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Details
Link-It Detail - Disease - Endodermal Sinus Tumor
Debug Stats
  • ### Total Build Time: 29 ms 50.794 KB
  • CONCEPT_NAME gt=3 ms Completed: 3 ms rowSize= 342 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 695 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=1 ms Completed: 1 ms rowSize= 187 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=2 ms Completed: 2 ms rowSize= 548 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=2 ms Completed: 2 ms rowSize= 1.497 KB
  • CONCEPT_RELATIONSHIPS gt=6 ms Completed: 6 ms rowSize= 13.894 KB
  • CONCEPT_GENES gt=14 ms Completed: 14 ms rowSize= 32.481 KB
  • CONCEPT_XREFS gt=1 ms Completed: 1 ms rowSize= 1.156 KB
  • CONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Endodermal Sinus Tumor C0014145
Definition (1)
An unusual and aggressive tumor of germ-cell origin that reproduces the extraembryonic structures of the early embryo. It is the most common malignant germ cell tumor found in children. It is characterized by a labyrinthine glandular pattern of flat epithelial cells and rounded papillary processes with a central capillary (Schiller-Duval body). The tumor is rarely bilateral. Before the use of combination chemotherapy, the tumor was almost invariably fatal. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1189)
Semantic Types (1)
Neoplastic Process (T191)
Parents (1)
img Mesonephroma C0025490
Ancestral Roots
RootRoot Plus OneDepthParent
img Neoplasms C0027651img Neoplasms by Histologic Type C00276525img Mesonephroma C0025490
Relationships (47)

Relation Types:
diso_​to_​anat : 9
diso_​to_​diso : 37
diso_​to_​phen : 1


Relationships:
none : 24
eo_​disease_​maps_​to_​human_​disease : 1
is_​abnormal_​cell_​of_​disease : 4
is_​finding_​of_​disease : 1
is_​normal_​cell_​origin_​of_​disease : 1
is_​normal_​tissue_​origin_​of_​disease : 1
is_​not_​abnormal_​cell_​of_​disease : 1
isa : 9
may_​be_​finding_​of_​disease : 3
permuted_​term_​of : 1
related_​to : 1
Page Size
Current 25
  Page 1 of 2
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_DISO45img Ovarian Neoplasms C0919267
DISO_to_DISO25img Ovarian Neoplasms C0919267
DISO_to_DISO24img Testicular Neoplasms C0039590
DISO_to_DISO21img Complication Aspects C1171258
DISO_to_DISO20img Testicular Neoplasms C0039590
DISO_to_DISO17img Teratoma C0039538
DISO_to_DISO14img Complication Aspects C1171258
DISO_to_DISO13img Teratoma C0039538
DISO_to_ANAT12img In Blood C0005768
DISO_to_DISO11img Brain Neoplasms C0006118
DISO_to_PHEN11img genetic aspects C0017399
DISO_to_ANAT9img In Blood C0005768
DISO_to_DISO9img MULTIPLE PRIMARY NEOPL C0027663
DISO_to_DISO9img SEMINOMA C0036631
DISO_to_DISO9img Vaginal Neoplasms C0042258
DISO_to_DISO8img MEDIASTINAL NEOPL C0025063
DISO_to_DISO8img Stomach Neoplasms C0038356
DISO_to_DISO7img Brain Neoplasms C0006118
DISO_to_DISO7img COMPL NEOPL PREGN C0032966
DISO_to_DISO7img Germinoma C0206660
DISO_to_DISO7img Lung Neoplasms C0024121
DISO_to_DISO7img MULTIPLE PRIMARY NEOPL C0027663
DISO_to_DISO7img Neoplasm of retroperitoneum C0035358
DISO_to_DISO7img Vaginal Neoplasms C0042258
DISO_to_ANATis_normal_cell_origin_of_diseaseimg Germ Cells C0017471
Genes (23)

