Human | TNFRSF12A | 51330 | tumor necrosis factor receptor superfamily, member 12A | TWEAK and Fn14 are expressed in atherosclerotic plaques and could be novel mediators of atherosclerosis |
Human | GP6 | 51206 | glycoprotein VI (platelet) | results indicate that morphologically diverse collagen type I- and collagen type III-containing structures in lipid-rich atherosclerotic plaques stimulate thrombus formation by activating platelet glycoprotein VI (GPVI) |
Human | GPR132 | 29933 | G protein-coupled receptor 132 | In atherosclerotic plaques of human coronary arterial specimens, G2A is expressed by macrophages within the lipid-rich plaques, whereas no immunoreactivity of G2A is observed in fibrous plaques where macrophages do not exist |
Human | ANKRD1 | 27063 | ankyrin repeat domain 1 (cardiac muscle) | CARP expression is observed by in situ hybridization in endothelial cells lining human atherosclerotic plaques, whereas lesion macrophages are devoid of CARP; it is induced by activin A in cultured intimal smooth muscle cells |
Human | ADAMTS8 | 11095 | ADAM metallopeptidase with thrombospondin type 1 motif, 8 | ADAMTS-4 and -8 are inflammatory regulated enzymes expressed in macrophage-rich areas of atherosclerotic plaques |
Human | ADAMTS4 | 9507 | ADAM metallopeptidase with thrombospondin type 1 motif, 4 | ADAMTS-4 and -8 are inflammatory regulated enzymes expressed in macrophage-rich areas of atherosclerotic plaques |
Human | TNFSF14 | 8740 | tumor necrosis factor (ligand) superfamily, member 14 | LIGHT (TNFSF14),5 its membrane-anchored ligand, was also present in atheromatous lesions and highest in regions rich in macrophage-derived foam cells LIGHT could serve as a molecular link between lipid metabolism, inflammation, and thrombus formation, which are all features of atherosclerotic plaques |
Human | NR4A3 | 8013 | nuclear receptor subfamily 4, group A, member 3 | NOR-1 is over-expressed in human atherosclerotic plaques and in porcine arteries subjected to angioplasty, is induced by growth factors in vascular cells and it has been involved in cell migration and proliferation Neuron-derived orphan receptor-1 (NOR-1) is a transcription factor over-expressed in human atherosclerotic plaques that is involved in vascular smooth muscle cell proliferation |
Human | PLA2G7 | 7941 | phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) | If Lp-PLA(2) independently influences clinical events, it does so by promoting atherosclerotic plaque instability rather than by stimulating atherogenesis |
Human | UCP2 | 7351 | uncoupling protein 2 (mitochondrial, proton carrier) | Mitochondrial UCP2 in circulating monocytes may prevent excessive accumulation of monocytes/macrophages in the arterial wall, thereby reducing atherosclerotic plaque formation |
Human | TFPI | 7035 | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | in atherosclerotic plaques, a decrease of TFPI contributes to a shift toward increased thrombotic potential in dyslipidemic patients |
Human | CX3CL1 | 6376 | chemokine (C-X3-C motif) ligand 1 | a subset of mononuclear cells expresses high levels of fractalkine in human coronary atherosclerotic plaques and smooth muscle cells within the neointima express the fractalkine receptor CX3CR1 |
Human | S100A9 | 6280 | S100 calcium binding protein A9 | S100A8 and S100A9 in atherosclerotic plaque and calcifying matrix vesicles may significantly influence redox- and Ca2+-dependent processes during atherogenesis |
Human | S100A8 | 6279 | S100 calcium binding protein A8 | S100A8 and S100A9 in atherosclerotic plaque and calcifying matrix vesicles may significantly influence redox- and Ca2+-dependent processes during atherogenesis |
Human | PTX3 | 5806 | pentraxin 3, long | PTX3 is produced in advanced atherosclerotic plaques principally by macrophages and endothelial cells and may contribute to the pathogenesis of atherosclerosis |
Human | PTGER4 | 5734 | prostaglandin E receptor 4 (subtype EP4) | EP4 overexpression is associated with enhanced inflammatory reaction in atherosclerotic plaques |
Human | PTAFR | 5724 | platelet-activating factor receptor | presence of functional PAF-R in arterial spindle-shaped smooth muscle cells of synthetic phenotype may be important for their migration from the media into the intima and atherosclerotic plaques formation |
Human | PLIN1 | 5346 | perilipin 1 | We show the presence and induction of perilipin in atheroma |
Human | SERPINE2 | 5270 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | Macrophages and platelets are the major source of protease nexin-1 in human atherosclerotic plaque |
Human | PCSK5 | 5125 | proprotein convertase subtilisin/kexin type 5 | furin and PC5 play a role in a MT-MMP-MMP-2 proteolytic cascade, involving provision of macrophage MT1-MMP for the activation of pro-MMP-2; furin and PC5 are expressed in monocytes and colocalize with MT1-MMP in macrophages in the atherosclerotic plaque |
Human | PAPPA | 5069 | pregnancy-associated plasma protein A, pappalysin 1 | Elevated serum PAPP-A levels represent a potential marker of the degree of echogenicity of carotid atherosclerotic plaques in asymptomatic hyperlipidemic patients at high cardiovascular risk |
Human | FURIN | 5045 | furin (paired basic amino acid cleaving enzyme) | furin and PC5 play a role in a MT-MMP-MMP-2 proteolytic cascade, involving provision of macrophage MT1-MMP for the activation of pro-MMP-2; furin and PC5 are expressed in monocytes and colocalize with MT1-MMP in macrophages in the atherosclerotic plaque |
Human | MPO | 4353 | myeloperoxidase | myeloperoxidase levels are increased in complicated atherosclerotic plaques and in plasma level of patients with carotid atherosclerosis |
Human | MMP14 | 4323 | matrix metallopeptidase 14 (membrane-inserted) | furin and PC5 play a role in a MT-MMP-MMP-2 proteolytic cascade, involving provision of macrophage MT1-MMP for the activation of pro-MMP-2; furin and PC5 are expressed in monocytes and colocalize with MT1-MMP in macrophages in the atherosclerotic plaque |
Human | MMP9 | 4318 | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | matrix metalloproteinase 9 (MMP-9)levels are increased in complicated atherosclerotic plaques and in plasma level of patients with carotid atherosclerosis MMP9 is expressed in the unstable coronary atherosclerotic plaque, as are its transcriptional and posttranscriptional regulators |