Human | CCR2 | 729230 | chemokine (C-C motif) receptor 2 | Title:Involvement of polymorphisms in the chemokine system in the susceptibility for coronary artery disease (CAD). Coincidence of elevated Lp(a) and MCP-1 -2518 G/G genotype in CAD patients.|Association:Y|Conclusion:The MCP-1 -2518G variant in homozygous form appears as a genetic risk factor for severe CAD. This genotype is associated with elevated Lp(a) levels in patients. Individuals homozygous for CCR2-64I or CCR5Delta32 mutations are at reduced risk for severe CAD. |
Human | NCF1C | 654817 | neutrophil cytosolic factor 1C pseudogene | Increased expression and activity of NAD(P)H oxidase subunits and xanthine oxidase, in part mediated through angiotensin II and PKC-dependent pathways, are important mechanisms underlying increased oxidative stress in human coronary artery disease |
Human | IFNE | 338376 | interferon, epsilon | A meta-analysis and a single-nucleotide polymorphism (SNP) rs1333049 representing the 9p21.3 locus provide unprecedented evidence for association between genetic variants at chromosome 9p21.3 and risk of coronary artery disease |
Human | UTS2D | 257313 | | These findings suggest that U-II plays key roles in accelerating the development of atherosclerosis, thereby leading to coronary artery disease |
Human | PCSK9 | 255738 | proprotein convertase subtilisin/kexin type 9 | nonsense mutations in PCSK9 were associated with a reduction in mean LDL cholesterol and a reduction in the risk of coronary heart disease |
Human | KIF6 | 221458 | kinesin family member 6 | The KIF6 719Arg variant has been associated with an increased risk of coronary disease and an increased response to statin therapy |
Human | CAQ14 | 171512 | Circulating adiponectin QTL on chromosome 14 | Male patients with hypoadiponectinemia (<4.0 microg/mL) have a significant 2-fold increase in coronary artery disease (CAD) prevalence, independent of well-known CAD risk factors |
Human | APOA5 | 116519 | apolipoprotein A-V | Click here to display 5 evidence detail records. |
Human | CNDP1 | 84735 | carnosine dipeptidase 1 (metallopeptidase M20 family) | no difference in allele or genotype frequency between centenarians & controls or between cardiovascular patients & controls; the recently identified functional carnosinase variant does not contribute to longevity or protect against coronary heart disease |
Human | VKORC1 | 79001 | vitamin K epoxide reductase complex, subunit 1 | study examined the potential association between the functional SNP rs9923231 & early-onset coronary heart disease (CHD)in Northern Germans; no evidence for a significant association was detected between VKORC1 genotype & CHD phenotype |
Human | P2RY12 | 64805 | purinergic receptor P2Y, G-protein coupled, 12 | Gene sequence variations of the P2Y12 receptor gene are associated with the presence of significant coronary artery disease, particularly in non-smoking individuals There is no association between P2Y12 receptor gene polymorphism and platelet response to clopidogrel in patients with coronary artery disease |
Human | XYLT2 | 64132 | xylosyltransferase II | INFERRED, Score=800, UMLKSK CUI: C0010068 |
Human | XYLT1 | 64131 | xylosyltransferase I | INFERRED, Score=800, UMLKSK CUI: C0010068 |
Human | RETN | 56729 | resistin | there was a strong correlation of resistin levels with inflammatory markers suggesting resistin as an inflammatory marker associated with coronary artery disease Serum resistin may prove to be a useful biological marker for coronary artery disease and restenosis in patients with type 2 diabetes mellitus |
Human | SLC2A9 | 56606 | solute carrier family 2 (facilitated glucose transporter), member 9 | common genetic variations within the GLUT9 gene strongly influence the risk for gout but are unlikely to have a major effect on coronary artery disease or myocardial infarct in a German population |
Human | APOM | 55937 | apolipoprotein M | The apoM gene is a risk factor for genetic susceptibility to coronary artery disease and is also associated with total cholesterol levels in Han Chinese results of the present study suggest that the APOM T-855C polymorphism carries an increased risk for coronary artery disease in this Chinese population |
Human | PARL | 55486 | presenilin associated, rhomboid-like | the PARL rs3732581 genetic variant may have a role in insulin levels, metabolic syndrome and coronary artery disease |
Human | UGT1A1 | 54658 | UDP glucuronosyltransferase 1 family, polypeptide A1 | Although the concentration of bilirubin in the UGT1A1 variant is higher than the wild type for the patients with coronary disease (CAD), there is no significant difference in the polymorphism between the patients and the participants in the control group |
Human | GHRL | 51738 | ghrelin/obestatin prepropeptide | data indicate that the preproghrelin Leu72Met polymorphism is not associated with coronary artery disease (CAD) in Chinese population; however, the Leu72Met variant is associated with BMI among CAD patients |
Human | GP6 | 51206 | glycoprotein VI (platelet) | genotyped 2090 women in Heart and Estrogen/progestin Replacement Study for functional polymorphisms in GP1BA and GP6 and assessed the coronary heart disease |
Human | INSIG2 | 51141 | insulin induced gene 2 | The INSIG1 gene, not the INSIG2 gene, associated with coronary heart disease: tagSNPs and haplotype-based association study |
Human | ADIPOR1 | 51094 | adiponectin receptor 1 | Our findings point to genetic variability at the ADIPOR1 locus as a strong determinant of coronary artery disease susceptibility in type 2 diabetes |
Human | BHMT2 | 23743 | betaine--homocysteine S-methyltransferase 2 | Hyperhomocysteinemia, a risk factor for coronary diseases, can be caused by genetic mutations in BHMT2 metabolism |
Human | C7orf16 | 10842 | | INFERRED, Score=800, UMLKSK CUI: C0010068 |
Human | DHS | 10774 | dehydrated hereditary stomatocytosis | INFERRED, Score=800, UMLKSK CUI: C0010068 |