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human : 11
DESIGN: To extend previous observations, we examined the lymph nodes located in the gastrinoma triangle of 20 autopsy cases for the presence of neuroendocrine cells, as determined by immunohistochemistry, using antibodies to a panneuroendocrine substance (eg, synaptophysin) and a specific neuropeptide (eg, gastrin).
In the present study, metastases of several types of NE tumors, including medullary thyroid carcinoma, gastrinoma, insulinoma, small (oat) cell carcinoma of the lung, gastrointestinal carcinoid, and neuroblastoma, were examined for the presence of synaptophysin by immunocytochemistry, with the use of tissue sections as well as centrifuged cell suspensions and by immunoblotting of tumor proteins.
Five of the 20 gastrinoma triangle cases contained synaptophysin reactive cells, whereas 3 had gastrin reactive cells.
Dominant negative action of an abnormal secretin receptor arising from mRNA missplicing in a gastrinoma.
We studied gastrinoma cells in vitro to determine whether secretin would stimulate gastrin release directly and whether the gastrinoma cell membrane had a functional secretin receptor adenylate cyclase system.
Secretin-receptor and secretin-receptor-variant expressions occur in all gastrinomas
This spliceoform has only recently been recognized in a rare gastrinoma, where it was incapable of binding secretin or signaling, and possessed dominant-negative activity to suppress hormone action at the wild-type secretin receptor (1).
The growth of the human gastrinoma model (PT) in athymic nude mice is stimulated by bombesin (BBS), an amphibian peptide homologous to both human gastrin-releasing peptide (GRP) and neuromedin B (NMB).
Effects of neuromedin B and GRP-10 on gastrin and insulin release from cultured tumor cells of a malignant gastrinoma.
|Human||MEN1||4221||multiple endocrine neoplasia I|
nonfunctional pancreatic tumor was more common in the frameshift/nonsense or 1657insC mutation carriers, whereas gastrinoma was more common in the in-frame/missense or 1466del12 mutation carriers
Study demonstrates that alterations in the MEN1 gene are involved in about half of all sporadic gastrinomas
|Human||IGF1R||3480||insulin-like growth factor 1 receptor|
IGF-IR level was lower in gastrinomas of patients who were rendered disease free and increased levels correlated with tumor growth, aggressiveness, extent, and with liver metastases
|Human||IAPP||3375||islet amyloid polypeptide|
Within the different syndromes, 1/11 individuals with insulinoma, 2/16 with gastrinoma, 0/2 with glucagonoma, 0/3 with VIPoma and 5/26 with non-functioning tumours showed elevated plasma levels of IAPP.
Immunocytochemical staining of tumour tissue showed that 9/13 (69%) of insulin producing tumours, 4/14 (29%) of non-functioning tumours and 1/9 (11%) of gastrin producing tumours were IAPP immunoreactive.
|Human||GHRH||2691||growth hormone releasing hormone|
Zollinger-Ellison syndrome. Cure by surgical resection of a jejunal gastrinoma containing growth hormone releasing factor.
Southern blotting profiles for normal gastric antrum and gastrinoma DNA were indistinguishable from each other within the 18-kb region containing the gastrin gene, showing that no genomic rearrangements are associated with the gastrinoma formation.
Our results indicate that gastrin-producing tumors in the pancreas are not ectopic, but arise from cells that normally express the gastrin gene.
A subset of tumors with immunohistochemical expression of gastrin but without evidence of Zollinger-Ellison syndrome (ZES) should be designated as functionally inactive duodenal neuroendocrine tumors (NETs) expressing gastrin, but not as gastrinomas
|Human||ERBB2||2064||v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2|
Her-2/neu expression and gene amplification in gastrinomas is correlated with tumor biology, growth, and aggressiveness
|Human||CXADR||1525||coxsackie virus and adenovirus receptor|
Reverse transcriptase-polymerase chain reaction and subsequent Southern blot hybridization revealed the presence of the CaR gene in human gastrinoma tissues.
Human gastrinoma cells express calcium-sensing receptor.
We investigated the mechanism of calcium-stimulated gastrin release from gastrinoma cells in vitro with a particular focus on the calcium-sensing receptor (CaR).