Genes (366)
Species: human : 363 mouse : 3 | |
Mouse | EBAG9 | 9166 | estrogen receptor binding site associated, antigen, 9 | Here we show that intratumoral (i.t.) administration of small interfering RNA against EBAG9 exerted overt regression of tumors following s.c. implantation of murine renal cell carcinoma (RCC) Renca cells. | Mouse | TIMP2 | 7077 | TIMP metallopeptidase inhibitor 2 | To clarify the significance of the balance between matrix metalloproteinase-2 (MMP-2) and tissue inhibitor of metalloproteinase-2 (TIMP-2) in the progression of renal cell carcinoma, we transfected both the MMP-2 and TIMP-2 genes simultaneously into RenCa, a mouse renal cell carcinoma cell line that does not express detectable levels of either MMP-2 or TIMP-2 mRNAs, and established several clones with various MMP-2:TIMP-2 expression ratios. Relative expression of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 in mouse renal cell carcinoma cells regulates their metastatic potential. | Mouse | FGF8 | 2253 | fibroblast growth factor 8 (androgen-induced) | We detected FGF-8 mRNA expression in murine cell lines of bladder and renal cell carcinomas but not in those of the normal bladder and kidney. | Human | DIRC3 | 729582 | disrupted in renal carcinoma 3 | Disruption of a novel gene, DIRC3, and expression of DIRC3-HSPBAP1 fusion transcripts in a case of familial renal cell cancer and t(2;3)(q35;q21). | Human | GGT2 | 728441 | gamma-glutamyltransferase 2 | Click here to display 5 evidence detail records. | Human | MAGED4 | 728239 | melanoma antigen family D, 4 | Ligands from MAGED4 could thus be interesting tumor-associated antigens in a subset of RCC, even though the identified ligand is presented by a rather rare allele. MAGED4 was expressed in 30% of RCC and both glioblastoma samples. We analyzed the expression of 21 MAGE genes in ten RCC samples and two glioblastoma samples and could identify the first MHC class I ligand NIGDEALIGRW from MAGED4 presented by HLA-A*25 on RCC solid tumor tissue. MAGED4-expression in renal cell carcinoma and identification of an HLA-A*25-restricted MHC class I ligand from solid tumor tissue. | Human | ERVK7 | 449619 | | DNA methylation and expression of LINE-1 and HERV-K provirus sequences in urothelial and renal cell carcinomas. | Human | LOC442459 | 442459 | | The association between DNA repair gene polymorphism and the genetic susceptibility and progression of renal cell carcinoma are not specific | Human | LAMA1 | 284217 | laminin, alpha 1 | Laminin alpha1 chain in human renal cell carcinomas and integrin-mediated adhesion of renal cell carcinoma cells to human laminin isoforms. | Human | MAGEA2B | 266740 | melanoma antigen family A, 2B | To develop T-cell-based immunotherapeutic approaches for renal cell carcinoma (RCC), we studied the mRNA expression profile of the TAAs RAGE-1, tyrosinase, MAGE-1, MAGE-2, NY-ESO-1, Melan-A/MART-1, glycoprotein (gp) 75, gp100, beta-catenin, PRAME, and MUM-1 in 14 human RCC cell lines and in tissue specimens of 37 primary RCCs, 2 related metastases, and 33 specimens of normal renal epithelium. | Human | HEPACAM | 220296 | hepatic and glial cell adhesion molecule | Predisposition to renal cell carcinoma due to alteration of a cancer susceptibility gene. | Human | FLCN | 201163 | folliculin | Associated endometrial carcinoma, atypical endometrial hyperplasia, uterine leiomyosarcoma, bladder transitional carcinoma, gastric, biliary and renal cell carcinoma | Human | SYT6 | 148281 | synaptotagmin VI | SYT6 is hypermethylated in renal cell carcinoma | Human | FAM129A | 116496 | family with sequence similarity 129, member A | In addition, Niban was also expressed in other renal carcinoma models, including Tsc1 and Tsc2 knockout mice, and various types of human renal cell carcinomas. | Human | MUC16 | 94025 | mucin 16, cell surface associated | A correlation has been found between CA125 expression and prognosis in renal cell carcinoma patients who underwent nephrectomy | Human | MUM1 | 84939 | melanoma associated antigen (mutated) 1 | Transcription of tyrosinase, Melan-A/MART-1, MAGE-1, MAGE-2, NY-ESO-1, gp100, beta-catenin, and MUM-1 was not detected in any RCC cell line. To develop T-cell-based immunotherapeutic approaches for renal cell carcinoma (RCC), we studied the mRNA expression profile of the TAAs RAGE-1, tyrosinase, MAGE-1, MAGE-2, NY-ESO-1, Melan-A/MART-1, glycoprotein (gp) 75, gp100, beta-catenin, PRAME, and MUM-1 in 14 human RCC cell lines and in tissue specimens of 37 primary RCCs, 2 related metastases, and 33 specimens of normal renal epithelium. One RCC specimen expressed MAGE-2, whereas transcription was not detected in any RCC specimen for MAGE-1, NY-ESO-1, tyrosinase, Melan-A/MART-1, gp100, beta-catenin, and MUM-1. | Human | DIRC2 | 84925 | disrupted in renal carcinoma 2 | | Human | MINA | 84864 | MYC induced nuclear antigen | Mina53 is overexpressed in renal cell carcinoma tissue from patients with poor prognostic factors, suggesting that Mina53 overexpression is one of the factors for poor prognosis in renal cell carcinoma | Human | C19orf48 | 84798 | chromosome 19 open reading frame 48 | Donor T-cell responses against the HLA-A*0201-restricted minor H antigen encoded by C19orf48 may contribute to renal cell carcinoma regression after MHC-matched allogeneic hematopoietic cell transplantation | Human | MAGED4B | 81557 | melanoma antigen family D, 4B | To develop T-cell-based immunotherapeutic approaches for renal cell carcinoma (RCC), we studied the mRNA expression profile of the TAAs RAGE-1, tyrosinase, MAGE-1, MAGE-2, NY-ESO-1, Melan-A/MART-1, glycoprotein (gp) 75, gp100, beta-catenin, PRAME, and MUM-1 in 14 human RCC cell lines and in tissue specimens of 37 primary RCCs, 2 related metastases, and 33 specimens of normal renal epithelium. | Human | KCNIP4 | 80333 | Kv channel interacting protein 4 | Mutation of KCNIP4 is associated with renal cell carcinoma | Human | AGMAT | 79814 | agmatine ureohydrolase (agmatinase) | Human agmatinase is diminished in the clear cell type of renal cell carcinoma. Agmatinase is down-regulated in the clear cell type of renal cell carcinoma | Human | VTCN1 | 79679 | V-set domain containing T cell activation inhibitor 1 | patients with renal cell carcinoma (RCC) tumors expressing both B7-H4 and B7-H1 are at an even greater risk of death from RCC renal cell carcinoma patients are more likely to have detectable sB7x compared with controls and higher sB7x levels correlate with advanced tumor stage | Human | CDC73 | 79577 | cell division cycle 73 | Papillary renal cell carcinoma | Human | BIRC7 | 79444 | baculoviral IAP repeat containing 7 | Increased livin protein expression is associated with renal cell carcinoma Livin expression is detected in 59 (38.8%) of 152 renal cell carcinoma specimens but not any in normal samples |
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