Debug Stats | ### Total Build Time: 70 ms 44.606 KB CONCEPT_NAME gt=2 ms Completed: 2 ms rowSize= 320 bytesCONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytesCONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 365 bytes- Skipping details on:
CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes - Skipping details on:
CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes CONCEPT_SEMANTIC_TYPE gt=1 ms Completed: 1 ms rowSize= 187 bytes- Skipping details on:
CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes CONCEPT_PARENTS gt=5 ms Completed: 5 ms rowSize= 557 bytesCONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytesCONCEPT_ANCESTRAL_ROOTS gt=4 ms Completed: 4 ms rowSize= 6.616 KBCONCEPT_RELATIONSHIPS gt=48 ms Completed: 48 ms rowSize= 15.062 KBCONCEPT_GENES gt=9 ms Completed: 9 ms rowSize= 20.353 KBCONCEPT_XREFS gt=1 ms Completed: 1 ms rowSize= 1.146 KBCONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes- Reload Stats
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Relationships (39)
Relation Types: diso_to_anat : 15 diso_to_diso : 24
Relationships: none : 7 is_abnormal_cell_of_disease : 4 is_associated_anatomic_site_of : 2 is_finding_of_disease : 5 is_normal_cell_origin_of_disease : 5 is_normal_tissue_origin_of_disease : 1 is_not_abnormal_cell_of_disease : 1 is_not_finding_of_disease : 3 is_primary_anatomic_site_of_disease : 2 isa : 2 may_be_associated_disease_of_disease : 2 may_be_cytogenetic_abnormality_of_disease : 1 may_be_finding_of_disease : 3 permuted_term_of : 1 | |
DISO_to_DISO | 60 | |
Pancreatic Neoplasm C0030297 | DISO_to_DISO | 52 | |
Pancreatic Neoplasm C0030297 | DISO_to_DISO | 32 | |
Complication Aspects C1171258 | DISO_to_DISO | 20 | |
Complication Aspects C1171258 | DISO_to_DISO | 17 | |
Erythema C0041834 | DISO_to_DISO | 13 | |
Erythema C0041834 | DISO_to_DISO | 8 | |
Insulinoma C0021670 | DISO_to_ANAT | | is_associated_anatomic_site_of |
Digestive System C0012240 | DISO_to_ANAT | | is_primary_anatomic_site_of_disease |
Endocrine System C0014136 | DISO_to_ANAT | | is_normal_cell_origin_of_disease |
Enteroendocrine Cell C0524979 | DISO_to_ANAT | | is_normal_cell_origin_of_disease |
Enteroendocrine Cells C0524979 | DISO_to_ANAT | | is_normal_cell_origin_of_disease |
Epithelial Cells C0014597 | DISO_to_ANAT | | is_normal_tissue_origin_of_disease |
Epithelial Tissue C0014609 | DISO_to_ANAT | | is_normal_cell_origin_of_disease |
Glucagon-Secreting Cells C0030280 | DISO_to_ANAT | | is_normal_cell_origin_of_disease |
Islet Cell C1522529 | DISO_to_ANAT | | is_primary_anatomic_site_of_disease |
Islets of Langerhans C0022131 | DISO_to_ANAT | | is_abnormal_cell_of_disease |
Neoplastic Cell C0597032 | DISO_to_ANAT | | is_abnormal_cell_of_disease |
Neoplastic Endocrine Cell C1513951 | DISO_to_ANAT | | is_abnormal_cell_of_disease |
Neoplastic Epithelial Cell C1513959 | DISO_to_ANAT | | is_abnormal_cell_of_disease |
Neoplastic Neuroendocrine Cell C1514044 | DISO_to_ANAT | | is_not_abnormal_cell_of_disease |
Neoplastic Smooth Muscle Cell C1514098 | DISO_to_ANAT | | is_associated_anatomic_site_of |
Pancreas C0030274 | DISO_to_DISO | | is_not_finding_of_disease |
Absence of a Hormonal Syndrome C1706686 | DISO_to_DISO | | isa |
Alpha cell tumor, malignant C0334282 | DISO_to_DISO | | may_be_associated_disease_of_disease |
Anemia C0002871 |
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Genes (13)
Species: human : 13 | |
Human | MAFA | 389692 | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A | In the islet glucagonoma cell line alphaTC1.6, overexpression of PDX-1 and MafA separately increased promoter activity approx. | Human | GATA5 | 140628 | GATA binding protein 5 | We show here that Gata-4 and/or Gata-6 are not only expressed in the adult exocrine pancreas but also in glucagonoma and insulinoma cell lines, whereas Gata-5 is restricted to the exocrine pancreas. | Human | SSTR5 | 6755 | somatostatin receptor 5 | In two cases of glucagonoma and its metastatic lymph nodes in one case, all the SSTR subtype mRNAs except SSTR5 mRNA were expressed. | Human | PTPRN | 5798 | protein tyrosine phosphatase, receptor type, N | An RNase protection assay