Debug Stats | ### Total Build Time: 186 ms 59.385 KB CONCEPT_NAME gt=2 ms Completed: 2 ms rowSize= 330 bytesCONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytesCONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 297 bytes- Skipping details on:
CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes - Skipping details on:
CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 201 bytes- Skipping details on:
CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes CONCEPT_PARENTS gt=5 ms Completed: 5 ms rowSize= 566 bytesCONCEPT_CHILDREN gt=3 ms Completed: 3 ms rowSize= 558 bytesCONCEPT_ANCESTRAL_ROOTS gt=6 ms Completed: 6 ms rowSize= 1.508 KBCONCEPT_RELATIONSHIPS gt=148 ms Completed: 148 ms rowSize= 14.640 KBCONCEPT_GENES gt=20 ms Completed: 20 ms rowSize= 40.153 KBCONCEPT_XREFS gt=1 ms Completed: 1 ms rowSize= 1.150 KBCONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes- Reload Stats
|
Genes (133)
Species: human : 133 | |
Human | TAAR6 | 319100 | trace amine associated receptor 6 | No association of trace amine receptor genes with bipolar disorder although data do not provide evidence for an altered receptor activity of this TA4 polymorphism, an involvement in bipolar affective disorder cannot be excluded based on our in vitro data This study strongly support association of the TAAR6 gene with susceptibility to both schizophrenia and bipolar disorder in Korean patients | Human | DAOAAS | 282706 | | data suggest that a susceptibility variant for bipolar illness exists in the vicinity of the G72/G30 genes Title:|Association:Y|Conclusion:Not Found Some support for the individual involvement of DAO and G72(DAOA)/G30 in the etiology of bipolar disorder | Human | DAOA | 267012 | D-amino acid oxidase activator | The association of variation at G72 with schizophrenia as well as bipolar disorder provides molecular support for the hypothesis that these two major psychiatric disorders share some of their etiologic background data suggest that a susceptibility variant for bipolar illness exists in the vicinity of the G72/G30 genes failure to confirm originally proposed functional interaction between G72 and D-amino acid oxidase (DAO) in two tested cell lines implicating a candidate schizophrenia/bipolar disorder susceptibility gene | Human | OPN5 | 221391 | opsin 5 | Genetic variation of the hNP gene may contribute to molecular mechanisms of bipolar disorder and some aspects of memory and intelligence | Human | DGKH | 160851 | diacylglycerol kinase, eta | diacylglycerol kinase eta (DGKH) is association in the etiology of bipolar disorder | Human | TPH2 | 121278 | tryptophan hydroxylase 2 | Case-control studies support the presence of a susceptibility locus for bipolar disorder in tryptophan hydroxylase 2 No association with history of suicide was found for the -473T > A and -8396G > C polymorphisms of the TPH2 gene in subjects with schizophrenia or bipolar disorder SNPs located in a haplotype block covering the 5' region of the gene as well as a rare, non-synonymous SNP, resulting in a Pro206Ser substitution, showed significant association with bipolar disorder | Human | NTNG2 | 84628 | netrin G2 | The data of this stusty implicate NTNG2 in the pathophysiology of schizophrenia and bipolar disorder, but do not support the hypothesis that altered mRNA expression is the mechanism by which genetic variation of NTNG2 may confer disease susceptibility | Human | PPP1R1B | 84152 | protein phosphatase 1, regulatory (inhibitor) subunit 1B | Our findings suggest that PPP1R1B SNPs are unlikely to be related to the development of schizophrenia and bipolar disorder in the Japanese population The present study suggests that DARPP-32 decreases in the DLPFC of patients with schizophrenia and bipolar disorder | Human | DTNBP1 | 84062 | dystrobrevin binding protein 1 | Title:Bipolar disorder and polymorphisms in the dysbindin gene (DTNBP1).