Logo arc image image
GATACA
  • Pin/Unpin Search
  • Pin/Unpin Details
Status:
Global Actions
Concepts: 0 (0)   Selected: 0 (0
Clear All Selections
 
Search
Text Search Results
Text Search Query:
none
Text Search Options:
none

Guided Help

Text Search Results
GraphTree Minimize or Maximize this Category
 Disease: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
GraphTree Minimize or Maximize this Category
 Anatomy: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
Minimize or Maximize this Category
 Gene: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
GraphTree Minimize or Maximize this Category
 Jax Mouse Phenotype: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
GraphTree Minimize or Maximize this Category
 Human Phenotype: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
GraphTree Minimize or Maximize this Category
 Gene Ontology: Biological Processes: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
GraphTree Minimize or Maximize this Category
 Gene Ontology: Cellular Component: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
GraphTree Minimize or Maximize this Category
 Gene Ontology: Molecular Function: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
Minimize or Maximize this Category
 Pathway: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
GraphTree Minimize or Maximize this Category
 Drug: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
Minimize or Maximize this Category
 Genomic Expression Atlas --
      Microarray Datasets: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
Minimize or Maximize this Category
 PubMed: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
GraphTree Minimize or Maximize this Category
 CoExpression Atlas: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
Minimize or Maximize this Category
 CoExpression: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
Minimize or Maximize this Category
 Interactions: 0
No results.
 Concepts (w/Genes): 0 (0)   Selected (w/genes): 0 (0)
Details
Link-It Detail - Disease - Bowens Disease
Debug Stats
  • ### Total Build Time: 65 ms 56.588 KB
  • CONCEPT_NAME gt=3 ms Completed: 3 ms rowSize= 326 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 1.086 KB
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=1 ms Completed: 1 ms rowSize= 187 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=21 ms Completed: 21 ms rowSize= 560 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 1.509 KB
  • CONCEPT_RELATIONSHIPS gt=26 ms Completed: 26 ms rowSize= 14.521 KB
  • CONCEPT_GENES gt=13 ms Completed: 13 ms rowSize= 37.240 KB
  • CONCEPT_XREFS gt=1 ms Completed: 1 ms rowSize= 1.148 KB
  • CONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Bowens Disease C0006079
Definition (1)
A form of squamous cell carcinoma in situ. It is a distinct clinicopathological entity and arises from the skin or the mucocutaneous junction. It affects predominantly white males in their 6-8th decades of life. Exposed and non-exposed skin sites are equally affected. UV damage and ingestion of inorganic arsenic may play a role in the development of the disease. On the skin surface, it presents as a single or multiple erythematous, scaly, keratotic patches or plaques. The clinical entity of erythroplasia of Queyrat is regarded as Bowen disease of the penis and it presents as an asymptomatic, red, circumscribed plaque. Morphologically, Bowen disease is characterized by the presence of hyperkeratosis, parakeratosis, dyskeratosis, and acanthosis. The keratotic squamous cells are atypical and display hyperchromatism and abnormal mitotic figures. The dermoepidermal basement membrane is intact. Complete surgical removal of the lesion may be curative.
Semantic Types (1)
Neoplastic Process (T191)
Parents (1)
img Carcinoma, Squamous Cell C0007137
Ancestral Roots
RootRoot Plus OneDepthParent
img Neoplasms C0027651img Neoplasms by Histologic Type C00276526img Carcinoma, Squamous Cell C0007137
Relationships (51)

Relation Types:
diso_​to_​anat : 16
diso_​to_​chem : 6
diso_​to_​diso : 29


Relationships:
none : 16
associated_​with : 1
entry_​version_​of : 1
is_​abnormal_​cell_​of_​disease : 6
is_​associated_​anatomic_​site_​of : 2
is_​finding_​of_​disease : 10
is_​normal_​cell_​origin_​of_​disease : 2
is_​normal_​tissue_​origin_​of_​disease : 2
is_​not_​abnormal_​cell_​of_​disease : 4
is_​not_​finding_​of_​disease : 3
may_​be_​finding_​of_​disease : 4
Page Size
Current 25
  Page 1 of 3
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_DISO153img Cutaneous tumor C0037286
DISO_to_DISO132img Cutaneous tumor C0037286
DISO_to_DISO37img Carcinoma, Squamous Cell C0007137
DISO_to_CHEM33img Aminoquinolines C0002588
DISO_to_DISO24img Carcinoma, Squamous Cell C0007137
DISO_to_DISO23img Basal cell carcinoma C0007117
DISO_to_CHEM22img Antineoplastic Agents C0003392
DISO_to_DISO19img Complication Aspects C1171258
DISO_to_CHEM18img Aminolevulinic Acid C0002563
DISO_to_DISO18img Disease due to Papilloma virus C0950124
DISO_to_CHEM17img Agents, Photosensitizing C0162713
DISO_to_CHEM17img Aminoquinolines C0002588
DISO_to_DISO15img Carcinoma in Situ C0007099
DISO_to_CHEM13img Antineoplastic Agents C0003392
DISO_to_DISO13img Disease due to Papilloma virus C0950124
DISO_to_DISO13img Keratosis C0022593
DISO_to_ANATis_abnormal_cell_of_diseaseimg Cancer Cell C0334227
DISO_to_ANATis_abnormal_cell_of_diseaseimg Carcinoma Cell C1518174
DISO_to_ANATis_normal_tissue_origin_of_diseaseimg Epidermis C0014520
DISO_to_ANATis_normal_cell_origin_of_diseaseimg Epithelial Cells C0014597
DISO_to_ANATis_normal_tissue_origin_of_diseaseimg Epithelial Tissue C0014609
DISO_to_ANATis_associated_anatomic_site_ofimg Integumentary System C0037267
DISO_to_ANATis_normal_cell_origin_of_diseaseimg Keratinocytes C0022567
DISO_to_ANATis_not_abnormal_cell_of_diseaseimg Malignant Neuroendocrine Small Round Cell C1881580
DISO_to_ANATis_abnormal_cell_of_diseaseimg Malignant Squamous Cell C1518245
Genes (28)

