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Details
Link-It Detail - Disease - Adenocarcinoma of Prostate
Debug Stats
  • ### Total Build Time: 227 ms 52.415 KB
  • CONCEPT_NAME gt=4 ms Completed: 4 ms rowSize= 350 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 1.069 KB
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=3 ms Completed: 3 ms rowSize= 14 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=0 Completed: 0 ms rowSize= 7 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 15 bytes
  • CONCEPT_RELATIONSHIPS gt=16 ms Completed: 16 ms rowSize= 15.323 KB
  • CONCEPT_GENES gt=201 ms Completed: 201 ms rowSize= 34.450 KB
  • CONCEPT_XREFS gt=2 ms Completed: 2 ms rowSize= 1.160 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Adenocarcinoma of Prostate C0007112
Definition (1)
An adenocarcinoma arising from the prostate gland. It is one of the most common malignant tumors afflicting men. The majority of adenocarcinomas arise in the peripheral zone and a minority occurs in the central or the transitional zone of the prostate gland. Grading of prostatic adenocarcinoma predicts disease progression and correlates with survival. Several grading systems have been proposed, of which the Gleason system is the most commonly used. Gleason sums of 2 to 4 represent well-differentiated disease, 5 to 7 moderately differentiated disease and 8 to 10 poorly differentiated disease. Prostatic-specific antigen (PSA) serum test is widely used as a screening test for the early detection of prostatic adenocarcinoma. Treatment options include radical prostatectomy, radiation therapy, androgen ablation and cryotherapy. Watchful waiting or surveillance alone is an option for older patients with low-grade or low-stage disease.
Relationships (39)

Relation Types:
diso_​to_​anat : 16
diso_​to_​chem : 2
diso_​to_​diso : 17
diso_​to_​gene : 4


Relationships:
gene_​associated_​with_​disease : 4
gene_​product_​malfunction_​associated_​with_​disease : 2
is_​abnormal_​cell_​of_​disease : 6
is_​associated_​anatomic_​site_​of : 3
is_​finding_​of_​disease : 3
is_​normal_​cell_​origin_​of_​disease : 1
is_​normal_​tissue_​origin_​of_​disease : 2
is_​not_​abnormal_​cell_​of_​disease : 4
is_​not_​finding_​of_​disease : 1
isa : 10
may_​be_​finding_​of_​disease : 1
may_​be_​molecular_​abnormality_​of_​disease : 2
Page Size
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Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_ANATis_abnormal_cell_of_diseaseimg Adenocarcinoma Cell C1510779
DISO_to_ANATis_abnormal_cell_of_diseaseimg Cancer Cell C0334227
DISO_to_ANATis_abnormal_cell_of_diseaseimg Carcinoma Cell C1518174
DISO_to_ANATis_normal_cell_origin_of_diseaseimg Epithelial Cells C0014597
DISO_to_ANATis_normal_tissue_origin_of_diseaseimg Epithelial Tissue C0014609
DISO_to_ANATis_associated_anatomic_site_ofimg Male Reproductive System C1963704
DISO_to_ANATis_not_abnormal_cell_of_diseaseimg Malignant Squamous Cell C1518245
DISO_to_ANATis_not_abnormal_cell_of_diseaseimg Malignant Stromal Cell C1518246
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Cell C0597032
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Epithelial Cell C1513959
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Glandular Cell C1513973
DISO_to_ANATis_not_abnormal_cell_of_diseaseimg Neoplastic Smooth Muscle Cell C1514098
DISO_to_ANATis_not_abnormal_cell_of_diseaseimg Neoplastic Squamous Cell C1514101
DISO_to_ANATis_associated_anatomic_site_ofimg Prostate C0033572
DISO_to_ANATis_normal_tissue_origin_of_diseaseimg Prostatic Epithelium C1179826
DISO_to_ANATis_associated_anatomic_site_ofimg Reproductive system C1261210
DISO_to_CHEMgene_product_malfunction_associated_with_diseaseimg coactivator-associated arginine methyltransferase 1 C0769198
DISO_to_CHEMgene_product_malfunction_associated_with_diseaseimg survivin C0664336
DISO_to_DISOisaimg Acinar Adenocarcinoma of Prostate C1332139
DISO_to_DISOis_finding_of_diseaseimg Carcinomatous Component Present C1707292
DISO_to_DISOisaimg Ductal Adenocarcinoma of Prostate C0349672
DISO_to_DISOmay_be_molecular_abnormality_of_diseaseimg ERG Gene Rearrangement C2826127
DISO_to_DISOis_finding_of_diseaseimg Epithelial Component Present C1707933
DISO_to_DISOis_finding_of_diseaseimg Invasive Lesion C1334278
DISO_to_DISOisaimg Metastatic Prostatic Adenocarcinoma C0862636
Genes (120)

