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Genes (28)
Species: human : 28 | |
Human | GHRL | 51738 | ghrelin/obestatin prepropeptide | Data show that plasma obestatin and ghrelin are lower in chronic atrophic gastritis than in healthy subjects, ghrelin to obestatin ratio is decreased, and a relationship exists between atrophy and decreased obestatin ghrelin secretion is negatively affected by autoimmune gastritis | Human | TNF | 7124 | tumor necrosis factor | Title:A proinflammatory genetic profile increases the risk for chronic atrophic gastritis and gastric carcinoma.|Association:Y|Conclusion:These findings show that a proinflammatory polymorphism in the TNF-alpha gene is associated with increased risk for GC, and that it is possible to define a specific genetic profile associated with highest risk for CAG and GC. | Human | TGFA | 7039 | transforming growth factor, alpha | mRNA expression in atrophic gastritis before and after Helicobacter pylori eradication | Human | SPINK1 | 6690 | serine peptidase inhibitor, Kazal type 1 | CONCLUSIONS: The decrease in tissue PSTI levels associated with gastric atrophy probably represents a permanent reduction in one of the mucosal defense mechanisms. | Human | SHH | 6469 | sonic hedgehog | We concluded that the decreased expression of the Shh pathway in atrophic gastritis and gastric cancer might reflect altered differentiation processes within the gastric unit and contributes to the development of gastric atrophy. Decreased expression of the Shh pathway in atrophic gastritis and gastric cancer might reflect altered differentiation processes within the gastric unit and contributes to the development of gastric atrophy | Human | PTPN11 | 5781 | protein tyrosine phosphatase, non-receptor type 11 | Single nucleotide polymorphism at intron 3 of PTPN11 gene is associated with a lower risk of gastric atrophy | Human | PIK3CA | 5290 | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | Chronic atrophic gastritis | Human | MUTYH | 4595 | mutY homolog (E. coli) | Chronic atrophic gastritis | Human | KRAS | 3845 | Kirsten rat sarcoma viral oncogene homolog | Chronic atrophic gastritis | Human | IRF1 | 3659 | interferon regulatory factor 1 | Chronic atrophic gastritis | Human | PDX1 | 3651 | pancreatic and duodenal homeobox 1 | Impaired expression of the gastric morphogenic factor Sonic Hedgehog by parietal cells and increased expression of the transcriptional activators of intestinal and pancreatic differentiation, namely CDX2 and PDX1, seem to be crucial for the development of gastric atrophy and for intestinal, endocrine and pancreatic transdifferentiation processes. | Human | IL13 | 3596 | interleukin 13 | Title:Interleukin-2 gene polymorphisms associated with increased risk of gastric atrophy from Helicobacter pylori infection.|Association:Y|Conclusion:These results reveal that the IL-2 gene polymorphism is associated with an increased risk of gastric atrophy induced by H. pylori infection and might predispose to gastric cancer. | Human | IL4R | 3566 | interleukin 4 receptor | Homozygotes with the low activity allele of the A398G polymorphism in the IL4R gene had a modest increase in risk of atrophic gastritis (OR = 1.52, 95% CI: 1.05-2.21), compared with homozygotes of the high activity allele | Human | IL2 | 3558 | interleukin 2 | Title:Interleukin-2 gene polymorphisms associated with increased risk of gastric atrophy from Helicobacter pylori infection.|Association:Y|Conclusion:These results reveal that the IL-2 gene polymorphism is associated with an increased risk of gastric atrophy induced by H. pylori infection and might predispose to gastric cancer. gene polymorphism is associated with an increased risk of gastric atrophy induced by H. pylori infection and might predispose to gastric cancer | Human | IL1RN | 3557 | interleukin 1 receptor antagonist | In atrophic ody gastritis patients IL-1RN polymorphisms does not appear to be associated either with specific clinical, biochemical or histological features or with the development of gastric neoplastic lesions at long-term follow-up Chronic atrophic gastritis | Human | IL1B | 3553 | interleukin 1, beta | In atrophic body gastritis patients IL-1B-511 polymorphism does not appear to be associated either with specific clinical, biochemical or histological features or with the development of gastric neoplastic lesions at long-term follow-up Title:A proinflammatory genetic profile increases the risk for chronic atrophic gastritis and gastric carcinoma.|Association:Y|Conclusion:These findings show that a proinflammatory polymorphism in the TNF-alpha gene is associated with increased risk for GC, and that it is possible to define a specific genetic profile associated with highest risk for CAG and GC. Chronic atrophic gastritis Interleukin 1beta polymorphisms increase risk of hypochlorhydria and atrophic gastritis and reduce risk of duodenal ulcer recurrence in Japan This study suggests that host genetic constitution (particlularly, IL1B genetic polymorphism) and lifestyle may influence the protective effect for atrophic gastritis development | Human | FGFR2 | 2263 | fibroblast growth factor receptor 2 | Chronic atrophic gastritis | Human | ERBB2 | 2064 | v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 | Chronic atrophic gastritis | Human | DAPK1 | 1612 | death-associated protein kinase 1 | No association was found between promoter methylation of DAPK and Helicobacter pylori infection, whereas a close association was observed with the presence of gastric atrophy and DAPK promoter methylation (P=0.015). Collectively, DAPK promoter methylation and down-regulation is tightly associated with gastric atrophy, which often contributes to the preneoplastic changes in gastric carcinogenesis. Promoter methylation and down-regulation of DAPK is associated with gastric atrophy. DAPK promoter methylation and down-regulation is tightly associated with gastric atrophy, often contributes to the preneoplastic changes in gastric carcinogenesis Herein we have examined whether the promoter methylation of DAPK gene or down-modulation of DAPK is associated with gastric atrophy. | Human | KLF6 | 1316 | Kruppel-like factor 6 | Chronic atrophic gastritis | Human | CDX2 | 1045 | caudal type homeobox 2 | Increased CDX2 mRNA is associated with chronic atrophic gastritis | Human | CDX1 | 1044 | caudal type homeobox 1 | Increased CDX1 mRNA expression is associated with chronic atrophic gastritis | Human | CDH1 | 999 | cadherin 1, type 1, E-cadherin (epithelial) | Chronic atrophic gastritis | Human | CASP10 | 843 | caspase 10, apoptosis-related cysteine peptidase | Chronic atrophic gastritis | Human | AREG | 374 | amphiregulin | mRNA expression in atrophic gastritis before and after Helicobacter pylori eradication |
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