demonstrated that some of these PTPs were expressed predominantly in glucagonoma (i.e., PTPdelta and IA-2) and others in insulinoma (i.e., PTP1C, PTPkappa, and PTPNE3) cells. Absorption of diabetic sera with unlabeled recombinant IA-2 or IA-2beta, prior to incubation with radiolabeled 37-kDa and 40-kDa tryptic fragments derived from insulinoma or glucagonoma cells, blocks the immunoprecipitation of both of these radiolabeled tryptic fragments. | Human | PRKCA | 5578 | protein kinase C, alpha | As immunoreactivity of PKC-alpha and -gamma was found in the tumor cells, but not in the normal A cells of the islets of Langerhans, the PKC subspecies alpha and gamma, which are not present in normal pancreatic A cells, may exist in human glucagonoma cells. | Human | PDX1 | 3651 | pancreatic and duodenal homeobox 1 | Forced expression of recombinant PDX1 in the glucagonoma resulted in efficient transcriptional activation of the endogenous insulin and IAPP genes, but did not affect glucagon gene activity. We find that in addition to insulin the insulinoma express the normal beta-cell markers Pdx-1, IAPP, and Glut-2, and that these markers are absent from the glucagonoma: a reflection of the normal alpha-cell. To investigate if this sensitivity represents an acquired trait during beta-cell maturation, we used two in vitro cultured cell systems: 1) a pluripotent glucagon-positive pre-beta-cell phenotype (NHI-glu) that, after in vivo passage, matures into an insulin-producing beta-cell phenotype (NHI-ins) and 2) a glucagonoma cell-type (AN-glu) that, after stable transfection with pancreatic duodenal homeobox factor-1 (PDX-1), acquires the ability to produce insulin (AN-ins). In the islet glucagonoma cell line alphaTC1.6, overexpression of PDX-1 and MafA separately increased promoter activity approx. | Human | IAPP | 3375 | islet amyloid polypeptide | Forced expression of recombinant PDX1 in the glucagonoma resulted in efficient transcriptional activation of the endogenous insulin and IAPP genes, but did not affect glucagon gene activity. Within the different syndromes, 1/11 individuals with insulinoma, 2/16 with gastrinoma, 0/2 with glucagonoma, 0/3 with VIPoma and 5/26 with non-functioning tumours showed elevated plasma levels of IAPP. IAPP mRNA was confined to the beta-cell phenotype when analyzing the phenotypically stable in vivo tumor lines, MSL-G2-IN (insulinoma) and MSL-G-AN (glucagonoma), and the transgenic mouse islet cell lines, beta-Tc and alpha-Tc. Induction of insulin and islet amyloid polypeptide production in pancreatic islet glucagonoma cells by insulin promoter factor 1. | Human | HES1 | 3280 | hairy and enhancer of split 1, (Drosophila) | Moreover, distinct glucagonoma lines derived by stable HES-1 transfection of the insulinoma caused severe anorexia but retained low circulating levels of CART comparable to that of insulinoma bearing or control rats. | Human | GATA6 | 2627 | GATA binding protein 6 | We show here that Gata-4 and/or Gata-6 are not only expressed in the adult exocrine pancreas but also in glucagonoma and insulinoma cell lines, whereas Gata-5 is restricted to the exocrine pancreas. | Human | GATA4 | 2626 | GATA binding protein 4 | We show here that Gata-4 and/or Gata-6 are not only expressed in the adult exocrine pancreas but also in glucagonoma and insulinoma cell lines, whereas Gata-5 is restricted to the exocrine pancreas. | Human | CHGB | 1114 | chromogranin B (secretogranin 1) | Nonneoplastic alpha cells from patients with a functioning glucagonoma showed a decreased glucagon immunoreactivity, whereas the expression of chromogranin A (but not chromogranin B and secretoneurin) was as intense as in alpha cells not associated with glucagonoma syndrome. | Human | CDK6 | 1021 | cyclin-dependent kinase 6 | Insulinomas, glucagonoma, PP-omas and non-functioning tumours were weakly stained for cdk6 and p16. | Human | BTC | 685 | betacellulin | Furthermore, strong immunoreactivity to BTC was detected in primitive duct cells of the fetal pancreas, and both insulinoma and glucagonoma cells also showed positive immunoreactivity to BTC. |
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