Human | CSAG2 | 728461 | CSAG family, member 2 | As the TRAG-3 gene is located on Xq28, which is the same locus as the MAGE gene family, we found a frequent synchronous expression pattern with TRAG-3 and MAGE-3 in esophageal cancer |
Human | MIR196A1 | 406972 | microRNA 196a-1 | demonstrated a novel mechanism of post-transcriptional regulation of ANXA1 expression and identified miR-196a as a marker of esophageal cancer |
Human | TMPRSS11A | 339967 | transmembrane protease, serine 11A | findings indicate that ECRG1 may be a candidate tumor suppressor gene for esophageal cancer involved in cell-cycle control |
Human | GATA5 | 140628 | GATA binding protein 5 | Frequent silencing of GATA-4 and GATA-5 in human esophageal neoplasia is associated with gene promoter hypermethylation |
Human | EMILIN3 | 90187 | elastin microfibril interfacer 3 | Might play important roles in carcinogenesis of esophageal cancer |
Human | SPINK7 | 84651 | serine peptidase inhibitor, Kazal type 7 (putative) | Short tandem repeat polymorphism in a novel esophageal cancer-related gene (ECRG2) implicates susceptibility to esophageal cancer Data suggest that the physical interaction of esophageal cancer related gene 2 (ECRG2) and metallothionein 2A (MT2A) may play an important role in the carcinogenesis of esophageal cancer genetically fixed short tandem repeat polymorphism TCA3/TCA3 in exon 4 of ECRG2 is associated with poor clinical outcome in surgically treated esophageal cancer patients and might be a potential prognostic marker |
Human | C2orf40 | 84417 | chromosome 2 open reading frame 40 | Significantly lower expression of esophageal cancer-related gene 4 is associated with esophageal squamous cell carcinoma |
Human | PDCD1LG2 | 80380 | programmed cell death 1 ligand 2 | Data suggest that PD-L2 status may be a new predictor of prognosis for patients with esophageal cancer |
Human | RNF34 | 80196 | ring finger protein 34, E3 ubiquitin protein ligase | a novel gene, hRFI, preferentially expressed in esophageal cancer (hRFI) |
Human | RSRC2 | 65117 | arginine/serine-rich coiled-coil 2 | RSRC2 might play a role in cell proliferation and progression of esophageal cancer |
Human | IL21 | 59067 | interleukin 21 | Expression of interleukin-21 and -23 in human esophageal tumors produced antitumor effects in nude mice. Expressed IL-21 or IL-23 in human esophageal tumors can produce antitumor effects in a T cell-defective condition. Esophageal tumor T.Tn cells were retrovirally transduced with the IL-21 gene (T.Tn/IL-21) or the p19-linked p40 genes (T.Tn/IL-23). |
Human | ADAMTS9 | 56999 | ADAM metallopeptidase with thrombospondin type 1 motif, 9 | Downregulation of ADAMTS9 was also found in 43.5 and 47.6% of primary esophageal tumor tissues from Hong Kong and from the high-risk region of Henan, respectively. this study identifies and provides functional evidence for a critical region associated with tumor suppression on 3p14.2 and provides the first evidence that ADAMTS9, mapping to this region, may contribute to esophageal cancer development |
Human | CHFR | 55743 | checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase | expression is downregulated by CpG island hypermethylation in esophageal cancer |
Human | LRP1B | 53353 | low density lipoprotein receptor-related protein 1B | Genomic PCR experiments revealed homozygous deletions of LRP1B in additional ESC cell lines (total, 6 of 43; 14.0%) and in primary esophageal tumors (30 of 70; 42.9%). Methylation of LRP1B was also detected in primary esophageal tumors. |
Human | SPA17 | 53340 | sperm autoantigenic protein 17 | In conclusion, the study demonstrates expression of Sp17 protein in esophageal tumor as well as dysplastic tissues, suggesting it to be an early event in the development of ESCC. Overexpression of sperm protein 17 is associated with esophageal cancer |
Human | WWOX | 51741 | WW domain containing oxidoreductase | |
Human | IL23A | 51561 | interleukin 23, alpha subunit p19 | Expressed IL-21 or IL-23 in human esophageal tumors can produce antitumor effects in a T cell-defective condition. |
Human | IL22 | 50616 | interleukin 22 | Expressed IL-21 or IL-23 in human esophageal tumors can produce antitumor effects in a T cell-defective condition. Esophageal tumor T.Tn cells were retrovirally transduced with the IL-21 gene (T.Tn/IL-21) or the p19-linked p40 genes (T.Tn/IL-23). Expression of interleukin-21 and -23 in human esophageal tumors produced antitumor effects in nude mice. |
Human | DEC1 | 50514 | deleted in esophageal cancer 1 | |
Human | CD274 | 29126 | CD274 molecule | Data suggest that PD-L1 status may be a new predictor of prognosis for patients with esophageal cancer |
Human | MLH3 | 27030 | mutL homolog 3 (E. coli) | Mutations of Mlh3 may work together with other genes in an accumulated manner and result in an increased risk of esophageal tumor |
Human | PABPC1 | 26986 | poly(A) binding protein, cytoplasmic 1 | In esophageal cancer, reduced expression of PABPC1 was correlated with local tumor progression and poor prognosis after surgery |
Human | LATS2 | 26524 | large tumor suppressor kinase 2 | These results indicated that the LATS2 gene is inactivated in only a small part of esophageal tumors, if any. We therefore screened esophageal tumor cell lines and tumor tissues to detect tumor specific mutations of the LATS2 gene. |
Human | TMEFF2 | 23671 | transmembrane protein with EGF-like and two follistatin-like domains 2 | Hypermethylation of p16, RUNX3, and HPP1 in Barreett exophagus may represent independent risk factors for the progression of Barrett esophagus to esophageal cancer |
Human | LZTS1 | 11178 | leucine zipper, putative tumor suppressor 1 | The gene LZTS1 has been mapped to the 8p22 through p23 region and identified as a potential tumor suppressor based on loss of heterozygosity studies using primary esophageal tumors. |