Genes (24)
Species: human : 24 | |
Human | GGT2 | 728441 | gamma-glutamyltransferase 2 | These findings merit further exploration to document the extent of the expression of GGT in bronchogenic cancer and to attempt to explain its presence in alveolar cell metaplasia. In contrast to its absence in normal and hyperplastic bronchial mucosa, gamma glutamyl transferase (GGT) has been demonstrated on the luminal surface of adenocarcinoma cells of bronchogenic cancer in three cases studied. | Human | PSORS1C2 | 170680 | psoriasis susceptibility 1 candidate 2 | Expression of spr1 in 63 cases of formalin-fixed and paraffin-embedded human bronchogenic carcinoma was studied by immunohistochemical staining. We conclude that spr1 is a sensitive and specific marker for squamous bronchogenic carcinoma. Loss of spr1 expression measurable by quantitative RT-PCR in human bronchogenic carcinoma cell lines. | Human | TPSB2 | 64499 | tryptase beta 2 (gene/pseudogene) | 1. Mast cell activation in the lung was investigated by measuring concentrations of mast cell tryptase and histamine in the bronchoalveolar lavage fluid from patients with bronchial carcinoma, sarcoidosis, extrinsic allergic alveolitis or cryptogenic fibrosing alveolitis and from normal subjects. | Human | TGFB2 | 7042 | transforming growth factor, beta 2 | The 1PT cell line, derived from an undifferentiated bronchial carcinoma, produced, in conditioned medium, immunoreactive basic fibroblast growth factor (bFGF), insulin-like growth factors I and II (IGF-I and IGF-II), epidermal growth factor (EGF), transforming growth factor alpha (TGF alpha), and transforming growth factor beta-2 (TGF beta 2) in its latent form, but not platelet-derived growth factor (PDGF), tumour necrosis factor alpha (TNF alpha), or transforming growth factor beta-1 (TGF beta 1). | Human | TERC | 7012 | telomerase RNA component | Our studies demonstrate that dysregulation of telomerase occurs early in the multistage pathogenesis of bronchogenic lung carcinomas and that intense focal localized hTR expression in CIS may indicate imminent invasion. | Human | SDC2 | 6383 | syndecan 2 | Perlecan, a matrix-associated HSPG found in the basement membrane of normal bronchial epithelium, was consistently undetectable in invasive bronchogenic carcinomas. | Human | SAA1 | 6288 | serum amyloid A1 | The results of CRP and SAA examinations revealed higher values in the bronchial carcinoma patients compared to controls. The aim of the study was to examine the levels of IL-2 and soluble receptor sIL-2R involved in the activation of TH1 lymphocytes, C-reactive protein (CRP) and serum amyloid A (SAA), whose synthesis is induced by IL-6 and IL-1, in the patients with bronchial carcinoma subjected to surgical procedures. Initial results are presented on the usefulness of evaluating serum amyloid protein A (SAA) contents in patients operated for bronchial cancer. | Human | SAA@ | 6287 | serum amyloid A1 cluster | Initial results are presented on the usefulness of evaluating serum amyloid protein A (SAA) contents in patients operated for bronchial cancer. The results of CRP and SAA examinations revealed higher values in the bronchial carcinoma patients compared to controls. The aim of the study was to examine the levels of IL-2 and soluble receptor sIL-2R involved in the activation of TH1 lymphocytes, C-reactive protein (CRP) and serum amyloid A (SAA), whose synthesis is induced by IL-6 and IL-1, in the patients with bronchial carcinoma subjected to surgical procedures. | Human | CEACAM6 | 4680 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | Antisera to carcinoembryonic antigen (CEA), to a physicochemical subset of CEA, namely CEA-S, and to nonspecific cross-reacting antigen (NCA) were used for the immunohistochemical localization of these antigens in human bronchogenic carcinomas using a triple layer immunoperoxidase technique. | Human | MIF | 4282 | macrophage migration inhibitory factor (glycosylation-inhibiting factor) | In 98 cases of pulmonary diseases (active and inactive sarcoidosis, idiopathic interstitial lung fibrosis [Hamman-Rich], collagenous diseases, Goodpasture syndrome, alveolar lipoid proteinosis, malignant lymphogranulomatosis and bronchial carcinoma) and in 18 tuberculin and varidase positive, Kveim negative control cases the migration inhibition factor (MIF) was investigated. | Human | MGST1 | 4257 | microsomal glutathione S-transferase 1 | Mean expression levels (mRNA/10(3) beta-actin mRNA) in NBECs from 23 subjects without bronchogenic carcinoma compared to those from 11 subjects with bronchogenic carcinoma respectively (in parentheses) were: mGST (26.0, 6.11), GSTM3 (0.29, 0.09), combined