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Genes (30)
Species: human : 30 | |
Human | NCF1 | 653361 | neutrophil cytosolic factor 1 | | Human | IL31 | 386653 | interleukin 31 | This study presents the first genetic risk factor for the nonatopic type of eczema and indicates a primary role of IL-31-induced pruritus in the initiation of this disease | Human | ATOD5 | 117188 | Dermatitis, atopic, 5 | Eczema (perifollicular accentuation) | Human | ATOD3 | 117187 | Dermatitis, atopic, 3 | Eczema (perifollicular accentuation) | Human | ATOD6 | 114477 | Dermatitis, atopic, 6 | Eczema (perifollicular accentuation) | Human | PHF11 | 51131 | PHD finger protein 11 | | Human | FOXP3 | 50943 | forkhead box P3 | | Human | IL21R | 50615 | interleukin 21 receptor | | Human | HAVCR1 | 26762 | hepatitis A virus cellular receptor 1 | | Human | SPINK5 | 11005 | serine peptidase inhibitor, Kazal type 5 | SPINK5 mutation confers a risk of eczema when maternally inherited but is not a major eczema risk factor; no interaction between the SPINK5 risk allele or the putative KLK7 risk allele and FLG mutations ws found | Human | PLA2G7 | 7941 | phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) | | Human | WAS | 7454 | Wiskott-Aldrich syndrome | | Human | TNF | 7124 | tumor necrosis factor | Title:Association between novel GM-CSF gene polymorphisms and the frequency and severity of atopic dermatitis.|Association:Not Found|Conclusion:The GM-CSF genotype is an important genetic marker predicting an individual's predisposition to atopic dermatitis. | Human | STAT3 | 6774 | signal transducer and activator of transcription 3 (acute-phase response factor) | | Human | ST2 | 6761 | suppression of tumorigenicity 2 | Title:|Association:Y|Conclusion:Not Found | Human | SELP | 6403 | selectin P (granule membrane protein 140kDa, antigen CD62) | | Human | KLK7 | 5650 | kallikrein-related peptidase 7 | Title:Genetic association between an AACC insertion in the 3'UTR of the stratum corneum chymotryptic enzyme gene and atopic dermatitis.|Association:Y|Conclusion:These findings suggest that SCCE could have an important role in the development of atopic dermatitis. KLK7 insertion appears to confer no risk of eczema; no interaction between the SPINK5 risk allele or the putative KLK7 risk allele and FLG mutations was found | Human | NCF2 | 4688 | neutrophil cytosolic factor 2 | | Human | IL5 | 3567 | interleukin 5 (colony-stimulating factor, eosinophil) | Title:Heterogeneity of interleukin 5 genetic background in atopic dermatitis patients: significantdifference between those with blood eosinophilia and normal eosinophil levels.|Association:Not Found|Conclusion:These results suggest that the IL5 gene may play a role in blood eosinophilia associated with atopic dermatitis. We also considered that the IL5 -703C/T gene polymorphism does not have a direct relationship to disease specificity. | Human | IL4R | 3566 | interleukin 4 receptor | Title:An interaction between the IL-4Ralpha gene and infection is associated with atopic eczema in young children.|Association:Y|Conclusion:There is an association between the R551 polymorphism and flexural eczema in children at 6 months of age who have not had infection requiring treatment with antibiotics. Restriction of the R551 association with eczema to children who have not had antibiotics lends support to the 'hygiene hypothesis', which states that exposure to infection in childhood can protect against allergic disease. | Human | FLG | 2312 | filaggrin | FLG mutations are strong genetic determinants of eczema, early wheeze, asthma in the context of eczema, and atopic sensitization Filaggrin gene mutations are associated with asthma and eczema in later life Filaggrin plays a key role in epidermal barrier function, and its association with atopic eczema emphasizes the importance of barrier dysfunction in eczema pathogenesis Eczema (perifollicular accentuation) FLG mutations are associated not only with eczema-associated asthma susceptibility but also with asthma severity independent of eczema status filaggrin mutations are key organ specific factors predominantly affecting the development of eczema and confer significant risks of allergic sensitization and allergic rhinitis as well as asthma in the context of eczema FLG-deficient individuals may need to avoid cats but not dogs in early life to prevent from eczema onset Frequent asthma, eczema or hay fever Two common filaggrin (FLG) null mutations cause ichthyosis vulgaris and predispose to eczema and secondary allergic diseases | Human | MS4A2 | 2206 | membrane-spanning 4-domains, subfamily A, member 2 | | Human | EDA | 1896 | ectodysplasin A | | Human | DHCR7 | 1717 | 7-dehydrocholesterol reductase | | Human | CYBB | 1536 | cytochrome b-245, beta polypeptide | |
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