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Genes (165)
Species: human : 161 mouse : 4 | |
Mouse | PTK2 | 5747 | protein tyrosine kinase 2 | Enhanced FAK immunostaining is detected in small populations of preinvasive (carcinoma in situ) oral cancers and in large populations of cells in invasive oral cancers. | Mouse | JUP | 3728 | junction plakoglobin | There was no intracellular accumulation of beta- and gamma-catenin in mucosal dysplasia, papillary or nodular dysplasia, and carcinoma in situ specimens. | Mouse | HPGD | 3248 | hydroxyprostaglandin dehydrogenase 15-(NAD) | Furthermore, 15-PGDH gene knockout abrogates the normal resistance of C57BL/6J mice to colon tumor induction by the carcinogen azoxymethane (AOM), conferring susceptibility to AOM-induced adenomas and carcinomas in situ. | Mouse | ERVK3 | 2088 | | We report here that mice that inducibly express HERV-K rec show a disturbed germ cell development and may exhibit, by 19 months of age, changes reminiscent of carcinoma in situ, the predecessor lesion of classic seminoma in humans. | Human | GGT2 | 728441 | gamma-glutamyltransferase 2 | GGT 129, a polyclonal antibody directed against gamma-glutamyl transpeptidase (GGT), was used to study GGT expression in formalin-fixed paraffin-embedded tissues from normal breast, 24 benign lesions, 27 in situ carcinomas or atypical hyperplasias, and 79 infiltrating mammary carcinomas. PLAP positivity was even more pronounced in patients with cervical dysplasia and carcinoma in situ while CEA and GGT were negative. Among in situ carcinomas and atypical hyperplasias, 5/27 (19%) were negative for GGT while 22/27 were immunopositive. | Human | PCOTH | 542767 | | INFERRED, Score=800, UMLKSK CUI: C0007099 | Human | ERVK7 | 449619 | | We report here that mice that inducibly express HERV-K rec show a disturbed germ cell development and may exhibit, by 19 months of age, changes reminiscent of carcinoma in situ, the predecessor lesion of classic seminoma in humans. HERV-K expression was also found in testicular intraepithelial neoplasia (so-called carcinoma in situ) as well as in gonocytes of dysgenetic gonads. | Human | PAOX | 196743 | polyamine oxidase (exo-N4-amino) | INFERRED, Score=800, UMLKSK CUI: C0007099 | Human | ANKRD30A | 91074 | ankyrin repeat domain 30A | In tumors, carcinoma in situ and invasive carcinoma of the breast were NY-BR-1 positive whereas other tumors and normal tissues were negative. | Human | TUBA1C | 84790 | tubulin, alpha 1c | INFERRED, Score=800, UMLKSK CUI: C0007099 | Human | OR51E2 | 81285 | olfactory receptor, family 51, subfamily E, member 2 | INFERRED, Score=800, UMLKSK CUI: C0007099 | Human | NANOG | 79923 | Nanog homeobox | Our recent genome-wide gene expression profiling study of the precursor of testicular germ cell tumours, carcinoma in situ testis (CIS), showed close similarity between ESC and CIS, including high NANOG expression. | Human | ELAC2 | 60528 | elaC ribonuclease Z 2 | INFERRED, Score=800, UMLKSK CUI: C0007099 | Human | TSKS | 60385 | testis-specific serine kinase substrate | TSKS expression was very low or undetectable in seminoma, teratocarcinoma, embryonal, and Leydig cell tumors, while high expression was observed in testicular tissue adjacent to tumors which contain premalignant carcinoma in situ. | Human | MUC3B | 57876 | mucin 3B, cell surface associated | In this study, we examined the occurrence of peptide epitopes of the mucins MUC1 and MUC3 and of three mucin-associated glycotopes (TF, Tn, and s-Tn) in a series of colorectal tissue samples (normal colon, adenomas with different grades of dysplasia, carcinoma in situ, and invasive carcinomas). | Human | SMOX | 54498 | spermine oxidase | INFERRED, Score=800, UMLKSK CUI: C0007099 | Human | PTOV1 | 53635 | prostate tumor overexpressed 1 | INFERRED, Score=800, UMLKSK CUI: C0007099 | Human | GP6 | 51206 | glycoprotein VI (platelet) | INFERRED, Score=800, UMLKSK CUI: C0007099 | Human | DEC1 | 50514 | deleted in esophageal cancer 1 | This study shows that angiogenin expression is up-regulated in the cytoplasmic and nuclear compartments in in situ carcinoma and invasive carcinoma compared with normal breast tissue and that angiogenin expression in invasive carcinomas is significantly positively associated with high tumour grade (p = 0.03), positive oestrogen receptor (ER) status (p = 0.01), HIF-1 alpha (p = 0.001) and DEC 1 (p = 0.001), but not with patient age (p = 0.8), tumour size (p = 0.25), lymph node status (p = 0.69), epidermal growth factor receptor (p = 0.56) or microvessel density (p = 0.32). | Human | AMACR | 23600 | alpha-methylacyl-CoA racemase | INFERRED, Score=800, UMLKSK CUI: C0007099 | Human | ABCA5 | 23461 | ATP-binding cassette, sub-family A (ABC1), member 5 | INFERRED, Score=800, UMLKSK CUI: C0007099 | Human | PDZD2 | 23037 | PDZ domain containing 2 | INFERRED, Score=800, UMLKSK CUI: C0007099 | Human | CHEK2 | 11200 | checkpoint kinase 2 | Comparative studies of cell surface proteins (e.g. PLAP and KIT), some of the germ cell-specific markers (e.g. MAGEA4, VASA, TSPY and NY-ESO-1), supported by studies of regulatory elements of the cell cycle (e.g. p53, CHK2 and p19-INK4d) demonstrated a close similarity of CIS to primordial germ cells and gonocytes, consistent with the pre-meiotic origin of CIS. | Human | IGF2BP1 | 10642 | insulin-like growth factor 2 mRNA binding protein 1 | The relative expression of IMP1, IMP2 and IMP3 varied among tumor types and only IMP1 was detected in all carcinoma in situ cells. | Human | MSLN | 10232 | mesothelin | Two markers, fascin and mesothelin, showed up-regulation of expression with transition from carcinoma in situ to invasive adenocarcinoma, implicating a role for these markers in neoplastic progression. |
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