Human | SH3GLB1 | 51100 | SH3-domain GRB2-like endophilin B1 | Bif-1 expression might play a role in tumorigenesis in both urinary bladder (UB) and gallbladder (GB) cancer |
Human | KEAP1 | 9817 | kelch-like ECH-associated protein 1 | Aberrant Nrf2 activation provoked by Keap1 alteration is one of the molecular mechanisms for chemotherapeutic resistance in gallbladder cancer |
Human | CES2 | 8824 | carboxylesterase 2 | Among the 18 types of tumors analyzed, 2 types (gallbladder tumor and lymphoma) did not express CES2, 5 types expressed weak CES2, and 11 types expressed moderate to intense CES2. |
Human | VEGFC | 7424 | vascular endothelial growth factor C | Expresssed in gallbladder cancer and is related to lymph node metastasis |
Human | TP53 | 7157 | tumor protein p53 | These results suggest that the Val allele of CYP1A1 Ile462Val polymorphism and the Pro allele of TP53 Arg72Pro polymorphism contribute to an increased risk of gallbladder cancer among Japanese women and men, respectively p53 and c-erbB-2 may have independent role in carcinogenesis of gall bladder cancer |
Human | TOP2A | 7153 | topoisomerase (DNA) II alpha 170kDa | Somatostatin could induce cell cycle arrest in S phase and upregulate Topo IIalpha expression in gallbladder cancer cells |
Human | TNF | 7124 | tumor necrosis factor | TNFA-308G/A polymorphism is associated with gallbladder cancer |
Human | TGFB1 | 7040 | transforming growth factor, beta 1 | Transforming growth factor beta overexpression is associated with advanced stage gallbladder cancer the combination of the GG genotype of EGF and the CT genotype of TGFB1 demonstrated synergistic increase in risk of gallbladder cancer |
Human | OGG1 | 4968 | 8-oxoguanine DNA glycosylase | These results suggest that hOGG1 Ser326Cys polymorphism is associated with gallbladder cancer risk |
Human | NFE2L2 | 4780 | nuclear factor, erythroid 2-like 2 | Aberrant Nrf2 activation provoked by Keap1 alteration is one of the molecular mechanisms for chemotherapeutic resistance in gallbladder cancer |
Human | MTHFR | 4524 | methylenetetrahydrofolate reductase (NAD(P)H) | The genetic risk for gallbladder cancer is not modulated by MTHFR C677T polymorphism |
Human | MGMT | 4255 | O-6-methylguanine-DNA methyltransferase | Cisplatin enhanced sensitivity to ACNU gallbladder cancer cells expressing MGMT both in vitro and in vivo |
Human | TACSTD2 | 4070 | tumor-associated calcium signal transducer 2 | EpCAM expression in gallbladder tumors may serve as a prognostic factor for poor survival |
Human | IL1RN | 3557 | interleukin 1 receptor antagonist | Individuals with 1/C and 2/C haplotypes of IL-1RN VNTR and -511IL-1B C --> T polymorphisms were more susceptible to develop gallbladder cancer with gallstones compared to healthy controls in north India |
Human | GSTT1 | 2952 | glutathione S-transferase theta 1 | To find out the association of GST variants with risk of gallbladder cancer, the distribution of polymorphisms in the GST family of genes (GSTT1, GSTM1, GSTP1, and GSTM3) were studied in 106 cancer patients and 201 healthy controls |
Human | GALNT3 | 2591 | UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3) | In gallbladder cancer, the presence of diffuse-type localization of GalNAc-T3 in the subserosal layer is correlated with aggressiveness of the diseases |
Human | ESR2 | 2100 | estrogen receptor 2 (ER beta) | Loss of estrogen receptor beta expression is associated with gallbladder cancer progression |
Human | ERBB2 | 2064 | v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 | p53 and c-erbB-2 may have independent role in carcinogenesis of gall bladder cancer |
Human | EGF | 1950 | epidermal growth factor | the combination of the GG genotype of EGF and the CT genotype of TGFB1 demonstrated synergistic increase in risk of gallbladder cancer |
Human | CYP7A1 | 1581 | cytochrome P450, family 7, subfamily A, polypeptide 1 | the association of A-204C variation of CYP7A1 gene promoter polymorphism in gallbladder cancer patients, gallstone patients and healthy subjects |
Human | CYP1A1 | 1543 | cytochrome P450, family 1, subfamily A, polypeptide 1 | The CC genotype of CYP1A1 was significantly associated with a risk of gallbladder cancer in a north Indian population polymorphisms in cyp1a1 is associated with risk of gall bladder cancer |
Human | CTGF | 1490 | connective tissue growth factor | An unbiased analysis of the gallblader cancer transcriptome by serial analysis of gene expression has identified CTGF expression as a predictive biomarker of favorable prognosis in gallbladder cancer |
Human | CDKN2A | 1029 | cyclin-dependent kinase inhibitor 2A | Homozygous deletion, a combination of LOH and promoter hypermethylation, and multiple LOH are major mechanisms of p16 inactivation in gallbladder cancer |
Human | CDH1 | 999 | cadherin 1, type 1, E-cadherin (epithelial) | Loss of E-cadherin expression followed by expression of the mts1 gene may be an important event for increasing cell proliferation, motility and invasion activity in the progression of gallbladder cancer Both expression of E-cadherin and its membranous localization are required for well-differentiated-type morphogenesis in gallbladder cancer cells |
Human | APOB | 338 | apolipoprotein B | Title:Apolipoprotein B-100 XbaI gene polymorphism in gallbladder cancer.|Association:Not Found|Conclusion:Not Found There seems to be an association between APOB Xbai polymorphism and gallbladder cancer The X(+),D haplotype of APOB is associated with increased risk for development of gallbladder cancer and the risk is not modified in the presence of gallstones |