|Association:Not Found|Conclusion:Our data suggest that variation at the polymorphisms examined does not make a major contribution to susceptibility to bipolar disorder in general. They are consistent with the possibility that DTNBP1 influences susceptibility to a subset of bipolar disorder cases with psychosis. However, our subset sample is small and the hypothesis requires testing in independent, adequately powered samples. | Human | SRR | 63826 | serine racemase | Not associated with bipolar disorder in a German case-control study | Human | RTN4 | 57142 | reticulon 4 | Nogo CAA 3'UTR insertion polymorphism is not associated with schizophrenia or bipolar disorder | Human | PCDHA1 | 56147 | protocadherin alpha 1 | A polymorphic copy number variation in this locus, a 16.7-kb deletion affecting PCDH-alpha exons 8-10 (alpha 8-alpha 10 Delta), was analyzed in this study as a potential candidate variant in schizophrenia and bipolar disorder | Human | TRPV6 | 55503 | transient receptor potential cation channel, subfamily V, member 6 | These results suggest that all components, i.e. the store-operated calcium channel (SOCC), endoplasmic reticulum, and mitochondria, somehow contribute to the altered Ca2+ signalling in bipolar disorder | Human | NLGN3 | 54413 | neuroligin 3 | No structural variants were found in the NLGN3 gene when 96 unrelated patients with autism, 24 ADHD and 24 bipolar disorder patients were analyzed | Human | DISC1 | 27185 | disrupted in schizophrenia 1 | Click here to display 5 evidence detail records. | Human | DOCK9 | 23348 | dedicator of cytokinesis 9 | DOCK9 contributes to both risk and increased illness severity in bipolar disorder | Human | NTNG1 | 22854 | netrin G1 | The data of this stusty implicate NTNG1 in the pathophysiology of schizophrenia and bipolar disorder, but do not support the hypothesis that altered mRNA expression is the mechanism by which genetic variation of NTNG1 may confer disease susceptibility | Human | ATF5 | 22809 | activating transcription factor 5 | Contribution of common variations of ATF4 and ATF5 to the pathophysiology of bipolar disorder may be minimal if any | Human | CIT | 11113 | citron (rho-interacting, serine/threonine kinase 21) | Single nucleostide polymorphisms ssociated with bipolar disorder | Human | PDLIM5 | 10611 | PDZ and LIM domain 5 | Genetic association study revealed the association of single nucleotide polymorphism (SNP)1 (rs10008257) with bipolar disorder Altered expression of LIM was found in brains and lymphoblastoid cells from patients with bipolar disorder The aim of this study was to investigate the association between PDLIM5 single nucleotide polymorphisms and bipolar disorder in a case-control sample PDLIM5 may have a minor effect on susceptibility to bipolar disorder in Caucasians | Human | TOM1 | 10043 | target of myb1 (chicken) | A 3-marker haplotype of SNPs within TOM1 was associated with psychotic bipolar affective disorder linkage | Human | HMGXB4 | 10042 | HMG box domain containing 4 | high-mobility group protein 2-like 1 and SNP mapping of a psychotic bipolar affective disorder linkage region on 22q12.3 | Human | NOS1AP | 9722 | nitric oxide synthase 1 (neuronal) adaptor protein | study adds support to a role of CAPON in schizophrenia, produces new evidence implicating this gene in the etiology of bipolar disorder, and suggests a possible mechanism of action of CAPON in psychiatric illness | Human | NCOR2 | 9612 | nuclear receptor corepressor 2 | Title:Exclusion of non-synonymous SNPs and a polyglutamine tract in SMRT/N-CoR2 as common deleterious mutation for bipolar disorder in the Sagnenay-Lac-St-Jean population.|Association:Not Found|Conclusion:Our data indicated no significant allelic/genotypic association between any of the five mutations and bipolar phenotype when they were considered either individually or as haplotypes. Finally, the CAG repeat observed in SMRT/N-CoR2 did not demonstrate allelic instability and consequently it is unlikely that this polymorphism could be involved in the anticipation phenomenon reported for BP. | Human | CLOCK | 9575 | clock circadian regulator | A multi-locus interaction between rs6442925 in the 5' upstream of BHLHB2, rs1534891 in CSNK1E, and rs534654 near the 3' end of the CLOCK gene, however, is significantly associated with bipolar disorder Title:Influence of CLOCK gene polymorphism on circadian mood fluctuation and illness recurrence in bipolar depression.|Association:Y|Conclusion:This preliminary observation leads to hypothesize a role for the CLOCK gene polymorphism in the regulation of long-term illness recurrence in bipolar disorder. Given the post-hoc nature of the finding, replication in independent samples is necessary to confirm it. a role for the CLOCK gene polymorphism in the regulation of long-term illness recurrence in bipolar disorder |
|