Genes (120)
Species: human : 118 mouse : 2 | |
Mouse | NKX3-1 | 4824 | | Nkx3.1; Pten mutant mice develop invasive prostate adenocarcinoma and lymph node metastases. | Mouse | CAV1 | 857 | caveolin 1, caveolae protein, 22kDa | Re-expression of caveolin-1 is found in advanced human and mouse prostate adenocarcinomas. | Human | GGT2 | 728441 | gamma-glutamyltransferase 2 | Overall, our investigations suggest that DNA methylation and other mechanisms combine to regulate GGT gene expression in studied prostate adenocarcinoma derived cells. Most of the prostatic adenocarcinomas had GGT staining patterns and intensity similar to those of normal prostatic secretory cells, because the majority of neoplastic cells showed immunopositivity in more than 80% of the adenocarcinomas. Two human prostate adenocarcinoma cell lines, LNCaP and PC-3, were used to study the effect of 5-azacytidine on GGT gene expression, via genomic DNA methylation, and GSH content. | Human | PAOX | 196743 | polyamine oxidase (exo-N4-amino) | The combination of inhibitors of ornithine decarboxylase and polyamine oxidase, and of antibiotics suitable for the (partial) decontamination of the gastrointestinal tract, with a polyamine deficient diet, is responsible for the almost complete inhibition of the growth of MAT-LyLu prostatic adenocarcinoma. | Human | TUBA1C | 84790 | tubulin, alpha 1c | CONCLUSIONS: The beta II tubulin isotype is a potential marker for prostate adenocarcinoma. | Human | CSMD1 | 64478 | CUB and Sushi multiple domains 1 | CSMD1 expression is markedly decreased in high stage prostatic adenocarcinomas | Human | PMEPA1 | 56937 | prostate transmembrane protein, androgen induced 1 | Analysis of expressed sequence tag databases showed that STAG1/PMEPA1 also was expressed in pancreatic, endometrial, and prostatic adenocarcinomas. | Human | C21orf7 | 56911 | | TAKL was also expressed strongly in breast carcinoma GI-101, colon adenocarcinoma GI-112, and prostatic adenocarcinoma PC3. | Human | SMOX | 54498 | spermine oxidase | The combination of inhibitors of ornithine decarboxylase and polyamine oxidase, and of antibiotics suitable for the (partial) decontamination of the gastrointestinal tract, with a polyamine deficient diet, is responsible for the almost complete inhibition of the growth of MAT-LyLu prostatic adenocarcinoma. | Human | PTOV1 | 53635 | prostate tumor overexpressed 1 | In normal prostate tissue and in prostate adenomas, PTOV1 was undetectable or expressed at low levels, whereas nine out of 11 prostate adenocarcinomas showed a strong immunoreactivity, with a focal distribution in areas of carcinoma and prostatic intraepithelial neoplasia. | Human | RCHY1 | 25898 | ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase | ARNIP cDNAs cloned from NSC-34 (mouse neuroblastoma/spinal cord) or PC-3 (human prostate adenocarcinoma) mRNA encoded highly homologous 30 kDa (261 amino acids) cysteine-rich proteins with a RING-H2 (C3H2C3 zinc finger) domain; this motif is highly conserved in predicted ARNIP-homologous proteins from several other species. | Human | AMACR | 23600 | alpha-methylacyl-CoA racemase | Click here to display 24 evidence detail records. | Human | ANP32C | 23520 | acidic (leucine-rich) nuclear phosphoprotein 32 family, member C | Click here to display 5 evidence detail records. | Human | ANP32D | 23519 | acidic (leucine-rich) nuclear phosphoprotein 32 family, member D | pp32r1 and pp32r2, the oncogenic members of the pp32 family, are expressed in prostatic adenocarcinoma, while adjacent benign prostate continues to express pp32. Alternative use of genes of the closely-related pp32 family is a common occurrence in human prostate cancer. pp32r1 and pp32r2, the oncogenic members of the pp32 family, are expressed in prostatic adenocarcinoma, while adjacent benign prostate continues to express pp32. | Human | CES3 | 23491 | carboxylesterase 3 | Except for lung and ovarian carcinoma, the BR-3 gene is expressed in breast carcinoma, colon adenocarcinoma, prostatic adenocarcinoma, and pancreatic adenocarcinoma tissue samples. | Human | DICER1 | 23405 | dicer 1, ribonuclease type III | Dicer up-regulation may explain an almost global increase of microRNA expression in prostate adenocarcinoma | Human | CARM1 | 10498 | coactivator-associated arginine methyltransferase 1 | The staining intensity for CARM1 was significantly lower in benign prostate tissue specimens compared with PIN and prostatic adenocarcinoma specimens (P < 0.001). In the 12 patients with androgen-independent prostatic adenocarcinoma, the expression of CARM1 was significantly increased when compared with patients without previous hormonal treatment. In 66 patients without previous hormonal treatment, the percentage of cells that stained positively for CARM1 in benign prostate tissue specimens (mean values: cytoplasm, 23%; nucleus, 16%) was statistically significantly less than the percentage of positively stained cells in PIN (mean values: cytoplasm, 56%; nucleus, 30%; P < 0.001) and in prostatic adenocarcinoma specimens (mean values: cytoplasm, 79%; nucleus, 53%; P < 0.001). | Human | GNB2L1 | 10399 | guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 | Expression of protein kinase C (PKC) isoenzymes -alpha, -beta, -delta, -epsilon, -gamma, -iota, -lambda, -mu, -theta, and -zeta, and of their common receptor for activated C-kinase (RACK)-1, was determined immunohistochemically using specific antibodies in formalin-fixed and paraffin-embedded specimens of early prostatic adenocarcinomas (n = 23) obtained at radical prostatectomy. | Human | CRISP3 | 10321 | cysteine-rich secretory protein 3 | In situ hybridization experiments indicated that CRISP-3 mRNA is epithelial-specific and is up-regulated in prostate adenocarcinoma compared with benign prostate tissue. in situ hybridization experiments indicated that CRISP-3 mRNA is epithelial-specific and is up-regulated in prostate adenocarcinoma compared with benign prostate tissue; a potential biomarker for prostate cancer | Human | MSLN | 10232 | mesothelin | The carcinomas that did not express mesothelin included renal cell carcinomas, hepatomas, carcinomas of the thyroid, adrenal cortical carcinomas, prostatic adenocarcinomas, and carcinoid tumors. | Human | TJP2 | 9414 | tight junction protein 2 | In addition to pancreatic adenocarcinoma, ZO-2 was found to be de-regulated in breast adenocarcinoma, but not in colon or prostate adenocarcinoma. | Human | SQSTM1 | 8878 | sequestosome 1 | Cytosolic overexpression of p62 is a novel immunohistochemical characteristic in prostatic adenocarcinoma and high-grade PIN, suggesting that p62 might be a novel marker for prostatic malignancy | Human | TNFSF10 | 8743 | tumor necrosis factor (ligand) superfamily, member 10 | Glucose deprivation enhances TRAIL-induced apoptotic death as well as caspase activation (caspase-3, -9, and -8) in human prostate adenocarcinoma | Human | TP63 | 8626 | tumor protein p63 | Click here to display 11 evidence detail records. | Human | PPAP2A | 8611 | phosphatidic acid phosphatase type 2A | Identification of the phosphatidic acid phosphatase type 2a isozyme as an androgen-regulated gene in the human prostatic adenocarcinoma cell line LNCaP. |
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