Genes (28)
Species: human : 28 | |
Human | EBAG9 | 9166 | estrogen receptor binding site associated, antigen, 9 | RCAS1 was not detected in Bowen;s disease (0/17). | Human | CLDN1 | 9076 | claudin 1 | Tight junction-associated proteins (occludin, ZO-1, claudin-1, claudin-4) in squamous cell carcinoma and Bowen;s disease. | Human | TP63 | 8626 | tumor protein p63 | We herein evaluated the expression profiles of p63, p53, survivin, and hTERT in usual skin cancers, including squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) and putative preneoplastic epidermal lesions, including actinic keratosis (AK), Bowen;s disease, and porokeratosis. | Human | TIMP1 | 7076 | TIMP metallopeptidase inhibitor 1 | Based on this background, we raised monoclonal antibodies against human gelatinase (MMP-9) and human recombinant TIMP (TIMP-1), and immunostained these two components in skin from patients with squamous cell carcinoma (SCC), Bowens disease (BD) and keratoacanthoma (KA). | Human | TCHH | 7062 | trichohyalin | Similar trichohyalin expression was found in epidermal tumours, such as seborrheic keratosis, actinic keratosis, Bowen;s disease and well-differentiated squamous cell carcinoma. | Human | TGFB3 | 7043 | transforming growth factor, beta 3 | CONCLUSIONS: The present data suggest different roles for TGF-beta3 in abnormal epidermal cells in EPD and Bowen;s disease. Thus, TGF-beta3 expression may be modulated differently via a p53-dependent or -independent pathway in the pathogenesis of EPD and Bowen;s disease. In contrast, TGF-beta3 overexpression was detected in all EPD patients, whereas downregulated TGF-beta3 expression was detected in all Bowen;s disease patients. OBJECTIVE: To clarify the role of TGF-beta3 and p53 in EPD and Bowen;s disease and to better understand the origin of these disorders. | Human | TGFB2 | 7042 | transforming growth factor, beta 2 | We have investigated the immunohistological localization of TGF-beta1, TGF-beta2, TbetaR-I and TbetaR-II in normal human skin, basal-cell carcinoma (BCC), Bowen;s disease, seborrheic keratosis, eccrine poroma and eccrine spiradenoma using frozen tissue specimens. | Human | STAT3 | 6774 | signal transducer and activator of transcription 3 (acute-phase response factor) | Overexpression of phosphorylated-ATF2 and STAT3 in cutaneous squamous cell carcinoma, Bowen's disease and basal cell carcinoma | Human | SPRR3 | 6707 | small proline-rich protein 3 | By contrast, differentiating epidermal tumours such as Bowen;s disease, keratoacanthoma and squamous cell carcinoma expressed SPRR3. | Human | SDC2 | 6383 | syndecan 2 | To investigate alterations in the basement membrane (BM) components around tumor nests, Bowen;s disease (BD), actinic keratosis (AK), basal cell epithelioma (BCE), squamous cell carcinoma (SCC) were studied by double immunofluorescent staining with antibodies to laminin (LN), type IV collagen (CIV), heparan sulfate proteoglycan (HSPG), and chondroitin 6-sulfate glycosaminoglycan (C6S). | Human | SDC1 | 6382 | syndecan 1 | Immunolabeling pattern of syndecan-1 expression may distinguish pagetoid Bowen;s disease, extramammary Paget;s disease, and pagetoid malignant melanoma in situ. | Human | MAPK3 | 5595 | mitogen-activated protein kinase 3 | expression levels of pSTAT3, pAkt, and ERK1/2 were significantly higher in squamous cell carcinoma, Bowen's disease or basal cell carinoma than in actinic keratosis or vowenoid papulosis | Human | MAPK1 | 5594 | mitogen-activated protein kinase 1 | expression levels of pSTAT3, pAkt, and ERK1/2 were significantly higher in squamous cell carcinoma, Bowen's disease or basal cell carinoma than in actinic keratosis or vowenoid papulosis | Human | MSN | 4478 | moesin | In basal cell carcinoma, Bowen;s disease, and extramammary Paget;s disease, moesin expression was either faint or negative. Using immunohistochemistry we investigated the expression of moesin in normal epidermis and various kinds of epithelial skin tumors: squamous cell carcinoma, verrucous carcinoma, Bowen;s disease, solar keratosis, keratoacanthoma, basal cell carcinoma, and extramammary Paget;s disease. | Human | MMP13 | 4322 | matrix metallopeptidase 13 (collagenase 