Debug Stats | ### Total Build Time: 23 ms 29.756 KB CONCEPT_NAME gt=1 ms Completed: 1 ms rowSize= 322 bytesCONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytesCONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 269 bytes- Skipping details on:
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CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 14 bytes- Skipping details on:
CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes CONCEPT_PARENTS gt=0 Completed: 0 ms rowSize= 7 bytesCONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytesCONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 15 bytesCONCEPT_RELATIONSHIPS gt=11 ms Completed: 11 ms rowSize= 11.940 KBCONCEPT_GENES gt=9 ms Completed: 9 ms rowSize= 16.021 KBCONCEPT_XREFS gt=1 ms Completed: 1 ms rowSize= 1.146 KBCONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes- Reload Stats
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Relationships (25)
Relation Types: diso_to_anat : 8 diso_to_diso : 17
Relationships: associated_with : 1 is_abnormal_cell_of_disease : 3 is_finding_of_disease : 1 is_normal_cell_origin_of_disease : 2 is_normal_tissue_origin_of_disease : 2 is_not_finding_of_disease : 1 is_not_normal_cell_origin_of_disease : 1 isa : 12 permuted_term_of : 1 used_for : 1 | |
DISO_to_ANAT | | is_normal_cell_origin_of_disease |
Cell of connective tissue C0009781 | DISO_to_ANAT | | is_normal_tissue_origin_of_disease |
Connective and Soft Tissue C1516798 | DISO_to_ANAT | | is_normal_cell_origin_of_disease |
Fibroblasts C0016030 | DISO_to_ANAT | | is_abnormal_cell_of_disease |
Neoplastic Cell C0597032 | DISO_to_ANAT | | is_abnormal_cell_of_disease |
Neoplastic Connective and Soft Tissue Cell C1513942 | DISO_to_ANAT | | is_abnormal_cell_of_disease |
Neoplastic Fibroblast C1709175 | DISO_to_ANAT | | is_not_normal_cell_origin_of_disease |
Nerve Cell, Neuroepithelial Cell, and Supporting Cell of the Nervous System C1518293 | DISO_to_ANAT | | is_normal_tissue_origin_of_disease |
soft tissue C0225317 | DISO_to_DISO | | isa |
Aggressive Fibromatoses C0079218 | DISO_to_DISO | | isa |
Aponeurotic fibroma C0553647 | DISO_to_DISO | | isa |
Cicatricial fibromatosis C0334167 | DISO_to_DISO | | isa |
Diffuse fibromatosis C1265989 | DISO_to_DISO | | used_for |
Fibroma C0016045 | DISO_to_DISO | | permuted_term_of |
Fibromatoses C0016048 | DISO_to_DISO | | associated_with |
Fibromatoses, Gingival C0016049 | DISO_to_DISO | | isa |
Fibromatosis colli C0549175 | DISO_to_DISO | | isa |
Focal fibromatosis C1265988 | DISO_to_DISO | | isa |
Infantile Fibromatosis, Non-Desmoid Type C3274592 | DISO_to_DISO | | isa |
Infantile digital fibromatosis C1318562 | DISO_to_DISO | | is_finding_of_disease |
Infiltrative Growth C1512752 | DISO_to_DISO | | isa |
Musculo-aponeurotic fibromatosis C1297884 | DISO_to_DISO | | isa |
Myofibromatosis C0206648 | DISO_to_DISO | | isa |
Recurrent fibromatosis C1265990 | DISO_to_DISO | | isa |
Superficial Fibromatosis C0406571 | DISO_to_DISO | | is_not_finding_of_disease |
Well-Circumscribed Lesion C1707398 |
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Genes (14)
Species: human : 13 mouse : 1 | |
Mouse | JUND | 3727 | jun D proto-oncogene | Overexpression of junB or c-jun by transfection into the mild fibromatosis stage elicited changes in cell shape and anchorage independence, whereas junD did not. | Human | TCF7L1 | 83439 | transcription factor 7-like 1 (T-cell specific, HMG-box) | Tcf-3 expression and beta-catenin mediated transcriptional activation in aggressive fibromatosis (desmoid tumour). | Human | CLDN1 | 9076 | claudin 1 | Claudin-1 expression was not noted in any cases of dermatofibrosarcoma protuberans, low-grade fibromyxoid sarcoma, desmoplastic fibroblastoma, or fibromatosis. | Human | WISP1 | 8840 | WNT1 inducible signaling pathway protein 1 | In particular, ADAM12, WISP-1, SOX-11, and fibroblast activation protein-alpha were uniquely overexpressed in aggressive fibromatosis compared with expression in normal tissues. | Human | ADAM12 | 8038 | ADAM metallopeptidase domain 12 | In particular, ADAM12, WISP-1, SOX-11, and fibroblast activation protein-alpha were uniquely overexpressed in aggressive fibromatosis compared with expression in normal tissues. | Human | TIMP2 | 7077 | TIMP metallopeptidase inhibitor 2 | Alteration in expression of MMP-1 and MMP-2 but not TIMP-1 and TIMP-2 in hereditary gingival fibromatosis is mediated by TGF-beta 1 autocrine stimulation. | Human | TIMP1 | 7076 | TIMP metallopeptidase inhibitor 1 | Alteration in expression of MMP-1 and MMP-2 but not TIMP-1 and TIMP-2 in hereditary gingival fibromatosis is mediated by TGF-beta 1 autocrine stimulation. | Human | TGFB3 | 7043 | transforming growth factor, beta 3 | Absorbance measurements of the positive cell populations showed that the level of expression was significantly higher for TGF-beta1 in hereditary gingival fibromatosis (P<0.002) and significantly lower for TGF-beta3 in DIGO (P<0.03). | Human | TGFB2 | 7042 | transforming growth factor, beta 2 | Cells expressing TGF-beta2 were present at control levels in DIGO but were significantly reduced in hereditary gingival fibromatosis (P<0.02). | Human | SOX11 | 6664 | SRY (sex determining region Y)-box 11 | In particular, ADAM12, WISP-1, SOX-11, and fibroblast activation protein-alpha were uniquely overexpressed in aggressive fibromatosis compared with expression in normal tissues. | Human | JUNB | 3726 | jun B proto-oncogene | Overexpression of junB or c-jun by transfection into the mild fibromatosis stage elicited changes in cell shape and anchorage independence, whereas junD did not. | Human | CKM | 1158 | creatine kinase, muscle | Gingival fibroblasts from normal subjects (A), and from patients with periodontitis (B) or fibromatosis (C), exhibited CK-MM (muscle form) as a predominant isoenzyme and CK-BB (brain form) as a minor fraction. | Human | APC | 324 | adenomatous polyposis coli | Infiltrative fibromatosis of mesentery | Human | ACTC1 | 70 | actin, alpha, cardiac muscle 1 | The expression of alpha smooth muscle actin, muscle specific actin, desmin, h-caldesmon, and calponin was studied immunohistochemically in the following soft tissue and bone tumours and tumour-like lesions: muscle fibromatosis, inflammatory pseudotumours, chondroblastoma, enchondroma, chondrosarcoma, fibrous dysplasia, ossifying myositis, osteoblastoma, convential osteosarcoma, leiomyoma and leiomyosarcoma. |
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