Genes (30)
Species: human : 30 | |
Human | SUMO4 | 387082 | small ubiquitin-like modifier 4 | data indicate that the M55V polymorphism in the small ubiquitin-like protein 4(SUMO4) gene is associated with a reduced risk of diabetic retinopathy in type 1 diabetes | Human | AKR1B10 | 57016 | aldo-keto reductase family 1, member B10 (aldose reductase) | Z-2 allele of the aldose reductase gene is a risk factor for the development of diabetic retinopathy in a group of Caucasian participants with Type 2 diabetes | Human | ADIPOQ | 9370 | adiponectin, C1Q and collagen domain containing | adiponectin may take part in the pathogenesis of diabetic retinopathy | Human | B4GALT2 | 8704 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 | Significance of core 2 GlcNAc-T in the pathogenesis of capillary occlusion in diabetic retinopathy | Human | VEGFA | 7422 | vascular endothelial growth factor A | VEGF may play a critical role in the development and progression of diabetic retinopathy Title:A common polymorphism in the 5'-untranslated region of the VEGF gene is associated with diabetic retinopathy in type 2 diabetes.|Association:Y|Conclusion:These data suggest that the C(-634)G polymorphism in the 5'UTR of the VEGF gene is a novel genetic risk factor for diabetic retinopathy. C(-634)G genotype was found to increase the risk for diabetic retinopathy in patients with microalbuminuria The D allele of the VEGF polymorphism is an independent risk factor of diabetic retinopathy after controlling for other clinical variables There is a relationship between VEGF, TNF-alpha, IL-6 and the development of the diabetic retinopathy in children with diabetes mellitus type 1 VEGF C-634G polymorphism is a genetic risk factor for macular edema as well as diabetic retinopathy Glial cell-derived cytokines such as GDNF and VEGF regulate the blood retinal barrier, implying that glial cell can be a possible therapeutic target in diabetic retinopathy Study strongly supports previous reports that showed the role of VEGF, macrophages, and AGEs in the development of diabetic proliferative retinopathy bone morphogenetic protein 4 may play a role in the regulation of ocular angiogenesis associated with diabetic retinopathy (DR) by stimulating VEGF release from retinal pigment epithelial cells VEGF, Ets-1, and ERK1 act synergistically in the development of diabetic retinopathy A clear association was demonstrated between VEGF SNPs and severity of diabetic retinopathy Polymorphisms in the 5' UTR and promoter region of VEGF could be regarded as a major genetic risk factor for diabetic retinopathy | Human | VDR | 7421 | vitamin D (1,25- dihydroxyvitamin D3) receptor | polymorphism and risk of severe diabetic retinopathy we observed, in a cohort of Caucasians with C-peptide-negative type 1 diabetes, a novel association between the functional FokI VDR polymorphism and severe diabetic retinopathy | Human | VCAM1 | 7412 | vascular cell adhesion molecule 1 | Direct implication of adhesion molecules in the pathogenesis or progression of type 2 diabetic retinopathy cannot be supported | Human | TNF | 7124 | tumor necrosis factor | Variants among promoter of TNF-alpha are unlikely to play major role in susceptibility to diabetic retinopathy in Chinese patients with type 2 diabetes role of TNF-alpha in the development of diabetic retinopathy | Human | TIMP3 | 7078 | TIMP metallopeptidase inhibitor 3 | TIMP3 is uniquely regulated by Oxidised, glycated LDL lipoproteins, which may contribute to microvascular abnormalities in diabetic retinopathy | Human | SST | 6750 | somatostatin | Possible role of the lower production of SST in the pathogenesis of diabetic retinopathy | Human | SOD2 | 6648 | superoxide dismutase 2, mitochondrial | concludes that the VV genotype of the V16A polymorphism of the manganese superoxide dismutase(Mn-SOD) gene was associated with diabetic retinopathy in Caucasians with type 2 diabetes | Human | PPARG | 5468 | peroxisome proliferator-activated receptor gamma | alanine variant of the Pro12Ala polymorphism of PPARgamma might be associated with decreased risk of diabetic retinopathy in type 2 diabetes Pro12Ala polymorphism of PPAR(gamma2) gene is not associated with diabetic retinopathy but is associated with dyslipidemia in male type 2 diabetic patients | Human | SERPINF1 | 5176 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 | These results demonstrate that the PEDF gene, in cooperation with the VEGF gene, may contribute to the development of diabetic retinopathy The levels of plasma PEDF increases with advances in both diabetic retinopathy and nephropathy PEDF may play a protective role against early diabetic retinopathy by attenuating the deleterious effect of AGE High levels of PEDF in the plasma may be related to the progression of diabetic retinopathy | Human | SERPINE1 | 5054 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | Patients homozygous for allele 4G had a significantly higher risk of diabetic proliferative retinopathy than patients without signs of diabetic retinopathy or nonproliferative retinopathy | Human | NOS3 | 4846 | nitric oxide synthase 3 (endothelial cell) | ecNOS 4 a/b polymorphism does not interact with the development of early carotid arteriosclerosis in young type-1 diabetic patients, but in these patients it could influence the occurence of diabetic retinopathy Significant association between the deletion/insertion polymorphism of the eNOS and diabetic retinopathy in our West African cohort | Human | MTHFR | 4524 | methylenetetrahydrofolate reductase (NAD(P)H) | MTHFR gene C677T mutation associated with a predisposition to increase of plasma homocysteine may represent a genetic risk factor for diabetic retinopathy in Chinese type 2 diabetes mellitus No association between the MTHFR gene polymorphism and diabetic retinopathy in type 2 diabetic patients without overt nephropathy | Human | ITGA2 | 3673 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | genetic variation of platelet glycoprotein Ia may play a particularly important role during the advanced stages of diabetic retinopathy Title:|Association:Y|Conclusion:Not Found | Human | IGF1 | 3479 | insulin-like growth factor 1 (somatomedin C) | 18-repeat genotype is a susceptibility genotype for diabetic retinopathy and its clinical severity in a Southern Indian cohort findings suggest that this insulin-like growth factor 1(IGF-I) gene polymorphism is associated with an increased risk of diabetic retinopathy | Human | ICAM1 | 3383 | intercellular adhesion molecule 1 | polymorphism is associated with diabetic retinopathy in type 2 diabetes mellitus | Human | TNC | 3371 | tenascin C | differences in protein levels found in the vitreous body of patients with diabetic retinopathy | Human | HP | 3240 | haptoglobin | no significant differences were observed for the three Hp genotypes; this polymorphism is not associated with the presence of diabetic retinopathy in the Brazilian population | Human | FABP2 | 2169 | fatty acid binding protein 2, intestinal | fatty acid binding protein 2 polymorphism Ala54Thr is not associated with diabetic retinopathy | Human | ENG | 2022 | endoglin | CD105 levels could serve as a surrogate marker for early stage diabetic retinopathy and for monitoring disease progression | Human | EDN1 | 1906 | endothelin 1 | The Asn/Asn genotype of EDN1 was associated with a reduced risk of diabetic retinopathy and with delayed onset of type 2 diabetes | Human | ACE | 1636 | angiotensin I converting enzyme | Title:Detection of the association between a deletion polymorphism in the gene encoding angiotensin I-converting enzyme and advanced diabetic retinopathy.|Association:Not Found|Conclusion:Not Found |
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