Mouse | TAGLN | 6876 | transgelin | The reduction of transgelin expression in mouse colon tumors was confirmed by Western blotting and immunohistochemistry. |
Mouse | PTK2 | 5747 | protein tyrosine kinase 2 | Additionally, treatment of mice with multiple Src inhibitors resulted in inhibition of phosphorylation of FAK (Y861) and of a putative Src autophosphorylation epitope (Y419) in HT-29 human colon tumor xenografts. |
Mouse | HPGD | 3248 | hydroxyprostaglandin dehydrogenase 15-(NAD) | We first show that 15-PGDH gene knockout induces a marked 7.6-fold increase in colon tumors arising in the Min (multiple intestinal neoplasia) mouse model. Furthermore, 15-PGDH gene knockout abrogates the normal resistance of C57BL/6J mice to colon tumor induction by the carcinogen azoxymethane (AOM), conferring susceptibility to AOM-induced adenomas and carcinomas in situ. |
Mouse | CYP26A1 | 1592 | cytochrome P450, family 26, subfamily A, polypeptide 1 | Up-regulation of CYP26A1 in Adenomatous Polyposis Coli-Deficient Vertebrates via a WNT-Dependent Mechanism: Implications for Intestinal Cell Differentiation and Colon Tumor Development. |
Mouse | CCKBR | 887 | cholecystokinin B receptor | Inhibition of pentagastrin-stimulated up-regulation of gastrin receptors and growth of mouse colon tumor in vivo by proglumide, a gastrin receptor antagonist. |
Mouse | CEACAM1 | 634 | carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) | Click here to display 5 evidence detail records. |
Human | MUC5B | 727897 | mucin 5B, oligomeric mucus/gel-forming | The moderately differentiated human colon tumor cell line, HT-29, constitutively expresses low levels of the high molecular weight mucin, tumor-associated glycoprotein 72 (TAG-72), and the M(r) 180,000 carcinoembryonic antigen (CEA) when grown as s.c. tumors in athymic mice. |
Human | BCL2L15 | 440603 | BCL2-like 15 | In the transition from normal tissue to tumour, pro-apoptotic Bfk isoform expression is substantially reduced in up to 80% of tumours isolated from the human gastrointestinal tract (8/10 colonic tumours and 26/37 of all gastrointestinal tumours) compared to 3/117 tumours from outside the gastrointestinal tract. |
Human | AGRN | 375790 | agrin | INFERRED, Score=800, UMLKSK CUI: C0009375 |
Human | ENPP7 | 339221 | ectonucleotide pyrophosphatase/phosphodiesterase 7 | INFERRED, Score=800, UMLKSK CUI: C0009375 |
Human | PAOX | 196743 | polyamine oxidase (exo-N4-amino) | The results of these experiments demonstrated for the first time that: (i) MDL 72527 was a specific inhibitor of polyamine oxidase in normal and malignant colonic tissue; (ii) concomitant administration of this agent with DMH enhanced the elevation of colonic N1-acetylspermidine and significantly reduced the mean colonic tumor burden, as assessed by total tumor area per rat, produced by this carcinogen alone; (iii) analysis of K-ras mutations revealed a similar incidence (62-69%) in adenocarcinomas for both groups (+/- MDL 72527); (iv) however, analysis of the K-ras-mutated and non-mutated tumors revealed that in both carcinogen-treated groups (+/- MDL 72527), tumors with such mutations were smaller than their counterparts without such genetic alterations. |
Human | NEWENTRY | 192343 | Record to support submission of GeneRIFs for a gene not in Gene (human; man). | The switching of linoleic acid metabolism by reversal of the expression of 15LOX-1 and COX-2 is associated with acquisition of malignant potential in colonic neoplasia [15LOX-1] |
Human | CLDN23 | 137075 | claudin 23 | Human CLDN23 mRNA was expressed in germinal center B cells, placenta, stomach as well as in colon tumor. |
Human | MINA | 84864 | MYC induced nuclear antigen | We generated a specific monoclonal anti-human Mina53 antibody and found that colon tumor cell lines expressed Mina53 highly. We also found that expression of Mina53 was elevated in colon tumor tissues by immunoblotting analysis. Suppression of mina53 expression severely suppressed proliferation of colon tumor cells in vitro. |
Human | TUBA1C | 84790 | tubulin, alpha 1c | INFERRED, Score=800, UMLKSK CUI: C0009375 |
Human | ANTXR1 | 84168 | anthrax toxin receptor 1 | TEM-8 identified more micro-vessels in colon tumour tissue, than in normal colon tissues, (p=0.002). |
Human | TNKS2 | 80351 | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 | TNKL and TNKS are aberrantly expressed in colon tumors and contain multiple epitopes that induce humoral and cellular immune responses in cancer patients |
Human | CDCP1 | 64866 | CUB domain containing protein 1 | In colon tumor, SIMA135/CDCP1 expression appeared dysregulated showing extensive cell surface as well as cytoplasmic expression. CDCP1 mRNA is highly expressed in lung and colon tumors and in the erythroleukemic cell line K562. |
Human | RHOU | 58480 | ras homolog family member U | On the other hand, WRCH1 mRNA was significantly down-regulated in 6 cases of colon tumors, 2 cases of primary kidney cancer and breast cancer. |
Human | MUC3B | 57876 | mucin 3B, cell surface associated | Both the MUC2 and MUC3 mucins are expressed in colonic tumors; however, the level of their expression is quite variable. We examined the steady-state expression levels of mRNA for the MUC1, MUC2, MUC3 and MUC4 gene products in 12 pancreatic tumor cell lines, 6 colon tumor cell lines, and one ileocecal tumor cell line. |
Human | S100A14 | 57402 | S100 calcium binding protein A14 | We also provide evidence for heterogenic expression of S100A14 in tumors, demonstrating its overexpression in ovary, breast, and uterus tumors and underexpression in kidney, rectum, and colon tumors, a pattern suggesting distinct regulation with potentially important functions in malignant transformation. |
Human | CTNNBIP1 | 56998 | catenin, beta interacting protein 1 | INFERRED, Score=800, UMLKSK CUI: C0009375 |
Human | CHFR | 55743 | checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase | In the present study, we report that Chfr is frequently methylated in cell lines derived from tumors of the colon (80%), brain (100%) and bone (100%). |
Human | FERMT1 | 55612 | fermitin family member 1 | Quantification of URP1 expression by qRT-PCR showed up-regulation of the gene by 60-fold in lung tumors and up to nearly 6-fold in colon tumors. |
Human | GIPC2 | 54810 | GIPC PDZ domain containing family, member 2 | Expression of GIPC2 mRNA was significantly down-regulated in 6 out of 14 cases of primary kidney tumors, in 5 out of 11 cases of primary colon tumors, and in 1 out of 7 cases of primary rectal tumors. |