Species:
human : 118
mouse : 2
Page Size
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SpeciesGeneGeneIdGene NameEvidence
MouseNKX3-14824
img NCI, Score=801, Pubmed Id: 12873978, UMLKSK CUI: C0007112
MouseCAV1857caveolin 1, caveolae protein, 22kDa
img NCI, Score=801, Pubmed Id: 12414512, UMLKSK CUI: C0007112
HumanGGT2728441gamma-glutamyltransferase 2
img NCI, Score=801, Pubmed Id: 9801800, UMLKSK CUI: C0007112
img NCI, Score=801, Pubmed Id: 9021720, UMLKSK CUI: C0007112
img NCI, Score=801, Pubmed Id: 9801800, UMLKSK CUI: C0007112
HumanPAOX196743polyamine oxidase (exo-N4-amino)
img NCI, Score=801, Pubmed Id: 1942311, UMLKSK CUI: C0007112
HumanTUBA1C84790tubulin, alpha 1c
img NCI, Score=801, Pubmed Id: 9111604, UMLKSK CUI: C0007112
HumanCSMD164478CUB and Sushi multiple domains 1
img GENERIF, Score=844, Pubmed Id: 15138198, UMLKSK CUI: C0007112
HumanPMEPA156937prostate transmembrane protein, androgen induced 1
img NCI, Score=801, Pubmed Id: 11568975, UMLKSK CUI: C0007112
HumanC21orf756911
img NCI, Score=801, Pubmed Id: 15168726, UMLKSK CUI: C0007112
HumanSMOX54498spermine oxidase
img NCI, Score=801, Pubmed Id: 1942311, UMLKSK CUI: C0007112
HumanPTOV153635prostate tumor overexpressed 1
img NCI, Score=801, Pubmed Id: 11313889, UMLKSK CUI: C0007112
HumanRCHY125898ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
img NCI, Score=801, Pubmed Id: 12200228, UMLKSK CUI: C0007112
HumanAMACR23600alpha-methylacyl-CoA racemase
Click here to display 24 evidence detail records.
HumanANP32C23520acidic (leucine-rich) nuclear phosphoprotein 32 family, member C
Click here to display 5 evidence detail records.
HumanANP32D23519acidic (leucine-rich) nuclear phosphoprotein 32 family, member D
img NCI, Score=801, Pubmed Id: 11360199, UMLKSK CUI: C0007112
img NCI, Score=801, Pubmed Id: 11360199, UMLKSK CUI: C0007112
HumanCES323491carboxylesterase 3
img NCI, Score=801, Pubmed Id: 12168825, UMLKSK CUI: C0007112
HumanDICER123405dicer 1, ribonuclease type III
img GENERIF, Score=1000, Pubmed Id: 17071602, UMLKSK CUI: C0007112
HumanCARM110498coactivator-associated arginine methyltransferase 1
img NCI, Score=801, Pubmed Id: 15221992, UMLKSK CUI: C0007112
img NCI, Score=801, Pubmed Id: 15221992, UMLKSK CUI: C0007112
img NCI, Score=801, Pubmed Id: 15221992, UMLKSK CUI: C0007112
HumanGNB2L110399guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
img NCI, Score=801, Pubmed Id: 9916928, UMLKSK CUI: C0007112
HumanCRISP310321cysteine-rich secretory protein 3
img NCI, Score=801, Pubmed Id: 12433721, UMLKSK CUI: C0007112
img GENERIF, Score=1000, Pubmed Id: 12433721, UMLKSK CUI: C0007112
HumanMSLN10232mesothelin
img NCI, Score=801, Pubmed Id: 14576474, UMLKSK CUI: C0007112
HumanTJP29414tight junction protein 2
img NCI, Score=801, Pubmed Id: 11018256, UMLKSK CUI: C0007112
HumanSQSTM18878sequestosome 1
img GENERIF, Score=1000, Pubmed Id: 16405664, UMLKSK CUI: C0007112
HumanTNFSF108743tumor necrosis factor (ligand) superfamily, member 10
img GENERIF, Score=901, Pubmed Id: 15041704, UMLKSK CUI: C0007112
HumanTP638626tumor protein p63
Click here to display 11 evidence detail records.
HumanPPAP2A8611phosphatidic acid phosphatase type 2A
img NCI, Score=801, Pubmed Id: 9468526, UMLKSK CUI: C0007112
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0007112Adenocarcinoma of Prostate0self