Relationships (79)
Relation Types: diso_to_anat : 16 diso_to_chem : 16 diso_to_diso : 40 diso_to_phen : 4 diso_to_phys : 3
Relationships: none : 30 clinically_similar : 1 is_abnormal_cell_of_disease : 6 is_finding_of_disease : 2 is_normal_cell_origin_of_disease : 3 is_normal_tissue_origin_of_disease : 2 is_not_finding_of_disease : 2 is_not_molecular_abnormality_of_disease : 3 is_not_normal_cell_origin_of_disease : 1 is_primary_anatomic_site_of_disease : 2 isa : 2 may_be_associated_disease_of_disease : 1 may_be_cytogenetic_abnormality_of_disease : 8 may_be_finding_of_disease : 6 may_be_molecular_abnormality_of_disease : 4 may_treat : 5 permuted_term_of : 1 | |
DISO_to_DISO | 125 | |
Leukemia, Myelogenous, Chronic, BCR-ABL Positive C0023473 | DISO_to_DISO | 118 | |
Leukemia, Myelogenous, Chronic, BCR-ABL Positive C0023473 | DISO_to_PHEN | 83 | |
genetic aspects C0017399 | DISO_to_PHEN | 53 | |
genetic aspects C0017399 | DISO_to_CHEM | 47 | |
Piperazines C0031958 | DISO_to_CHEM | 47 | |
Pyrimidines C0034289 | DISO_to_CHEM | 43 | |
Pyrimidines C0034289 | DISO_to_DISO | 39 | |
Leukemia, Myelocytic, Acute C0023467 | DISO_to_CHEM | 36 | |
Piperazines C0031958 | DISO_to_CHEM | 34 | |
Antineoplastic Agents C0003392 | DISO_to_CHEM | 27 | |
Antineoplastic Agents C0003392 | DISO_to_CHEM | 23 | |
Fusion Proteins, bcr-abl C0004891 | DISO_to_DISO | 18 | |
Precursor Cell Lymphoblastic Leukemia Lymphoma C1961102 | DISO_to_CHEM | 17 | |
Protein Kinase Inhibitors C1449702 | DISO_to_PHYS | 16 | |
Mutation C0026882 | DISO_to_CHEM | 15 | |
Fusion Proteins, bcr-abl C0004891 | DISO_to_DISO | 15 | |
Leukemia, Myeloid C0023470 | DISO_to_PHYS | 14 | |
GENE EXPRESSION REG LEUKEMIC C0017267 | DISO_to_ANAT | 11 | |
In Blood C0005768 | DISO_to_DISO | 11 | |
Complication Aspects C1171258 | DISO_to_DISO | 11 | |
Precursor Cell Lymphoblastic Leukemia Lymphoma C1961102 | DISO_to_PHYS | 11 | |
Drug Resistance, Neoplasm C0282588 | DISO_to_ANAT | 10 | |
In Blood C0005768 | DISO_to_DISO | 10 | |
Complication Aspects C1171258 | DISO_to_DISO | 10 | |
Dysmyelopoietic Syndromes C0026986 |
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Genes (70)
Species: human : 67 mouse : 3 | |
Mouse | NUP98 | 4928 | nucleoporin 98kDa | A murine model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9. We demonstrate that BCR/ABL cooperates with NUP98/HOXA9 to cause blast crisis in a murine model. | Mouse | JUNB | 3726 | jun B proto-oncogene | Transgenic mice specifically lacking JunB expression in the myeloid lineage (junB(-/-)Ubi-junB mice) develop a transplantable myeloproliferative disease eventually progressing to blast crisis, which resembles human chronic myeloid leukemia. Recently, it was demonstrated that transgenic mice specifically lacking JunB expression in the myeloid lineage developed a myeloproliferative disease, eventually progressing to blast crisis that resembled human chronic myeloid leukemia (CML). | Mouse | HOXA9 | 3205 | homeobox A9 | We demonstrate that BCR/ABL cooperates with NUP98/HOXA9 to cause blast crisis in a murine model. A murine model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9. | Human | PACRG | 135138 | PARK2 co-regulated | Abnormal methylation of the common promoter of PARK2 and PACRG was observed in 26% of patients with acute lymphoblastic leukemia and 20% of patients with chronic myelogenous leukemia (CML) in lymphoid blast crisis, but not in ovarian, breast, lung, neuroblastoma, astrocytoma or colon cancer cells. | Human | LHX4 | 89884 | LIM homeobox 4 | Aberrant expression of the LHX4 LIM-homeobox gene caused by t(1;14)(q25;q32) in chronic myelogenous leukemia in biphenotypic blast crisis. | Human | UBASH3B | 84959 | ubiquitin associated and SH3 domain containing B | hsp70 inhibits apoptosis upstream and downstream of the mitochondria