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Relationships (247)
Relation Types: diso_to_anat : 34 diso_to_chem : 95 diso_to_diso : 67 diso_to_gene : 26 diso_to_phen : 3 diso_to_phys : 22
Relationships: none : 166 disease_has_associated_disease : 1 eo_disease_maps_to_human_disease : 3 gene_associated_with_disease : 24 gene_product_malfunction_associated_with_disease : 3 is_abnormal_cell_of_disease : 7 is_associated_anatomic_site_of : 1 is_finding_of_disease : 6 is_normal_cell_origin_of_disease : 4 is_normal_tissue_origin_of_disease : 2 is_not_finding_of_disease : 3 is_primary_anatomic_site_of_disease : 1 isa : 8 location_of : 1 may_be_abnormal_cell_of_disease : 2 may_be_cytogenetic_abnormality_of_disease : 5 may_be_finding_of_disease : 3 may_be_molecular_abnormality_of_disease : 1 may_treat : 4 permuted_term_of : 1 used_for : 1 | |
DISO_to_DISO | 2387 | |
Brain Neoplasms C0006118 | DISO_to_DISO | 1103 | |
Brain Neoplasms C0006118 | DISO_to_PHEN | 971 | |
genetic aspects C0017399 | DISO_to_PHEN | 389 | |
genetic aspects C0017399 | DISO_to_CHEM | 276 | |
Antineoplastic Agents C0003392 | DISO_to_CHEM | 246 | |
Dacarbazine C0010927 | DISO_to_ANAT | 214 | |
Cell, Neoplastic Stem C1956421 | DISO_to_CHEM | 190 | |
ALKYLATING AGENTS ANTINEOPL C0282532 | DISO_to_DISO | 171 | |
LOCAL NEOPL RECURRENCE C0027643 | DISO_to_DISO | 170 | |
ASTROCYTOMA C0004114 | DISO_to_PHYS | 166 | |
Apoptosis C0162638 | DISO_to_ANAT | 157 | |
Blood supply aspects C0005839 | DISO_to_PHYS | 154 | |
GENE EXPRESSION REG NEOPL C0017268 | DISO_to_CHEM | 136 | |
Epidermal Growth Factor Receptor C0034802 | DISO_to_CHEM | 118 | |
BIOCHEM TUMOR MARKERS C0041366 | DISO_to_DISO | 117 | |
Complication Aspects C1171258 | DISO_to_CHEM | 115 | |
Antineoplastic Agents C0003392 | DISO_to_DISO | 107 | |
ASTROCYTOMA C0004114 | DISO_to_PHYS | 107 | |
Signal Transduction C0037083 | DISO_to_CHEM | 102 | |
Proteins, Tumor Suppressor C0597611 | DISO_to_DISO | 93 | |
Neovascularization, Pathologic C0027686 | DISO_to_CHEM | 92 | |
Dacarbazine C0010927 | DISO_to_CHEM | 88 | |
ANGIOGENESIS INHIB C0596087 | DISO_to_PHYS | 88 | |
Cell Proliferation C0596290 | DISO_to_ANAT | 84 | |
Blood supply aspects C0005839 |
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Genes (510)
Species: human : 501 mouse : 9 | |
Mouse | PAOX | 196743 | polyamine oxidase (exo-N4-amino) | An almost complete prevention of tumor growth was achieved in U-251 human glioblastoma xenografted nude mice, by partial decontamination of the gastrointestinal tract and feeding of a polyamine-free diet containing inhibitors of ornithine decarboxylase (DFMO) and of polyamine oxidase (MDL 72527). | Mouse | GOPC | 57120 | golgi-associated PDZ and coiled-coil motif containing | Here, we show that a glioblastoma-associated, ligand-independent rearrangement product of ROS (FIG-ROS) cooperates with loss of the tumor suppressor gene locus Ink4a;Arf to produce glioblastomas in the mouse. | Mouse | SMOX | 54498 | spermine oxidase | An almost complete prevention of tumor growth was achieved in U-251 human glioblastoma xenografted nude mice, by partial decontamination of the gastrointestinal tract and feeding of a polyamine-free diet containing inhibitors of ornithine decarboxylase (DFMO) and of polyamine oxidase (MDL 72527). | Mouse | HYAL2 | 8692 | hyaluronoglucosaminidase 2 | Similarly, all glioblastomas multiforme expressed hyaluronidases MGEA5 and Hyal2. | Mouse | OSM | 5008 | oncostatin M | Click here to display 3 evidence detail records. | Mouse | MLF1 | 4291 | myeloid leukemia factor 1 | Immunohistochemical analysis of rat F98 and C6 GBM tumor models showed that MLF1IP was highly expressed in the tumor core where it was co-localized with MLF1 and nestin. | Mouse | LGALS3BP | 3959 | lectin, galactoside-binding, soluble, 3 binding protein | Expression levels of the immunostimulatory 90K antigen in mammary carcinoma, glioblastoma, and other tumor-derived cell lines inversely correlate with their tumorigenicity in athymic mice. | Mouse | IL13 | 3596 | interleukin 13 | Three alternate day injections (qod) of IL-13 toxin (250 microg/kg/day) into other subcutaneous U87 glioblastoma tumors