3) | To investigate the role of the recently cloned collagenase-3 (MMP-13) in epidermal tumors, we studied samples representing malignant (basal and squamous cell carcinoma, Pagets disease), pre-malignant (Bowens disease, solar keratosis), and benign (keratoacanthoma, seborrheic keratosis, linear epidermal nevus) tumors. | Human | MMP12 | 4321 | matrix metallopeptidase 12 (macrophage elastase) | To investigate the role of human macrophage metalloelastase (MMP-12) in epidermal tumors, we studied human macrophage metalloelastase mRNA and protein expression in malignant squamous cell and basal cell carcinomas, and in premalignant Bowen;s disease. To investigate the role of human macrophage metalloelastase (MMP-12) in epidermal tumors, we studied human macrophage metalloelastase mRNA and protein expression in malignant squamous cell and basal cell carcinomas, and in premalignant Bowen;s disease. | Human | MMP10 | 4319 | matrix metallopeptidase 10 (stromelysin 2) | To investigate the role of stromelysin-2 (MMP-10) in growth and invasion of skin tumours, we studied cutaneous carcinomas with high metastatic capacity (squamous cell carcinomas, SCCs), only locally destructive tumours (basal cell carcinomas, BCCs) and pre-malignant lesions (Bowens disease and actinic keratosis) using in situ hybridization. | Human | KRT16 | 3868 | keratin 16 | These include an expression of K16 in the uninvolved skin; K16 and K6 in Bowens disease; and K16, K6 and K17 in squamous cell carcinoma and basal cell carcinoma. | Human | KRT1 | 3848 | keratin 1 | Staining with 34 beta B4 (monoclonal antibody against cytokeratin 1), which recognises the whole epidermis except for the basal layer in the normal epidermis, showed that the basal cells in the Bowens disease were completely negative, and lower layer cells in the actinic keratosis and upper layer cells in Bowens disease were only sporadically stained positive, although the superficial layer cells in actinic keratosis stained strongly and homogeneously. | Human | IVL | 3713 | involucrin | These observations suggest that there is a difference in keratin and involucrin expression between solar keratosis and Bowen;s disease and that the atypical cells of Bowen;s disease exhibit a diversity of differentiation. Cases of squamous cell carcinoma in situ (Bowen;s disease) revealed increased staining for involucrin with staining of dyskeratotic cells at all levels in the epithelium. Immunohistochemical localization of keratins and involucrin in solar keratosis and Bowen;s disease. The present study was conducted to determine the patterns of immunohistochemical characterization of keratin (K) and involucrin in solar keratosis and Bowen;s disease in order to clarify the abnormal differentiation or maturation of the tumor cells in these precancerous epithelial dermatoses. In solar keratosis, keratin and involucrin distribution was similar to that in normal epidermis, whereas in Bowen;s disease the keratin distribution varied among individual cases. | Human | HOXC4 | 3221 | homeobox C4 | Moreover, HOXC4 expression was studied in various epidermal neoplasms (solar keratosis, six specimens; Bowen;s disease, four; squamous cell carcinoma, nine; basal cell carcinoma, three) by RNA in situ hybridization. | Human | CLDN4 | 1364 | claudin 4 | Tight junction-associated proteins (occludin, ZO-1, claudin-1, claudin-4) in squamous cell carcinoma and Bowen;s disease. | Human | CDH13 | 1012 | cadherin 13 | Atypical keratinocytes in 27 of 53 specimens of actinic keratosis and 23 of 30 specimens of Bowen;s disease expressed T-cadherin. | Human | CD81 | 975 | CD81 molecule | The expression of CD9, CD81 and CD82 was markedly down-regulated in basal cell carcinoma but not in Bowen;s disease. | Human | CD68 | 968 | CD68 molecule | In the present study we tested whether CD68 and CLA+ dendritic epidermal cells were present in skin specimens of normal skin and diseased skin such as lichen planus (LP), psoriasis vulgaris (PS), discoid lupus erythematosus (DLE), basal cell epithelioma (BCE), squamous cell carcinoma (SCC), irritated seborrheic keratosis (iSK), and Bowen;s disease (BD). |
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