and is a promising therapeutic target for reversing drug-resistance in chronic myeloid leukemia-blast crisis and acute myeloid leukemia cells | Human | NUDCD1 | 84955 | NudC domain containing 1 | Immunohistochemical staining for CML66 confirmed rare staining of myeloid precursors in normal marrow and diffuse staining of myeloblastic cells in acute myelogenous leukemia and blast crisis CML marrows. Expression patterns were confirmed by antigen-specific real-time PCR.RESULTS: Both CML28 and CML66 were highly expressed in leukemic blasts from patients with acute myelogenous leukemia and CML blast crisis but barely detectable in normal bone marrow, normal peripheral blood, or leukemic cells from patients with stable-phase CML. Immunohistochemical staining for CML66 confirmed rare staining of myeloid precursors in normal marrow and diffuse staining of myeloblastic cells in acute myelogenous leukemia and blast crisis CML marrows.CONCLUSIONS: The expression patterns of CML28 and CML66 are strikingly similar and suggest that antigen expression may play a role in shaping the post-DLI antibody repertoire. | Human | CDCA7 | 83879 | cell division cycle associated 7 | JPO1/CDCA7 is frequently overexpressed in human cancers, and in particular, its expression is highly elevated in chronic myelogenous leukemia blast crisis as compared with the chronic phase. | Human | CDCP1 | 64866 | CUB domain containing protein 1 | Analysis of leukemic blasts from patients with acute lymphoblastic leukemia, acute myeloid leukemia, and chronic myeloid leukemia in blast crisis revealed that CDCP1 is predominantly expressed on CD34(+)CD133+ myeloid leukemic blasts. | Human | BACH2 | 60468 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | The pattern of BACH2 expression in BCR/ABL-positive cells suggests that transcriptional repression by this regulator is impaired in CML and may contribute to the emergence of lymphoid blast crisis. | Human | AKAP13 | 11214 | A kinase (PRKA) anchor protein 13 | A proportion of patients with blast crisis of CML have blast cells identical to those found in common non-T, non-B all, and whilst this disease is often referred to as lymphoid blast crisis (LBC), evidence is presented that it may in fact arise from a prelymphoid, pre-myeloid (pluripotential) stem cell. Therapy with vincristine (2 mg i.v. weekly) and prednisolone (100 mg p.o. daily) caused a decrease in fibrinogen levels in nine patients treated for lymphoid blast crisis LBC) of chronic myeloid leukemia (CML). The identified cDNAs included signaling molecules (lymphoid blast crisis [LBC], guanine nucleotide binding protein alpha type S [Galpha-S], and mitogen kinase [MEK5]), calcium-regulated/cytoskeletal proteins (calpactin p11 and p36 subunits, vinculin, and spinocerebellar ataxia [SCA1]), growth factors (insulin-like growth factor binding protein 4 and transforming growth factor beta2), glyceraldehyde-6-phosphate dehydrogenase, an expressed sequence tag, and a novel cDNA showing homology to a LIM domain sequence. The Ht31 cDNA includes the estrogen receptor cofactor Brx and the RhoA GDP/GTP exchange factor proto-lymphoid blast crisis (Lbc) sequences. | Human | SOCS3 | 9021 | suppressor of cytokine signaling 3 | Furthermore, most of the blast cells from patients in CML blast crisis, which are usually resistant to IFN-alpha therapy, showed constitutive expression of SOCS3. These findings indicate that constitutive SOCS3 expression affects the IFN-alpha sensitivity of CML cell lines and blast cells from patients with CML blast crisis. | Human | BCL10 | 8915 | B-cell CLL/lymphoma 10 | Mutations of the BCL10 gene are not associated with the blast crisis of chronic myeloid leukaemia. Title:Mutations of the BCL10 gene are not associated with the blast crisis of chronic myeloid leukaemia.