also produced durable complete responses (CR) in all 5 mice. This conclusion was made based on (a) time-dependent induction of several proapoptotic molecules, such as caspases (caspase-3, -8, and -9) in tumors; (b) cleavage of procaspase-3 and poly(ADP-ribose) polymerase (PARP); and (c) the release of cytochrome c from mitochondria to the cytosol on injection of IL-13 cytotoxin in U251 glioblastoma tumors established in immunodeficient animals. | Mouse | HIF1A | 3091 | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Evaluation of hypoxia-inducible factor-1alpha (HIF-1alpha) as an intrinsic marker of tumor hypoxia in U87 MG human glioblastoma: in vitro and xenograft studies. | Human | CD24 | 100133941 | CD24 molecule | CD24 is modulated by IGFBP-2 and contributes to IGFBP-2-enhanced invasiveness of glioblastoma cells | Human | CCR2 | 729230 | chemokine (C-C motif) receptor 2 | Overexpression of CC chemokine receptor-2A (CCR2A) was seen in glioblastoma specimens localized in the cytoplasm, and pronounced CCR2A immunoreactivity in tumor-infiltrating area was associated with prior chemo/radiation therapy | Human | SPANXA2 | 728712 | SPANX family, member A2 | Overall SPANXA was the most frequently expressed SPANX variant in melanoma and glioblastoma cell lines. | Human | MAGED4 | 728239 | melanoma antigen family D, 4 | MAGED4 was expressed in 30% of RCC and both glioblastoma samples. We analyzed the expression of 21 MAGE genes in ten RCC samples and two glioblastoma samples and could identify the first MHC class I ligand NIGDEALIGRW from MAGED4 presented by HLA-A*25 on RCC solid tumor tissue. | Human | MIR7-1 | 407043 | | microRNA-7 (miR-7) is a potential tumor suppressor in glioblastoma targeting critical cancer pathways | Human | MIR222 | 407007 | microRNA 222 | Data show that p27(Kip1) is a direct target for microRNAs 221 and 222, and suggest a role for these microRNAs in promoting the aggressive growth of glioblastoma | Human | MIR221 | 407006 | microRNA 221 | The most interesting results came from miR-221, strongly up-regulated in glioblastoma and from a set of brain-enriched miRNAs, miR-128, miR-181a, miR-181b, and miR-181c, which are down-regulated in glioblastoma. | Human | MIR21 | 406991 | microRNA 21 | Click here to display 5 evidence detail records. | Human | MIR181C | 406957 | microRNA 181c | The most interesting results came from miR-221, strongly up-regulated in glioblastoma and from a set of brain-enriched miRNAs, miR-128, miR-181a, miR-181b, and miR-181c, which are down-regulated in glioblastoma. | Human | MIR181B2 | 406956 | microRNA 181b-2 | The most interesting results came from miR-221, strongly up-regulated in glioblastoma and from a set of brain-enriched miRNAs, miR-128, miR-181a, miR-181b, and miR-181c, which are down-regulated in glioblastoma. | Human | MIR181B1 | 406955 | microRNA 181b-1 | The most interesting results came from miR-221, strongly up-regulated in glioblastoma and from a set of brain-enriched miRNAs, miR-128, miR-181a, miR-181b, and miR-181c, which are down-regulated in glioblastoma. | Human | MIR181A2 | 406954 | microRNA 181a-2 | The most interesting results came from miR-221, strongly up-regulated in glioblastoma and from a set of brain-enriched miRNAs, miR-128, miR-181a, miR-181b, and miR-181c, which are down-regulated in glioblastoma. | Human | MIR128-2 | 406916 | | The most interesting results came from miR-221, strongly up-regulated in glioblastoma and from a set of brain-enriched miRNAs, miR-128, miR-181a, miR-181b, and miR-181c, which are down-regulated in glioblastoma. | Human | MIR128-1 | 406915 | | The most interesting results came from miR-221, strongly up-regulated in glioblastoma and from a set of brain-enriched miRNAs, miR-128, miR-181a, miR-181b, and miR-181c, which are down-regulated in glioblastoma. | Human | SPRED3 | 399473 | sprouty-related, EVH1 domain containing 3 | Mutation analysis of CBL-C and SPRED3 on 19q in human glioblastoma. | Human | IL31 | 386653 | interleukin 31 | In the present work, we analyzed the signaling properties of IL-31 in glioblastoma and melanoma tumor cells. |
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