Species:
human : 28
Page Size
Current 25
  Page 1 of 2
Prior Page
Current 1
SpeciesGeneGeneIdGene NameEvidence
HumanEBAG99166estrogen receptor binding site associated, antigen, 9
img NCI, Score=801, Pubmed Id: 11378331, UMLKSK CUI: C0006079
HumanCLDN19076claudin 1
img NCI, Score=801, Pubmed Id: 15327539, UMLKSK CUI: C0006079
HumanTP638626tumor protein p63
img NCI, Score=801, Pubmed Id: 15268709, UMLKSK CUI: C0006079
HumanTIMP17076TIMP metallopeptidase inhibitor 1
img NCI, Score=801, Pubmed Id: 8738566, UMLKSK CUI: C0006079
HumanTCHH7062trichohyalin
img NCI, Score=801, Pubmed Id: 10228630, UMLKSK CUI: C0006079
HumanTGFB37043transforming growth factor, beta 3
img NCI, Score=801, Pubmed Id: 11454082, UMLKSK CUI: C0006079
img NCI, Score=801, Pubmed Id: 11454082, UMLKSK CUI: C0006079
img NCI, Score=801, Pubmed Id: 11454082, UMLKSK CUI: C0006079
img NCI, Score=801, Pubmed Id: 11454082, UMLKSK CUI: C0006079
HumanTGFB27042transforming growth factor, beta 2
img NCI, Score=801, Pubmed Id: 9178800, UMLKSK CUI: C0006079
HumanSTAT36774signal transducer and activator of transcription 3 (acute-phase response factor)
img GENERIF, Score=1000, Pubmed Id: 18547788, UMLKSK CUI: C0006079
HumanSPRR36707small proline-rich protein 3
img NCI, Score=801, Pubmed Id: 11069449, UMLKSK CUI: C0006079
HumanSDC26383syndecan 2
img NCI, Score=801, Pubmed Id: 2072578, UMLKSK CUI: C0006079
HumanSDC16382syndecan 1
img NCI, Score=801, Pubmed Id: 14690462, UMLKSK CUI: C0006079
HumanMAPK35595mitogen-activated protein kinase 3
img GENERIF, Score=1000, Pubmed Id: 17686614, UMLKSK CUI: C0006079
HumanMAPK15594mitogen-activated protein kinase 1
img GENERIF, Score=1000, Pubmed Id: 17686614, UMLKSK CUI: C0006079
HumanMSN4478moesin
img NCI, Score=801, Pubmed Id: 9696288, UMLKSK CUI: C0006079
img NCI, Score=801, Pubmed Id: 9696288, UMLKSK CUI: C0006079
HumanMMP134322matrix metallopeptidase 13 (collagenase 3)
img NCI, Score=801, Pubmed Id: 9242512, UMLKSK CUI: C0006079
HumanMMP124321matrix metallopeptidase 12 (macrophage elastase)
img NCI, Score=801, Pubmed Id: 10844553, UMLKSK CUI: C0006079
img NCI, Score=801, Pubmed Id: 10844553, UMLKSK CUI: C0006079
HumanMMP104319matrix metallopeptidase 10 (stromelysin 2)
img NCI, Score=801, Pubmed Id: 11237387, UMLKSK CUI: C0006079
HumanKRT163868keratin 16
img NCI, Score=801, Pubmed Id: 7509818, UMLKSK CUI: C0006079
HumanKRT13848keratin 1
img NCI, Score=801, Pubmed Id: 11512639, UMLKSK CUI: C0006079
HumanIVL3713involucrin
img NCI, Score=801, Pubmed Id: 8600780, UMLKSK CUI: C0006079
img NCI, Score=801, Pubmed Id: 6210326, UMLKSK CUI: C0006079
img NCI, Score=801, Pubmed Id: 8600780, UMLKSK CUI: C0006079
img NCI, Score=801, Pubmed Id: 8600780, UMLKSK CUI: C0006079
img NCI, Score=801, Pubmed Id: 8600780, UMLKSK CUI: C0006079
HumanHOXC43221homeobox C4
img NCI, Score=801, Pubmed Id: 7915745, UMLKSK CUI: C0006079
HumanCLDN41364claudin 4
img NCI, Score=801, Pubmed Id: 15327539, UMLKSK CUI: C0006079
HumanCDH131012cadherin 13
img NCI, Score=801, Pubmed Id: 12177241, UMLKSK CUI: C0006079
HumanCD81975CD81 molecule
img NCI, Score=801, Pubmed Id: 9470900, UMLKSK CUI: C0006079
HumanCD68968CD68 molecule
img NCI, Score=801, Pubmed Id: 9865449, UMLKSK CUI: C0006079
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0006079Bowens Disease0self