|Association:Y|Conclusion:Not Found | Human | PROM1 | 8842 | prominin 1 | DESIGN AND METHODS. A total of 298 cell samples from patients with de novo acute myeloid leukemia (AML) (n=142), acute lymphoblastic leukemia (ALL) (n=119), CD34+ve biphenotypic acute leukemia (n=13), and CD34+ve CML blast crisis (=BC; 21 myeloid BC/3 lymphoid BC) were investigated by flow cytometry for Moab AC133 reactivity.CD133 expression was compared with CD90(Thy-1) expression, another CD34-associated antigen. | Human | TP63 | 8626 | tumor protein p63 | Title:Mutation of the p51/p63 gene is associated with blastic crisis in chronic myelogenous leukemia.|Association:Y|Conclusion:Not Found | Human | HMGA2 | 8091 | high mobility group AT-hook 2 | up-regulation of HMGA2 expression is correlated to the undifferentiated phenotype of leukaemic cells accumulating during progression of chronic phase to blast crisis | Human | CXCR4 | 7852 | chemokine (C-X-C motif) receptor 4 | In vitro STI-571 treatment of CD34(+) cells from patients in blast crisis markedly increased the CXCR4 transcript and CXCR4 membrane expression. | Human | VPREB1 | 7441 | pre-B lymphocyte 1 | Chronic myeloid leukemia blast crises of the B-precursor-cell type expressed the VpreB gene while myeloid blast crises did not. | Human | UNG | 7374 | uracil-DNA glycosylase | The expression of the DNA excision repair enzyme uracil-DNA glycosylase was investigated in bone marrow and peripheral samples from seven patients with acute lymphoblastic leukemia (ALL), from 17 patients with acute non-lymphocytic leukemia (ANLL), and from one patient with chronic granulocytic leukemia (CGL) in blast crisis. The following uracil-DNA glycosylase activities were recorded (mean +/- S.D., number of samples): ALL = 45.6 +/- 14.8 U/mg of protein, N = 10; ANLL = 41.1 +/- 13.8 U/mg of protein, N = 22; CGL (blast crisis) = 44.7 U/mg of protein. | Human | TGFB2 | 7042 | transforming growth factor, beta 2 | The identified cDNAs included signaling molecules (lymphoid blast crisis [LBC], guanine nucleotide binding protein alpha type S [Galpha-S], and mitogen kinase [MEK5]), calcium-regulated/cytoskeletal proteins (calpactin p11 and p36 subunits, vinculin, and spinocerebellar ataxia [SCA1]), growth factors (insulin-like growth factor binding protein 4 and transforming growth factor beta2), glyceraldehyde-6-phosphate dehydrogenase, an expressed sequence tag, and a novel cDNA showing homology to a LIM domain sequence. | Human | TAL1 | 6886 | T-cell acute lymphocytic leukemia 1 | We next examined GATA-1, GATA-2, and SCL gene expression in 110 leukemia samples obtained from 76 patients with acute myeloid leukemia (AML), 19 with acute lymphoblastic leukemia (ALL), and 15 with chronic myeloid leukemia in blast crisis (CML-BC). | Human | STAT5B | 6777 | signal transducer and activator of transcription 5B | We found that increased transcription of BCL-X(L) gene was associated with phosphorylated STAT5 in the majority of blast crisis patients and in a few accelerated and chronic phase patients. | Human | STAT5A | 6776 | signal transducer and activator of transcription 5A | We found that increased transcription of BCL-X(L) gene was associated with phosphorylated STAT5 in the majority of blast crisis patients and in a few accelerated and chronic phase patients. | Human | SET | 6418 | SET nuclear oncogene | in BCR/ABL-transformed cells and CML blast crisis (CML-BC) progenitors, the phosphatase activity of the tumor suppressor PP2A is inhibited by the BCR/ABL-induced expression of the PP2A inhibitor SET | Human | RGS2 | 5997 | regulator of G-protein signaling 2, 24kDa | G0S8 mRNA was also detected in all cases tested of chronic myelogenous leukemia (CML) in blast crisis. |
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