E cells. |
Mouse | TIMP2 | 7077 | TIMP metallopeptidase inhibitor 2 | We report a novel approach to gene therapy of hepatocellular carcinoma (HCC), using repeated injections of DNA plasmids encoding the tissue inhibitors of metalloproteinases (TIMPs) TIMP-2 or TIMP-3, and a novel competent formulation of gene transfer based on nontoxic cationic cholesterol derivatives. Gene therapy for hepatocellular carcinoma using non-viral vectors composed of bis guanidinium-tren-cholesterol and plasmids encoding the tissue inhibitors of metalloproteinases TIMP-2 and TIMP-3. |
Mouse | TEC | 7006 | transient erythroblastopenia of childhood | Using low stringency screening, we could isolate cDNAs of a putative protein-tyrosine kinase, tec (tyrosine kinase expressed in hepatocellular carcinoma). |
Mouse | TCF4 | 6925 | transcription factor 4 | The beta-catenin activation was further suggested by the fact that all hepatocellular carcinoma (HCC) cell lines examined showed the nuclear beta-catenin/TCF4 complex together with cyclin D1 over-expression. |
Mouse | STK11 | 6794 | serine/threonine kinase 11 | Here we demonstrate that the Lkb1 (+/-) mice develop hepatocellular carcinomas (HCCs). |
Mouse | STAT5B | 6777 | signal transducer and activator of transcription 5B | The signaling by endogenous LIF and OSM receptors differed from that by IL-6R by the prominent activation of STAT5 as shown in the mouse hepatoma cell line, Hepa-1. |
Mouse | SIM1 | 6492 | single-minded homolog 1 (Drosophila) | Introduction of SIM1 into hepatoma cells inhibits transcriptional transactivation by the endogenous AHR.ARNT dimer. |
Mouse | SDC2 | 6383 | syndecan 2 | Hepatoma (HepG2) cells and endothelial cells cultured in high glucose also showed decreased sulfate and glucosamine incorporation into HSPG. |
Mouse | CCL21 | 6366 | chemokine (C-C motif) ligand 21 | When we used different doses of a constructed eukaryotic expression plasmid, pSLC, which expresses functional murine secondary lymphoid tissue chemokine (SLC, CCL21), to treat BALB/c mice inoculated with H22 murine hepatoma cells, the inhibitory effect was enhanced along with the increase of pSLC dosage. |
Mouse | SAA3P | 6290 | serum amyloid A3 pseudogene | To study further roles of NF-kappa B and C/EBP transcription factor family members in SAA3 gene activation, expression vectors for NF-kappa B subunits (p50 and p65) and C/EBP family members (C/EBP-alpha and NFIL-6, also called C/EBP-beta) were co-transfected into Hep3B hepatoma and F9 embryonic carcinoma cells. |
Mouse | RPS6 | 6194 | ribosomal protein S6 | In mouse hepatoma cells (BWTG3), the Rps6 gene is hemizygously deleted but the remaining copy shows no sequence anomaly in the coding region, indicating that Rps6 is not oncosuppressor and that another gene acting as an oncosuppressor is located in its vicinity. |
Mouse | ROCK1 | 6093 | Rho-associated, coiled-coil containing protein kinase 1 | These findings confirm the importance of the Rho/p160ROCK signaling pathway in intrahepatic metastasis of human HCC, and indicate that Y-27632 may be useful for the prevention of intrahepatic metastasis of human HCC. |
Mouse | RBL2 | 5934 | retinoblastoma-like 2 (p130) | Overexpression of tumour suppressor retinoblastoma 2 protein (pRb2/p130) in hepatocellular carcinoma. |
Mouse | PTK2 | 5747 | protein tyrosine kinase 2 | We demonstrated previously that rat ascites hepatoma MM1 cells require both lysophosphatidic acid (LPA) and fibronectin (FN) for phagokinetic motility and transcellular migration and that these events are regulated through the RhoA-ROCK pathway and tyrosine phosphorylation of proteins including focal adhesion kinase (FAK). |
Mouse | PRKAR1A | 5573 | protein kinase, cAMP-dependent, regulatory, type I, alpha | Click here to display 4 evidence detail records. |
Mouse | PPARA | 5465 | peroxisome proliferator-activated receptor alpha | Evidence from mice lacking fatty acyl-CoA oxidase (AOX), PPAR alpha and PPAR alpha/AOX has confirmed the role of PPAR alpha in the development of hepatocellular carcinomas. |
Mouse | ABCB4 | 5244 | ATP-binding cassette, sub-family B (MDR/TAP), member 4 | Click here to display 8 evidence detail records. |
Mouse | PGK1 | 5230 | phosphoglycerate kinase 1 | Hypoxia induces a 10-fold accumulation of phosphoglycerate kinase 1 mRNA in wild type mouse hepatoma (Hepa 1c1c7) cells; the induction mechanism is Arnt dependent because induction does not occur in Arnt-defective cells. |