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Details
Link-It Detail - Disease - Carcinoma, Renal Cell
Debug Stats
  • ### Total Build Time: 152 ms 64.544 KB
  • CONCEPT_NAME gt=5 ms Completed: 5 ms rowSize= 390 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 835 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 187 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=7 ms Completed: 7 ms rowSize= 984 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=6 ms Completed: 6 ms rowSize= 6.609 KB
  • CONCEPT_RELATIONSHIPS gt=75 ms Completed: 75 ms rowSize= 16.840 KB
  • CONCEPT_GENES gt=58 ms Completed: 58 ms rowSize= 37.564 KB
  • CONCEPT_XREFS gt=1 ms Completed: 1 ms rowSize= 1.155 KB
  • CONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes
  • Reload Stats
Disease (2)
Carcinoma, Renal Cell C0007134
Renal Cell Carcinoma
Definition (1)
A carcinoma arising from the renal parenchyma. The incidence of renal cell carcinoma has increased by 35% from 1973 to 1991. There is a strong correlation between cigarette smoking and the development of renal cell carcinoma. The clinical presentation includes : hematuria, flank pain and a palpable lumbar mass. A high percentage of renal cell carcinomas are diagnosed when an ultrasound is performed for other purposes. Diagnostic procedures include: ultra sound, intravenous pyelography and computed tomography (CT). Radical nephrectomy is the standard intervention procedure. Renal cell carcinoma is generally considered to be resistant to radiation treatment and chemotherapy.
Semantic Types (1)
Neoplastic Process (T191)
Parents (2)
img Kidney Neoplasms C0022665
img Adenocarcinoma C0001418
Ancestral Roots
RootRoot Plus OneDepthParent
img Female Urogenital Diseases and Pregnancy Complications C1720765img Female Urogenital Diseases C17208876img Kidney Neoplasms C0022665
img Male Urogenital Diseases C1720894img Urogenital Neoplasms C00420655img Kidney Neoplasms C0022665
img Neoplasms C0027651img Neoplasms by Site C00276536img Kidney Neoplasms C0022665
img Male Urogenital Diseases C1720894img Urologic Diseases C00420755img Kidney Neoplasms C0022665
img Neoplasms C0027651img Neoplasms by Histologic Type C00276526img Adenocarcinoma C0001418
Relationships (299)

Relation Types:
diso_​to_​anat : 41
diso_​to_​chem : 124
diso_​to_​diso : 112
diso_​to_​gene : 8
diso_​to_​phen : 2
diso_​to_​phys : 12


Relationships:
none : 186
associated_​with : 1
clinically_​similar : 7
gene_​associated_​with_​disease : 6
is_​abnormal_​cell_​of_​disease : 6
is_​associated_​anatomic_​site_​of : 3
is_​finding_​of_​disease : 2
is_​normal_​cell_​origin_​of_​disease : 2
is_​normal_​tissue_​origin_​of_​disease : 2
is_​not_​abnormal_​cell_​of_​disease : 4
is_​not_​finding_​of_​disease : 1
is_​primary_​anatomic_​site_​of_​disease : 1
isa : 13
mapped_​to : 5
may_​be_​finding_​of_​disease : 2
may_​treat : 57
permuted_​term_​of : 1
Page Size
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Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_DISO5707img Kidney Neoplasm C0022665
DISO_to_DISO3443img Kidney Neoplasm C0022665
DISO_to_PHEN913img genetic aspects C0017399
DISO_to_CHEM703img Antineoplastic Agents C0003392
DISO_to_PHEN593img genetic aspects C0017399
DISO_to_CHEM349img Indoles C0021242
DISO_to_CHEM347img Pyrroles C0034325
DISO_to_DISO317img Complication Aspects C1171258
DISO_to_CHEM278img BIOCHEM TUMOR MARKERS C0041366
DISO_to_DISO235img Complication Aspects C1171258
DISO_to_CHEM223img Antineoplastic Agents C0003392
DISO_to_CHEM212img Pyridines C0034255
DISO_to_CHEM205img Benzenesulfonates C0005040
DISO_to_CHEM185img ANGIOGENESIS INHIB C0596087
DISO_to_CHEM171img Protein Kinase Inhibitors C1449702
DISO_to_ANAT157img Blood supply aspects C0005839
DISO_to_DISO149img Lung Neoplasms C0024121
DISO_to_ANAT148img In Blood C0005768
DISO_to_DISO129img MULTIPLE PRIMARY NEOPL C0027663
DISO_to_ANAT126img Kidney C0022646
DISO_to_CHEM126img BIOCHEM TUMOR MARKERS C0041366
DISO_to_ANAT121img Inferior vena cava structure C0042458
DISO_to_CHEM120img Interleukin-2 C0021756
DISO_to_CHEM117img Interferon-alpha C0002199
DISO_to_CHEM113img Sirolimus C0072980
Genes (366)

