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Details
Link-It Detail - Disease - Eosinophilic Granuloma
Debug Stats
  • ### Total Build Time: 37 ms 33.349 KB
  • CONCEPT_NAME gt=4 ms Completed: 4 ms rowSize= 342 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 604 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 188 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=5 ms Completed: 5 ms rowSize= 1.812 KB
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=12 ms Completed: 12 ms rowSize= 9.173 KB
  • CONCEPT_RELATIONSHIPS gt=12 ms Completed: 12 ms rowSize= 14.307 KB
  • CONCEPT_GENES gt=3 ms Completed: 3 ms rowSize= 5.759 KB
  • CONCEPT_XREFS gt=1 ms Completed: 1 ms rowSize= 1.156 KB
  • CONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Eosinophilic Granuloma C0014461
Definition (1)
A clinical variant of Langerhans cell histiocytosis characterised by unifocal involvement of a bone (most often), skin, or lung. Patients are usually older children or adults usually presenting with a lytic bone lesion. The etiology is unknown. Morphologically, eosinophilic granuloma is characterised by the presence of Langerhans cells in a characteristic milieu which includes histiocytes, eosinophiles neutrophiles, and small, mature lymphocytes.
Semantic Types (1)
Pathologic Function (T046)
Parents (4)
img Bone Diseases C0005940
img Eosinophilia C0014457
img Granuloma C0018188
img Histiocytosis, Langerhans-Cell C0019621
Ancestral Roots
RootRoot Plus OneDepthParent
img Musculoskeletal Diseases C0026857img Bone Diseases C00059403img Bone Diseases C0005940
img Hemic and Lymphatic Diseases C0018981img Hematologic Diseases C00189395img Eosinophilia C0014457
img Pathological Conditions, Signs and Symptoms C0039058img Pathologic Processes C00306604img Granuloma C0018188
img Immune System Diseases C0021053img Immunoproliferative Disorders C00210705img Granuloma C0018188
img Hemic and Lymphatic Diseases C0018981img Lymphatic Diseases C00242285img Granuloma C0018188
img Respiratory Tract Diseases C0035242img Lung Diseases C00241155img Histiocytosis, Langerhans-Cell C0019621
img Hemic and Lymphatic Diseases C0018981img Lymphatic Diseases C00242285img Histiocytosis, Langerhans-Cell C0019621
Relationships (43)

Relation Types:
diso_​to_​anat : 11
diso_​to_​diso : 30
diso_​to_​phen : 2


Relationships:
none : 17
is_​abnormal_​cell_​of_​disease : 4
is_​associated_​anatomic_​site_​of : 1
is_​finding_​of_​disease : 6
is_​normal_​cell_​origin_​of_​disease : 3
is_​normal_​tissue_​origin_​of_​disease : 1
is_​not_​finding_​of_​disease : 4
is_​not_​molecular_​abnormality_​of_​disease : 2
may_​be_​finding_​of_​disease : 3
permuted_​term_​of : 1
replaces : 1
Page Size
Current 25
  Page 1 of 2
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_DISO22img Complication Aspects C1171258
DISO_to_DISO17img Complication Aspects C1171258
DISO_to_DISO13img Bone Diseases C0005940
DISO_to_DISO10img Spinal Diseases C0037933
DISO_to_DISO8img Orbital Diseases C0029182
DISO_to_DISO7img Disease, Mandibular C0024689
DISO_to_DISO7img Histiocytosis, Langerhans-Cell C0019621
DISO_to_DISO7img Oral Ulcer C0149745
DISO_to_DISO7img Orbital Diseases C0029182
DISO_to_DISO7img Spinal Diseases C0037933
DISO_to_ANAT6img Bone structure of cranium C0037303
DISO_to_DISO6img CAT DIS C0007350
DISO_to_DISO6img Histiocytosis, Langerhans-Cell C0019621
DISO_to_ANAT5img Bone structure of cranium C0037303
DISO_to_DISO5img Dermatologic disorders C0037274
DISO_to_DISO5img Lung Diseases C0024115
DISO_to_DISO5img Oral Ulcer C0149745
DISO_to_ANATis_normal_tissue_origin_of_diseaseimg HEMOLYMPHORETICULAR TISSUE C1512398
DISO_to_ANATis_associated_anatomic_site_ofimg Hematopoietic and Lymphatic System C1512394
DISO_to_ANATis_normal_cell_origin_of_diseaseimg Hematopoietic and Lymphoid Cell C1512385
DISO_to_ANATis_normal_cell_origin_of_diseaseimg Histiocytic and Dendritic Cell C1708370
DISO_to_ANATis_normal_cell_origin_of_diseaseimg Langerhans Cells C0023005
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Cell C0597032
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Hematopoietic and Lymphoid Cell C1513983
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Histiocytic and Dendritic Cell C1709179
Genes (2)

Species:
human : 2
SpeciesGeneGeneIdGene NameEvidence
HumanRNASE36037ribonuclease, RNase A family, 3
img NCI, Score=801, Pubmed Id: 7956407, UMLKSK CUI: C0014461
img NCI, Score=801, Pubmed Id: 7956407, UMLKSK CUI: C0014461
img NCI, Score=801, Pubmed Id: 7956407, UMLKSK CUI: C0014461
img NCI, Score=801, Pubmed Id: 7956407, UMLKSK CUI: C0014461
img NCI, Score=801, Pubmed Id: 7956407, UMLKSK CUI: C0014461
HumanA2M2alpha-2-macroglobulin
img NCI, Score=801, Pubmed Id: 3307293, UMLKSK CUI: C0014461
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0014461Eosinophilic Granuloma0self