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Details
Link-It Detail - Disease - Folic Acid Deficiency
Debug Stats
  • ### Total Build Time: 29 ms 27.502 KB
  • CONCEPT_NAME gt=1 ms Completed: 1 ms rowSize= 394 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 817 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=1 ms Completed: 1 ms rowSize= 188 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=2 ms Completed: 2 ms rowSize= 556 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 1.521 KB
  • CONCEPT_RELATIONSHIPS gt=19 ms Completed: 19 ms rowSize= 12.991 KB
  • CONCEPT_GENES gt=5 ms Completed: 5 ms rowSize= 9.891 KB
  • CONCEPT_XREFS gt=0 Completed: 0 ms rowSize= 1.155 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Reload Stats
Disease (2)
Folic Acid Deficiency C0016412
Acid Deficiencies, Folic
Definition (1)
A nutritional condition produced by a deficiency of FOLIC ACID in the diet. Many plant and animal tissues contain folic acid, abundant in green leafy vegetables, yeast, liver, and mushrooms but destroyed by long-term cooking. Alcohol interferes with its intermediate metabolism and absorption. Folic acid deficiency may develop in long-term anticonvulsant therapy or with use of oral contraceptives. This deficiency causes anemia, macrocytic anemia, and megaloblastic anemia. It is indistinguishable from vitamin B 12 deficiency in peripheral blood and bone marrow findings, but the neurologic lesions seen in B 12 deficiency do not occur. (Merck Manual, 16th ed)
Semantic Types (1)
Disease or Syndrome (T047)
Parents (1)
img Vitamin B Deficiency C0042850
Ancestral Roots
RootRoot Plus OneDepthParent
img Nutritional and Metabolic Diseases C0028715img Nutrition Disorders C00287097img Vitamin B Deficiency C0042850
Relationships (55)

Relation Types:
diso_​to_​anat : 6
diso_​to_​chem : 26
diso_​to_​diso : 18
diso_​to_​phen : 2
diso_​to_​phys : 3


Relationships:
none : 36
isa : 1
may_​prevent : 9
may_​treat : 8
permuted_​term_​of : 1
Page Size
Current 25
  Page 1 of 3
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_CHEM144img Folic Acid C0016410
DISO_to_DISO107img Complication Aspects C1171258
DISO_to_DISO105img Complication Aspects C1171258
DISO_to_CHEM94img Folic Acid C0016410
DISO_to_ANAT76img In Blood C0005768
DISO_to_DISO65img CYANOCOBALAMIN DEFICIENCY C0042847
DISO_to_ANAT60img In Blood C0005768
DISO_to_DISO52img CYANOCOBALAMIN DEFICIENCY C0042847
DISO_to_PHEN38img genetic aspects C0017399
DISO_to_CHEM37img Homocysteine C0019878
DISO_to_DISO27img Neural Tube Defects C0027794
DISO_to_PHEN25img genetic aspects C0017399
DISO_to_DISO24img HOMOCYSTEINEMIA C0598608
DISO_to_CHEM23img Vitamin B Complex C0042849
DISO_to_DISO18img Neural Tube Defects C0027794
DISO_to_DISO17img Anemia C0002871
DISO_to_CHEM16img Homocysteine C0019878
DISO_to_DISO16img HOMOCYSTEINEMIA C0598608
DISO_to_PHYS16img DNA Methylation C0376452
DISO_to_PHYS16img Nutritional Status C0392209
DISO_to_CHEM15img Vitamin B 12 C0042845
DISO_to_ANAT14img Brain C0006104
DISO_to_CHEM14img Methylenetetrahydrofolate Reductase (NADPH2) C0066357
DISO_to_DISO13img Pregnancy Complications C0032962
DISO_to_ANAT12img Erythrocytes C0014792
Genes (8)

Species:
human : 8
SpeciesGeneGeneIdGene NameEvidence
HumanMTHFD1L25902methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
img GENERIF, Score=1000, Pubmed Id: 15068241, UMLKSK CUI: C0016412
HumanTYMS7298thymidylate synthetase
img GENERIF, Score=1000, Pubmed Id: 15817609, UMLKSK CUI: C0016412
HumanTGFB17040transforming growth factor, beta 1
img GENERIF, Score=1000, Pubmed Id: 16111879, UMLKSK CUI: C0016412
HumanSLC19A16573solute carrier family 19 (folate transporter), member 1
img GENERIF, Score=1000, Pubmed Id: 12144527, UMLKSK CUI: C0016412
HumanMTHFR4524methylenetetrahydrofolate reductase (NAD(P)H)
img GENERIF, Score=1000, Pubmed Id: 12666851, UMLKSK CUI: C0016412
HumanIGF13479insulin-like growth factor 1 (somatomedin C)
img GENERIF, Score=1000, Pubmed Id: 16111879, UMLKSK CUI: C0016412
HumanHLA-DQB13119
img OMIM, Score=1000, UMLKSK CUI: C0016412
img OMIM, Score=1000, UMLKSK CUI: C0016412
HumanHLA-DQA13117
img OMIM, Score=1000, UMLKSK CUI: C0016412
img OMIM, Score=1000, UMLKSK CUI: C0016412
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0016412Folic Acid Deficiency0self