Human | APH1B | 83464 | APH1B gamma secretase subunit | A non-synonymous SNP in the gamma-secretase component APH1B (Phe217Leu; rs1047552)is significantly associated with premature coronary atherosclerosis in Dutch males |
Human | ABCG8 | 64241 | ATP-binding cassette, sub-family G (WHITE), member 8 | |
Human | ABCG5 | 64240 | ATP-binding cassette, sub-family G (WHITE), member 5 | |
Human | ADIPOQ | 9370 | adiponectin, C1Q and collagen domain containing | The -11377 C > G adiponectin gene promoter variant is i) associated with decreased serum adiponectin levels, ii) correlated with the presence of coronary atherosclerosis and iii) significantly predictive of vascular events among men Adiponectin might play a protective role in coronary atherosclerosis progression in patients with chest pain |
Human | TNF | 7124 | tumor necrosis factor | Concentrations of adhesion molecules and TNF-alpha are associated with coronary atherosclerosis in SLE independent of the Framingham risk score CD14 and CD16 in monocytes may have a role in development of coronary atherosclerosis and expression of TNF-alpha |
Human | SOD1 | 6647 | superoxide dismutase 1, soluble | heparin-released EC-SOD is significantly reduced in coronary artery atherosclerosis |
Human | CCL2 | 6347 | chemokine (C-C motif) ligand 2 | the MCP-1 gene -2578A>G polymorphism is associated with an excess risk of coronary atherosclerosis in an asymptomatic population and is a risk factor |
Human | PON1 | 5444 | paraoxonase 1 | Amino Acid Substitution in paraoxonase-1 is associated with alcohol consumption and coronary atherosclerosis |
Human | PEPD | 5184 | peptidase D | serum prolidase activity is significantly associated with the presence and severity of coronary artery disease, and elevated serum prolidase activity might be an independent predictor of coronary atherosclerosis |
Human | SERPINE1 | 5054 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | Title:The 4G4G genotype of the plasminogen activator inhibitor 4G/5G gene polymorphism is associated with coronary atherosclerosis in patients at high risk for this disease.|Association:Y|Conclusion:The present data indicate that the 4G/4G genotype of the PAI-I gene polymorphism is an independent risk factor for coronary artery disease and that the additional presence of major cardiovascular risk factors accelerates the risk for this disease. |
Human | NPY | 4852 | neuropeptide Y | NPY Pro7 substitution protects middle-aged men from coronary artery atherosclerosis and might decrease the risk of acute coronary events |
Human | NOS3 | 4846 | nitric oxide synthase 3 (endothelial cell) | This gene 4a/b polymorphism was not associated with the extent of coronary arteriosclerosis, but the a-allele of the variant seems to protect to some degree against the development of myocardial infarction Title:The G894T mutation of the endothelial nitric oxide synthase gene is associated with coronary atherosclerotic heart disease in Chinese|Association:Y|Conclusion:The G894T mutation of the endothelial nitric oxide synthase gene may be a marker for genetical predisposition of CHD in Chinese Han population. |
Human | NGF | 4803 | nerve growth factor (beta polypeptide) | Results support the involvement of NGF, BDNF, leptin, and mast cells in human coronary atherosclerosis and metabolic syndrome, implying neuroimmune and adipoimmune pathways in the pathobiology of these cardiovascular disorders |
Human | MTHFR | 4524 | methylenetetrahydrofolate reductase (NAD(P)H) | severity of CAD and is related to the MTHFR polymorphism, suggesting an interesting link between coronary atherosclerosis and genetic instability in humans The interaction between MTHFR 677 C-->T genotype and folate status is a determinant of coronary atherosclerosis risk |
Human | MPO | 4353 | myeloperoxidase | The mechanisms by which MPO impacts the arterial wall in coronary arteriosclerosis, especially lipoprotein metabolism |
Human | LTA | 4049 | lymphotoxin alpha | Evidence of an association between lymphotoxin alpha genotype and the extent of coronary atherosclerosis is provided |
Human | LPL | 4023 | lipoprotein lipase | Single Nucleotide Polymorphisms in Lipoprotein Lipase gene is associated with variation in plasma triglyceride levels Coronary Arteriosclerosis |
Human | LGALS2 | 3957 | lectin, galactoside-binding, soluble, 2 | polymorphism of LGALS2 was not associated with the severity of coronary atherosclerosis in Japanese and Korean populations |
Human | LCAT | 3931 | lecithin-cholesterol acyltransferase | 608T polymorphism of LCAT gene was associated with higher plasma HDL-C level in Coronary Arteriosclerosis patients |
Human | ITGB3 | 3690 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | Title:The GPIIIa (beta(3) integrin) Pl(A) polymorphism in the early development of coronary atherosclerosis|Association:Not Found|Conclusion:The findings of this study suggest that Pl(A1/A1) homozygotes may be prone to early atherosclerosis and more rapid progression of stable CAD whereas carriers of the Pl(A2) allele are more prone to thrombotic complications. |
Human | IL18 | 3606 | interleukin 18 (interferon-gamma-inducing factor) | Plasma IL-18 is increased in postinfarction patients and is associated with coronary atherosclerosis |
Human | IL10 | 3586 | interleukin 10 | IL-10 concentration was associated with an increased risk for future cardiovascular events in post-menopausal women with established coronary atherosclerosis |
Human | IL1RN | 3557 | interleukin 1 receptor antagonist | Title:|Association:Y|Conclusion:Not Found |
Human | HSPB1 | 3315 | heat shock 27kDa protein 1 | HSP27, an ERbeta-associated protein, shows attenuated expression with coronary atherosclerosis and modulates estrogen signaling |
Human | HMOX1 | 3162 | heme oxygenase (decycling) 1 | the capacity to upregulate HO-1 expression may be determined, at least in part, by genetics, and reduced ability to induce HO-1 may be involved in the mechanism of coronary atherosclerosis |