Species:
human : 23
SpeciesGeneGeneIdGene NameEvidence
HumanGGT2728441gamma-glutamyltransferase 2
img NCI, Score=801, Pubmed Id: 10487615, UMLKSK CUI: C0014145
HumanMSLN10232mesothelin
img NCI, Score=801, Pubmed Id: 14576474, UMLKSK CUI: C0014145
HumanCCNA18900cyclin A1
img NCI, Score=801, Pubmed Id: 12536081, UMLKSK CUI: C0014145
HumanMGCT8093male germ cell tumor
img NCI, Score=801, Pubmed Id: 8389653, UMLKSK CUI: C0014145
HumanVTN7448vitronectin
img NCI, Score=801, Pubmed Id: 2478355, UMLKSK CUI: C0014145
HumanSTK116794serine/threonine kinase 11
img OMIM, Score=1000, UMLKSK CUI: C0014145
img OMIM, Score=1000, UMLKSK CUI: C0014145
HumanPTPN135783protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
img NCI, Score=801, Pubmed Id: 16306258, UMLKSK CUI: C0014145
HumanMUC14582mucin 1, cell surface associated
img GENERIF, Score=1000, Pubmed Id: 15489654, UMLKSK CUI: C0014145
HumanMAGEA14100melanoma antigen family A, 1 (directs expression of antigen MZ2-E)
img NCI, Score=801, Pubmed Id: 10530563, UMLKSK CUI: C0014145
HumanLNPEP4012leucyl/cystinyl aminopeptidase
img NCI, Score=801, Pubmed Id: 2449757, UMLKSK CUI: C0014145
HumanLDHA3939lactate dehydrogenase A
img NCI, Score=801, Pubmed Id: 4005788, UMLKSK CUI: C0014145
img NCI, Score=801, Pubmed Id: 4005788, UMLKSK CUI: C0014145
HumanKIT3815v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
img OMIM, Score=1000, UMLKSK CUI: C0014145
img OMIM, Score=1000, UMLKSK CUI: C0014145
HumanGPC32719glypican 3
img GENERIF, Score=923, Pubmed Id: 18277882, UMLKSK CUI: C0014145
HumanGATA62627GATA binding protein 6
img NCI, Score=801, Pubmed Id: 12867597, UMLKSK CUI: C0014145
img NCI, Score=801, Pubmed Id: 12867597, UMLKSK CUI: C0014145
img GENERIF, Score=1000, Pubmed Id: 12867597, UMLKSK CUI: C0014145
HumanGATA42626GATA binding protein 4
img NCI, Score=801, Pubmed Id: 10595911, UMLKSK CUI: C0014145
HumanFGF82253fibroblast growth factor 8 (androgen-induced)
img NCI, Score=801, Pubmed Id: 11764380, UMLKSK CUI: C0014145
img NCI, Score=801, Pubmed Id: 11764380, UMLKSK CUI: C0014145
HumanFGF42249fibroblast growth factor 4
img NCI, Score=801, Pubmed Id: 11764380, UMLKSK CUI: C0014145
img NCI, Score=801, Pubmed Id: 11764380, UMLKSK CUI: C0014145
HumanFER2241fer (fps/fes related) tyrosine kinase
img NCI, Score=801, Pubmed Id: 6344553, UMLKSK CUI: C0014145
HumanNKX2-51482
img GENERIF, Score=1000, Pubmed Id: 18547965, UMLKSK CUI: C0014145
HumanCEBPB1051CCAAT/enhancer binding protein (C/EBP), beta
img NCI, Score=801, Pubmed Id: 15924879, UMLKSK CUI: C0014145
img NCI, Score=801, Pubmed Id: 15924879, UMLKSK CUI: C0014145
img NCI, Score=801, Pubmed Id: 15924879, UMLKSK CUI: C0014145
HumanAPEX1328APEX nuclease (multifunctional DNA repair enzyme) 1
img NCI, Score=801, Pubmed Id: 11205241, UMLKSK CUI: C0014145
img NCI, Score=801, Pubmed Id: 11205241, UMLKSK CUI: C0014145
HumanALPPL2251alkaline phosphatase, placental-like 2
img NCI, Score=801, Pubmed Id: 7543237, UMLKSK CUI: C0014145
HumanALPI248alkaline phosphatase, intestinal
img NCI, Score=801, Pubmed Id: 2445700, UMLKSK CUI: C0014145
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0014145Endodermal Sinus Tumor0self