Species:
human : 363
mouse : 3
Page Size
Current 25
  Page 1 of 15
Prior Page
Current 1
SpeciesGeneGeneIdGene NameEvidence
MouseEBAG99166estrogen receptor binding site associated, antigen, 9
img NCI, Score=801, Pubmed Id: 15867365, UMLKSK CUI: C0007134
MouseTIMP27077TIMP metallopeptidase inhibitor 2
img NCI, Score=801, Pubmed Id: 10537348, UMLKSK CUI: C0007134
img NCI, Score=801, Pubmed Id: 10537348, UMLKSK CUI: C0007134
MouseFGF82253fibroblast growth factor 8 (androgen-induced)
img NCI, Score=801, Pubmed Id: 8616814, UMLKSK CUI: C0007134
HumanDIRC3729582disrupted in renal carcinoma 3
img NCI, Score=801, Pubmed Id: 12939738, UMLKSK CUI: C0007134
HumanGGT2728441gamma-glutamyltransferase 2
Click here to display 5 evidence detail records.
HumanMAGED4728239melanoma antigen family D, 4
img NCI, Score=801, Pubmed Id: 16082191, UMLKSK CUI: C0007134
img NCI, Score=801, Pubmed Id: 16082191, UMLKSK CUI: C0007134
img NCI, Score=801, Pubmed Id: 16082191, UMLKSK CUI: C0007134
img NCI, Score=801, Pubmed Id: 16082191, UMLKSK CUI: C0007134
HumanERVK7449619
img NCI, Score=801, Pubmed Id: 10424731, UMLKSK CUI: C0007134
HumanLOC442459442459
img GENERIF, Score=1000, Pubmed Id: 17712032, UMLKSK CUI: C0007134
HumanLAMA1284217laminin, alpha 1
img NCI, Score=801, Pubmed Id: 12754736, UMLKSK CUI: C0007134
HumanMAGEA2B266740melanoma antigen family A, 2B
img NCI, Score=801, Pubmed Id: 9751617, UMLKSK CUI: C0007134
HumanHEPACAM220296hepatic and glial cell adhesion molecule
img NCI, Score=801, Pubmed Id: 1553556, UMLKSK CUI: C0007134
HumanFLCN201163folliculin
img OMIM, Score=1000, UMLKSK CUI: C0007134
img OMIM, Score=1000, UMLKSK CUI: C0007134
HumanSYT6148281synaptotagmin VI
img GENERIF, Score=1000, Pubmed Id: 18639284, UMLKSK CUI: C0007134
HumanFAM129A116496family with sequence similarity 129, member A
img NCI, Score=801, Pubmed Id: 14990989, UMLKSK CUI: C0007134
HumanMUC1694025mucin 16, cell surface associated
img GENERIF, Score=756, Pubmed Id: 12893366, UMLKSK CUI: C0007134
HumanMUM184939melanoma associated antigen (mutated) 1
img NCI, Score=801, Pubmed Id: 9751617, UMLKSK CUI: C0007134
img NCI, Score=801, Pubmed Id: 9751617, UMLKSK CUI: C0007134
img NCI, Score=801, Pubmed Id: 9751617, UMLKSK CUI: C0007134
HumanDIRC284925disrupted in renal carcinoma 2
img OMIM, Score=1000, UMLKSK CUI: C0007134
HumanMINA84864MYC induced nuclear antigen
img GENERIF, Score=1000, Pubmed Id: 17803656, UMLKSK CUI: C0007134
HumanC19orf4884798chromosome 19 open reading frame 48
img GENERIF, Score=756, Pubmed Id: 18698046, UMLKSK CUI: C0007134
HumanMAGED4B81557melanoma antigen family D, 4B
img NCI, Score=801, Pubmed Id: 9751617, UMLKSK CUI: C0007134
HumanKCNIP480333Kv channel interacting protein 4
img GENERIF, Score=1000, Pubmed Id: 17981209, UMLKSK CUI: C0007134
HumanAGMAT79814agmatine ureohydrolase (agmatinase)
img NCI, Score=801, Pubmed Id: 14648699, UMLKSK CUI: C0007134
img GENERIF, Score=1000, Pubmed Id: 14648699, UMLKSK CUI: C0007134
HumanVTCN179679V-set domain containing T cell activation inhibitor 1
img GENERIF, Score=1000, Pubmed Id: 16798883, UMLKSK CUI: C0007134
img GENERIF, Score=756, Pubmed Id: 18676826, UMLKSK CUI: C0007134
HumanCDC7379577cell division cycle 73
img OMIM, Score=1000, UMLKSK CUI: C0007134
HumanBIRC779444baculoviral IAP repeat containing 7
img GENERIF, Score=1000, Pubmed Id: 17968430, UMLKSK CUI: C0007134
img GENERIF, Score=717, Pubmed Id: 17519534, UMLKSK CUI: C0007134
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0007134Carcinoma, Renal Cell0self