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Genes (85)
Species: human : 85 | |
Human | IYD | 389434 | iodotyrosine deiodinase | Diffuse cytoplasmatic localisation or downregulation of DEHAL1 expression in thyroid cancers suggests alteration or loss of DEHAL1 function during thyroid cell dedifferentiation | Human | ARL11 | 115761 | ADP-ribosylation factor-like 11 | the G446A in ARLTS1 gene is probably not associated with an increased risk of sporadic breast cancer, prostate cancer, melanoma, thyroid papillary cancer or laryngeal cancer | Human | NDRG2 | 57447 | NDRG family member 2 | Reduced expression in human thyroid cancer | Human | CBX7 | 23492 | chromobox homolog 7 | Loss of the CBX7 gene expression correlates with a highly malignant phenotype in thyroid cancer | Human | PTTG1 | 9232 | pituitary tumor-transforming 1 | Novel PTTG-mediated proliferative pathway that may be critical to thyroid cancer growth and progression PTTG may be an important gene in the mutator phenotype development in thyroid cancer | Human | TNFSF10 | 8743 | tumor necrosis factor (ligand) superfamily, member 10 | Nitric oxide-mediated S-nitrosylation of GAPDH and subsequent nuclear translocation of GAPDH might function as a mediator of TNF-related apoptosis-inducing ligand (TRAIL) induced cell death in thyroid cancer cells Bak is a regulatory molecule involved in IFNgamma-facilitated TRAIL-mediated apoptosis in thyroid cancer cells | Human | PAX8 | 7849 | paired box 8 | Pax8 may have a role in re-differentiation of thyroid cancer cells | Human | XRCC1 | 7515 | X-ray repair complementing defective repair in Chinese hamster cells 1 | Title:[Genetic polymorphisms in X-ray repair cross-complementing gene 1 and susceptibility to papillary thyroid carcinoma]|Association:Not Found|Conclusion:The Gln/Gln genotype at XRCC1 Arg399Gln site and negative life events significantly increased while X-irradiation history decreased the risk of developing PTC. | Human | WT1 | 7490 | Wilms tumor 1 | findings indicate an important role of the wild-type WT1 gene in the tumorigenesis of primary thyroid cancer | Human | VEGFC | 7424 | vascular endothelial growth factor C | VEGF-C expression is increased in papillary thyroid cancer, compared with paired normal thyroid tissues, but not in other thyroid cancers that are also prone to lymph node metastasis | Human | VEGFA | 7422 | vascular endothelial growth factor A | The A allele of the SNP rs699947 increased the risk of thyroid cancer development and regional lymph node metastasis in men Serum VEGF concentration might be used as an additional marker of thyroid cancer with distant metastases | Human | UBC | 7316 | ubiquitin C | RESULTS: cDNA array analysis showed that cyclin B1, MCM5, MCM7, RAD9, ubiquitin C, CDK6, SKP2, and APAF1 were up-regulated in malignant thyroid neoplasms. | Human | TSHR | 7253 | thyroid stimulating hormone receptor | promising new circulating markers for thyroid cancer (Review) Title:Risk of non-medullary thyroid cancer influenced by polymorphic variation in the thyroglobulin gene.|Association:Not Found|Conclusion:Although the risk of NMTC associated with the TgQ2511R - R allele is modest, its high prevalence in the general population suggests it may make a significant contribution to the incidence of NMTC. Aberrant methylation of human TSHR is a likely molecular pathway responsible for the silencing of this gene in thyroid cancers | Human | TPO | 7173 | thyroid peroxidase | Peroxidase and coupling activities of thyroid peroxidase in benign and malignant thyroid tumor tissues. Malignant thyroid tumors reportedly exhibit an anomaly in thyroid peroxidase (TPO) resulting in a lower affinity for monoclonal antibody 47 (mAb 47) in immunohistochemistry studies. CONCLUSION: We recommend adding DPP IV and TPO to the list of diagnostic tumor markers for malignant thyroid tumors of follicular cell origin. We have previously demonstrated that in 95.6% of malignant thyroid tumors the enzyme thyroid peroxidase (TPO) presents