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Genes (26)
Species: human : 26 | |
Human | MYLK3 | 91807 | myosin light chain kinase 3 | Moreover, the stress fiber staining pattern is periodic in well-spread gerbil fibroma cells and experiments have demonstrated that myosin light chain kinase appears to have the same periodic distribution as myosin but an antiperiodic distribution relative to alpha-actinin. | Human | TCF7L1 | 83439 | transcription factor 7-like 1 (T-cell specific, HMG-box) | INFERRED, Score=800, UMLKSK CUI: C0016045 | Human | CDC73 | 79577 | cell division cycle 73 | INFERRED, Score=800, UMLKSK CUI: C0016045 | Human | CTNNBIP1 | 56998 | catenin, beta interacting protein 1 | INFERRED, Score=800, UMLKSK CUI: C0016045 | Human | REEP5 | 7905 | receptor accessory protein 5 | INFERRED, Score=800, UMLKSK CUI: C0016045 | Human | WT1 | 7490 | Wilms tumor 1 | INFERRED, Score=800, UMLKSK CUI: C0016045 | Human | TGFB1 | 7040 | transforming growth factor, beta 1 | INFERRED, Score=800, UMLKSK CUI: C0016045 | Human | S100A9 | 6280 | S100 calcium binding protein A9 | Antibodies to XIIIa, CD34, S-100 protein, and macrophage antigen (MAC 387) were tested on formalin-fixed, paraffin-embedded tissue sections from normal mucosa, peripheral fibroma (PF), peripheral ossifying fibroma (POF), peripheral giant cell granuloma (PGCG), pyogenic granuloma (PG), lymphangioma (La), benign fibrous histiocytoma (BFH), idiopathic histiocytosis (IH), angiofibroma (Af) using an ABC immunoperoxidase technique. Tissues from four irritation fibromas and three squamous cell carcinomas were studied by means of double immunofluorescent staining techniques in which the detection of FXIII A was combined with a reaction with CD14 (recognizing a monocyte/macrophage differentiation marker antigen), Mac 387 (reacting with a special subset of macrophages), anti-HLA-DR, Ki-M7 (labelling phagocytosing macrophages) or Ki-67 (visualizing a nuclear antigen associated with cell proliferation) monoclonal antibodies. METHODS: Formalin-fixed, paraffin-embedded tissues from fibrous papules (FP, 20), dermatofibromas (DF, 20), dermatofibrosarcoma protuberans (DFSP, 5), atypical fibroxanthomas (AFX, 5), oral fibromas (3), digital fibroma (1), and dermatomyofibroma (1) were evaluated with antibodies to S100A6, S100B, factor XIIIa, and MAC387 using a one-hour capillary action-based immunohistochemical procedure. | Human | PTCH1 | 5727 | patched 1 | Patched gene is epigenetically regulated in ovarian dermoids and fibromas, but not in basocellular carcinomas | Human | PDGFRB | 5159 | platelet-derived growth factor receptor, beta polypeptide | INFERRED, Score=800, UMLKSK CUI: C0016045 | Human | SERPINE1 | 5054 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | INFERRED, Score=800, UMLKSK CUI: C0016045 | Human | NTRK3 | 4916 | neurotrophic tyrosine kinase, receptor, type 3 | INFERRED, Score=800, UMLKSK CUI: C0016045 | Human | NRGN | 4900 | neurogranin (protein kinase C substrate, RC3) | Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of W-7; using pressure microinjection, we introduced up to a 100-fold excess of calmodulin over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. | Human | MMP13 | 4322 | matrix metallopeptidase 13 (collagenase 3) | INFERRED, Score=800, UMLKSK CUI: C0016045 | Human | MMP12 | 4321 | matrix metallopeptidase 12 (macrophage elastase) | INFERRED, Score=800, UMLKSK CUI: C0016045 | Human | MKI67 | 4288 | antigen identified by monoclonal antibody Ki-67 | INFERRED, Score=800, UMLKSK CUI: C0016045 | Human | CD99 | 4267 | CD99 molecule | Solitary sclerotic fibroma of skin: a possible link with pleomorphic fibroma with immunophenotypic expression for O13 (CD99) and CD34. Nuchal-type fibroma is positive for CD34 and CD99. | Human | L1CAM | 3897 | L1 cell adhesion molecule | INFERRED, Score=800, UMLKSK CUI: C0016045 | Human | KRT1 | 3848 | keratin 1 | The expression of CK1/10 in the epithelial basal and suprabasal layers was significantly higher in OLP than in fibromas. The expression of heat shock proteins HSP60 and HSP70 and cytokeratins CK1/10 and CK7/18 were compared in epithelium of oral lichen planus (OLP) lesions and oral fibromas using an avidin-biotin-peroxidase complex (ABC) immunohistochemical method. | Human | KIT | 3815 | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | INFERRED, Score=800, UMLKSK CUI: C0016045 | Human | IGFBP6 | 3489 | insulin-like growth factor binding protein 6 | INFERRED, Score=800, UMLKSK CUI: C0016045 | Human | CYP11A1 | 1583 | cytochrome P450, family 11, subfamily A, polypeptide 1 | Aromatase, 17 alpha-hydroxylase, and cholesterol side-chain cleavage P-450 cytochromes (P-450AROM, P-450(17 alpha,) and P-450SCC, respectively) were immunohistochemically localized in nine granulosa cell tumors, 15 thecomas, ten Sertoli-Leydig cell tumors, two steroid cell tumors, five fibromas, and five sclerosing stromal tumors. | Human | CTNNB1 | 1499 | catenin (cadherin-associated protein), beta 1, 88kDa | INFERRED, Score=800, UMLKSK CUI: C0016045 | Human | CD14 | 929 | CD14 molecule | Tissues from four irritation fibromas and three squamous cell carcinomas were studied by means of double immunofluorescent staining techniques in which the detection of FXIII A was combined with a reaction with CD14 (recognizing a monocyte/macrophage differentiation marker antigen), Mac 387 (reacting with a special subset of macrophages), anti-HLA-DR, Ki-M7 (labelling phagocytosing macrophages) or Ki-67 (visualizing a nuclear antigen associated with cell proliferation) monoclonal antibodies. | Human | CCND1 | 595 | cyclin D1 | INFERRED, Score=800, UMLKSK CUI: C0016045 |
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