GSTM1,2,4,5 (0.98, 0.60), GSTT1 (0.84, 0.76), GSTP1 (287, 110), GSHPx (140, 62.1), and GSHPxA (0.43, 0.34). Further, the gene expression index formed by multiplying the values for mGST x GSTM3 x GSHPx x GSHPxA x GSTP1 had a sensitivity (90%) and specificity (76%) for detecting NBECs from bronchogenic carcinoma subjects that was better than any individual gene. | Human | LOX | 4015 | lysyl oxidase | CONCLUSIONS: These results support the hypothesis that variations in lysyl oxidase expression may correlate with the invasive and metastatic potential of bronchogenic carcinoma. Lysyl oxidase expression in bronchogenic carcinoma. The present study was undertaken to test the hypothesis that lysyl oxidase mRNA and protein expression decrease with advancing tumor stage in patients with bronchogenic carcinoma. | Human | IL15 | 3600 | interleukin 15 | Therefore, we have investigated immunoreactive concentrations of IL-4, IL-6, IL-11, IL-15, IL-17, IL-18, and tumor necrosis factor-alpha (TNF-alpha) in pleural effusions and peripheral blood from patients with tuberculosis, bronchial carcinoma and other carcinomas as well as congestive heart failure (CHF) and pneumonias. | Human | IL1RN | 3557 | interleukin 1 receptor antagonist | Our laboratory has previously demonstrated that another anti-inflammatory cytokine, IL-1 receptor antagonist (IRAP) is produced and secreted by human bronchogenic carcinomas. Finally, antigenic IRAP was detected in supernatants of the human bronchogenic carcinoma cell line (A549) maintained in vitro. | Human | IGFBP1 | 3484 | insulin-like growth factor binding protein 1 | The concentrations of pregnancy protein 1 (SP1), placental-specific tissue protein 10 (PP10), placental-specific tissue protein 12 (PP12) and alpha1-Fetoprotein (AFP) were analyzed in serum samples of 83 patients with bronchial carcinoma at stages II-IV Protein levels were determined by means of single radial immunodiffusion, rocket immuno-electrophoresis, radioimmunoassay and enzyme- immunoassay. | Human | GSTM3 | 2947 | glutathione S-transferase mu 3 (brain) | Mean expression levels (mRNA/10(3) beta-actin mRNA) in NBECs from 23 subjects without bronchogenic carcinoma compared to those from 11 subjects with bronchogenic carcinoma respectively (in parentheses) were: mGST (26.0, 6.11), GSTM3 (0.29, 0.09), combined GSTM1,2,4,5 (0.98, 0.60), GSTT1 (0.84, 0.76), GSTP1 (287, 110), GSHPx (140, 62.1), and GSHPxA (0.43, 0.34). Further, the gene expression index formed by multiplying the values for mGST x GSTM3 x GSHPx x GSHPxA x GSTP1 had a sensitivity (90%) and specificity (76%) for detecting NBECs from bronchogenic carcinoma subjects that was better than any individual gene. Levels of GSTP1, GSTM3, and GSHPx were significantly (P < 0.05) lower in NBECs from subjects with bronchogenic carcinoma. | Human | GAST | 2520 | gastrin | The results show that the gastrin gene is expressed in all classes of bronchogenic carcinomas. BACKGROUND: The gastrin gene is known to be expressed in all classes of bronchogenic carcinomas. | Human | CTSK | 1513 | cathepsin K | We have investigated the cathepsin K expression in normal adult lung tissues, in embryonal lung tissue and in bronchial carcinoma. | Human | CEBPG | 1054 | CCAAT/enhancer binding protein (C/EBP), gamma | CEBPG is the transcription factor primarily responsible for regulating transcription of key antioxidant and DNA repair genes in non-bronchogenic carcinoma individuals | Human | CDA | 978 | cytidine deaminase | This suggests an approach to the treatment of human tumors possessing elevated levels of cytidine deaminase such as certain leukemias, bronchogenic carcinoma of the lung, adenocarcinomas of the colon and rectum, astrocytomas, and certain tumors which are refractory to chemotherapy with 1-beta-D-arabinofuranosylcytosine. | Human | AQP5 | 362 | aquaporin 5 | Further in situ hybridization showed that expression of AQP1, AQP3, and AQP5 were detected in tumor-infiltrating lymphocytes surrounding bronchogenic carcinoma of the lung and that expression of AQP3 and AQP5 was detected in dendritic cells. | Human | AQP3 | 360 | aquaporin 3 (Gill blood group) | Further in situ hybridization showed that expression of AQP1, AQP3, and AQP5 were detected in tumor-infiltrating lymphocytes surrounding bronchogenic carcinoma of the lung and that expression of AQP3 and AQP5 was detected in dendritic cells. | Human | ALB | 213 | albumin | albumin may have a role in progression of bronchial carcinoma | Human | SERPINA3 | 12 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | [Demonstration of alpha-1-antichymotrypsin in bronchial carcinomas. |
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