Genes (179)
Species: human : 175 mouse : 4 | |
Mouse | HHIP | 64399 | hedgehog interacting protein | Immunoprevention of basal cell carcinomas with recombinant hedgehog-interacting protein. | Mouse | SHH | 6469 | sonic hedgehog | It is shown here that transgenic mice overexpressing SHH in the skin develop many features of basal cell nevus syndrome, demonstrating that SHH is sufficient to induce basal cell carcinomas in mice. | Mouse | GLI2 | 2736 | GLI family zinc finger 2 | Human GLI2 and GLI1 are part of a positive feedback mechanism in Basal Cell Carcinoma. Basal cell carcinomas in mice overexpressing Gli2 in skin. | Mouse | GLI1 | 2735 | GLI family zinc finger 1 | Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1. Transgenic mouse models have provided evidence that activation of the zinc-finger transcription factor GLI1 by Hedgehog (Hh)-signalling is a key step in the initiation of the tumorigenic programme leading to Basal Cell Carcinoma (BCC). Mutations in this pathway induce GLI expression in basal cell carcinoma, and expression of GLI in mice is sufficient to induce these skin tumors. Gli1, a member of the Gli family of transcription factors, is expressed in BCC and in transgenic mice targeted expression of Gli1 in basal keratinocytes leads to BCC development. | Human | GGT2 | 728441 | gamma-glutamyltransferase 2 | There was no GGT expression in mesotheliomas, Hodgkins disease, non-Hodgkins lymphomas, melanomas, basal cell carcinomas, and most soft tissue sarcomas, all of which are derived from GGT-negative cells. There was no GGT expression in basal cell carcinoma or most benign skin tumours, but keratoacanthomas were weakly positive. No GGT activity was observed in basal cell epitheliomas or benign epithelial tumours, while squamous cell carcinoma and eccrine porocarcinoma exhibited intense GGT activity. | Human | TMC8 | 147138 | transmembrane channel-like 8 | | Human | FNDC1 | 84624 | fibronectin type III domain containing 1 | In situ hybridisation revealed the expression of MEL4B3 in malignant melanoma increasing with tumor depth; in basal cell carcinoma and in squamous cell carcinoma. | Human | TCF7L1 | 83439 | transcription factor 7-like 1 (T-cell specific, HMG-box) | Interestingly, high expression levels of TCF-3 were found in basal cell carcinomas and spiroadenomas. | Human | HHIP | 64399 | hedgehog interacting protein | Expression of a sonic hedgehog signal transducer, hedgehog-interacting protein, by human basal cell carcinoma. | Human | ERBB2IP | 55914 | erbb2 interacting protein | Based on our findings and on the biological activities of Erb-B2, it is conceivable that disturbed expression or functioning of ERBIN and Erb-B2 is implicated in the development of the malignant phenotype of BCC. In both SCC and KA the subcellular distribution of ERBIN and Erb-B2 remained unchanged, whereas both proteins were redistributed from the plasma membrane into cytosolic aggregates in BCC. | Human | WNT4 | 54361 | wingless-type MMTV integration site family, member 4 | We have found, in comparison with normal skin, that basal cell carcinomas have increased levels of mRNA for PTC1, GLI1, HIP, WNT2B, and WNT5a; decreased levels of mRNA for c-MYC, c-FOS, and WNT4; and unchanged levels of mRNA for PTC2, GLI2, WNT7B, and BMP2 and 4. | Human | SUFU | 51684 | suppressor of fused homolog (Drosophila) | Somatic mutations in the PTCH, SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomas. | Human | FOXP3 | 50943 | forkhead box P3 | Phenotypic Foxp3+ Tregs, in conjunction with immature dendritic cells and Th2 cytokines, suggests an attenuated state of immunity to human basal cell carcinoma | Human | DHH | 50846 | desert hedgehog | In addition, we observed Shh and Dhh transgenic skin from both phenotypes developed lesions reminiscent of human basal cell carcinoma (BCC), indicating that BCCs can be generated despite the loss of much of the proliferative (basal) compartment. | Human | DLL1 | 28514 | delta-like 1 (Drosophila) | METHODS: By in situ hybridisation, we investigated the in vivo expression of related genes, namely; Notch 1-3, Delta 1, Jagged 1, Lunatic Fringe, Radical Fringe and Manic Fringe during keratinocyte proliferation and differentiation in humans in basal cell carcinoma, psoriasis and in wound healing experiments, compared with normal adult skin. | Human | INGX | 27160 | inhibitor of growth family, X-linked, pseudogene | Loss of heterozygosity on chromosome 4q32-35 in sporadic basal cell carcinomas: evidence for the involvement of p33ING2/ING1L and SAP30 genes. | Human | AMACR | 23600 | alpha-methylacyl-CoA racemase | Melanomas, squamous cell carcinomas, basal cell carcinomas, soft tissue tumors (including epithelioid sarcomas and synovial sarcoma), thymomas, and germ cell tumors were negative for AMACR. | Human | IKZF2 | 22807 | IKAROS family zinc finger 2 (Helios) | Occurrences in females dominated those in males with a frequency distribution of 1.24:1. | Human | TMC6 | 11322 | transmembrane channel-like 6 | | Human | RNF139 | 11236 | ring finger protein 139 | We now show that the 8q24.1 breakpoint region encodes a 664-aa multiple membrane spanning protein, TRC8, with similarity to the hereditary basal cell carcinoma/segment polarity gene, patched. | Human | OGFR | 11054 | opioid growth factor receptor | Click here to display 8 evidence detail records. | Human | ERP29 | 10961 | endoplasmic reticulum protein 29 | ERP29 is expressed in a subset of basal-cell carcinoma of the skin, with the infiltrating carcinomas exhibiting the highest incidence of immunopositivity | Human | HSPH1 | 10808 | heat shock 105kDa/110kDa protein 1 | Immunohistochemistry results showed that 56% of EMPD, 60% of primary and 100% of metastatic SCC highly expressed HSP105 while only 13% of BCC lesions showed increased staining. OBJECTIVES: To assess the expression of HSP105 in skin cancers including extramammary Paget disease (EMPD), cutaneous squamous cell carcinoma (SCC) and basal cell carcinoma (BCC). CONCLUSIONS: EMPD and SCC overexpress HSP105 while BCC does not. RESULTS: Results of Western blot analysis showed overexpression of HSP105 in EMPD and SCC, and minimal expression in BCC. | Human | RGS6 | 9628 | regulator of G-protein signaling 6 | BACKGROUND: While for most human solid tumors genetic alterations of few distinct genetic regions have been found, studies on basal cell carcinomas (BCC) have shown the prevalence of several abnormalities including alterations of the three ras genes, GAP (GTPase activating protein), p53, PTCH (the human homologue of Drosophila patched) and SMOH (the human homologue of Drosophila smoothened). | Human | RECQL4 | 9401 | RecQ protein-like 4 | |
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