antigenic changes detectable by a monoclonal antibody termed MoAb47. In the remaining 22 malignant thyroid tumours the TPO protein level varied considerably from normal to nearly absent when compared to normal thyroid tissue or tissues from patients with Graves; disease (range less than 0.5 to more than 12.5 microg mg(-1) of protein). organification of radioiodide into proteins of thyroid cancer cells exogenously co-expressing TPO and the sodium/iodide symporter (NIS) is strictly dependent of TPO and not of NIS | Human | TP73 | 7161 | tumor protein p73 | These results indicate that in thyroid cancer cells, TAp73alpha is able to increase p53 protein level and function by interfering with Mdm2-mediated p53 degradation | Human | TP53 | 7157 | tumor protein p53 | The majority of the malignant thyroid cancers displayed aberrant expression of FHIT gene, concominant with p53 gene inactivation p53 and c-fos are significantly overexpressed in thyroid cancer patients, indicating their role in the genetic mechanisms leading to thyroid tumorigenesis | Human | THRB | 7068 | thyroid hormone receptor, beta | hypermethylation of the TRbeta gene as an alternative gene silencing mechanism is highly prevalent in thyroid cancer | Human | THRA | 7067 | thyroid hormone receptor, alpha | Title:Thyroid cancer susceptibility and THRA1 and BAT-40 repeats polymorphisms.|Association:Y|Conclusion:Therefore, our results indicate that the BAT-40 containing region and to a less extend the thyroid hormone receptor-alpha1 gene are related to thyroid cancer susceptibility. To our knowledge, this is the first study reporting the identification of genetic factors for thyroid cancer susceptibility. Less aggressive thyroid cancer was found to be linked to increased thyroid hormone receptor-alpha1 expression and an expanded THRA1 microsatellite | Human | TG | 7038 | thyroglobulin | Combined use of serum Tg levels measured just before before thyroid cancer thyroidecatomy an indicator of success, when combined wiwth I131 treaatment Title:Risk of non-medullary thyroid cancer influenced by polymorphic variation in the thyroglobulin gene.|Association:Not Found|Conclusion:Although the risk of NMTC associated with the TgQ2511R - R allele is modest, its high prevalence in the general population suggests it may make a significant contribution to the incidence of NMTC. | Human | TERT | 7015 | telomerase reverse transcriptase | Malignant thyroid tumors exhibited a greater proportion of the active full-length hTERT transcript (0.57 +/- 0.15) than inactive splice variants, alpha(-) (0.13 +/- 0.02), or beta(-)/alpha(-)beta(-) deletion transcripts (0.30 +/- 0.11; p < 0.001) | Human | STK11 | 6794 | serine/threonine kinase 11 | | Human | SLC5A5 | 6528 | solute carrier family 5 (sodium/iodide cotransporter), member 5 | NIS was found only in malignant thyroid neoplasms and in euthyroid patients; none was found in hypofunctioning thyroid tumors Protein synthesis inhibitors, in synergy with 5-azacytidine, restore sodium/iodide symporter gene expression in thyroid cancer cells Our results suggest that there is no dependence between NIS expression and iodine uptake in thyroid cancers | Human | SKP2 | 6502 | S-phase kinase-associated protein 2, E3 ubiquitin protein ligase | Skp2 plays an important role for the development of thyroid cancer | Human | SEL1L | 6400 | sel-1 suppressor of lin-12-like (C. elegans) | Title:Allele frequency of two intragenic microsatellite loci of SEL1L gene in Northern Italian population.|Association:Not Found|Conclusion:In the light of the highly polymorphic nature of both microsatellites and their intragenic location in SEL1L gene, we suggest that they could provide a means for linkage analysis to clarify the potential role of SEL1L in conferring susceptibility to IDDM or Grave's disease. | Human | SDHD | 6392 | succinate dehydrogenase complex, subunit D, integral membrane protein | Title:|Association:Not Found|Conclusion:Not Found |
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