Genes (23)
Species: human : 23 | |
Human | GGT2 | 728441 | gamma-glutamyltransferase 2 | There was no expression of GGT in any of the 17 seminomas or four dysgerminomas; whereas, 12/12 ovarian yolk sac tumours and 4/4 embryonal carcinomas of the testis were GGT-positive. | Human | MSLN | 10232 | mesothelin | Because of the strong mesothelin expression in nonmucinous carcinomas of the ovary, but not in a variety of tumors with which these lesions may be confused (eg, clear cell carcinoma of the ovary versus endodermal sinus tumor or renal cell carcinoma, clear cell type; transitional cell carcinoma of the ovary versus TCC of the urinary tract), immunostaining for this marker could be useful in establishing the differential diagnosis. | Human | CCNA1 | 8900 | cyclin A1 | Seminomas and yolk sac tumors expressed intermediate levels, whereas cyclin A1 expression was very low in mature teratomas. | Human | MGCT | 8093 | male germ cell tumor | RESULTS. Morphologically identifiable hematologic cells were found within the yolk sac tumor component of the MGCT in four of these patients. | Human | VTN | 7448 | vitronectin | We demonstrate here that endodermal sinus tumour cells, but not other cell types isolated from testicular teratomas, secrete the serum attachment protein, vitronectin (also known as serum-spreading factor, S-protein or epibolin), as well as fibronectin, laminin and type IV collagen, into serum-free medium. | Human | STK11 | 6794 | serine/threonine kinase 11 | Nonseminoma (embryonal carcinoma, teratoma, choriocarcinoma, endodermal sinus tumor) Elevated AFP (endodermal sinus tumor) | Human | PTPN13 | 5783 | protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) | Several additional differentially expressed genes were identified in teratomas (EGR1 and MMP7), yolk sac tumors (PTPN13 and FN1), and seminomas (NR6A1, DPPA4, and IRX1). | Human | MUC1 | 4582 | mucin 1, cell surface associated | Cytokeratin 7 and epithelial membrane antigen are essentially negative in yolk sac tumors but are diffusely positive in clear cell carcinomas and endometriod adenocarcinomas making them useful markers for differentiating YSTs from both CCCs and EACs | Human | MAGEA1 | 4100 | melanoma antigen family A, 1 (directs expression of antigen MZ2-E) | No embryonal carcinomas, yolk sac tumors, or teratomas contained MAGE-1 protein. | Human | LNPEP | 4012 | leucyl/cystinyl aminopeptidase | High AFP (FA) alone occurred in yolk sac tumors, HCG (PM) with AFP (FA) or PLAP (H7) in patients where the tumors had components of teratoma and/or embryonal carcinoma, moderately elevated levels of AFP (FA) and sometimes also HCG (PM) occurred. | Human | LDHA | 3939 | lactate dehydrogenase A | Although in recent years the evidence of an increase in serum lactate dehydrogenase isoenzyme-1 (LDH-1) in patients with germ cell tumor (GCT) has attracted attention, there have only been a few reports concerning yolk sac tumor (YST), which is a frequent type of GCT in childhood. Although in recent years the evidence of an increase in serum lactate dehydrogenase isoenzyme-1 (LDH-1) in patients with germ cell tumor (GCT) has attracted attention, there have only been a few reports concerning yolk sac tumor (YST), which is a frequent type of GCT in childhood. | Human | KIT | 3815 | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | Elevated AFP (endodermal sinus tumor) Nonseminoma (embryonal carcinoma, teratoma, choriocarcinoma, endodermal sinus tumor) | Human | GPC3 | 2719 | glypican 3 | GPC3 seems to be a promising diagnostic marker for differentiating yolk sac tumors from ovarian clear cell carcinomas | Human | GATA6 | 2627 | GATA binding protein 6 | Transcription factor GATA-6 is expressed in malignant endoderm of pediatric yolk sac tumors and in teratomas. GATA-6 was expressed in most yolk sac tumors examined and also in nonmalignant tissues including gut/respiratory epithelium, sebocytes, and neuroepithelium in mature and immature teratomas. GATA-6 was expressed in most yolk sac tumors examined and also in nonmalignant tissues including gut/respiratory epithelium, sebocytes, and neuroepithelium in mature and immature teratomas | Human | GATA4 | 2626 | GATA binding protein 4 | Transcription factor GATA-4 is expressed in pediatric yolk sac tumors. | Human | FGF8 | 2253 | fibroblast growth factor 8 (androgen-induced) | In addition, the Ki-67 labeling index showed extremely high mitogenic activity in embryonal carcinoma, yolk sac tumor, and choriocarcinoma, which are precisely the carcinomas with the highest expressions of FGF8, FGF4, and FGFR1. All cases of embryonal carcinoma (14 cases), yolk sac tumor (3 cases), and choriocarcinoma (3 cases) showed positive immunostaining for FGF8, FGF4, and FGFR1. | Human | FGF4 | 2249 | fibroblast growth factor 4 | All cases of embryonal carcinoma (14 cases), yolk sac tumor (3 cases), and choriocarcinoma (3 cases) showed positive immunostaining for FGF8, FGF4, and FGFR1. In addition, the Ki-67 labeling index showed extremely high mitogenic activity in embryonal carcinoma, yolk sac tumor, and choriocarcinoma, which are precisely the carcinomas with the highest expressions of FGF8, FGF4, and FGFR1. | Human | FER | 2241 | fer (fps/fes related) tyrosine kinase | Various epithelial cell types in embryonal carcinoma (EC), yolk sac tumours (YST) and teratoma (T) were FER positive. | Human | NKX2-5 | 1482 | | immunohistostaining was positive for Nkx2.5 in 6 of 9 patients with yolk sac tumor (YST), suggesting a certain function of Nkx2.5 in YST | Human | CEBPB | 1051 | CCAAT/enhancer binding protein (C/EBP), beta | Overexpression of C/EBP-beta in a rat yolk sac tumor cell line, AT-2-TC, increased production of AFP and other plasma proteins, including albumin, alpha-1-antitrypsin, hepatoglobin, and transferrin. We assumed a possible contribution of CCAAT/enhancer binding protein (C/EBP)-beta, a transcription factor implicated in the regulation of plasma proteins in the liver, to the regulation of AFP production and to the expression of other plasma proteins in yolk sac tumor cells because our immunohistochemical analysis revealed nuclear expression of C/EBP-beta in human yolk sac tumors. These results indicate that C/EBP-beta plays a role in the production of plasma proteins of yolk sac tumors. | Human | APEX1 | 328 | APEX nuclease (multifunctional DNA repair enzyme) 1 | We examined the role of Ape1/ref1 and a protein it regulates, hypoxia inducible factor 1 alpha (HIF-1 alpha) in pediatric yolk sac tumors. PATIENTS AND METHODS: Using an immunohistochemical evaluation, 16 pediatric yolk sac tumors were evaluated for Ape1/ref1 and HIF-1 alpha expression. | Human | ALPPL2 | 251 | alkaline phosphatase, placental-like 2 | Cytochemical staining for germ cell alkaline phosphatase was helpful in diagnosing seminoma in the cytologic examination, while the presence of hyaline globule or alpha-fetoprotein immunostaining as the cytologic diagnostic feature of yolk sac tumor were not necessarily found in fine needle aspiration cytology. | Human | ALPI | 248 | alkaline phosphatase, intestinal | The highest IAP levels were found in 2 yolk-sac tumors. |
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