Genes (51)
Species: human : 51 | |
Human | MAGED4B | 81557 | melanoma antigen family D, 4B | The expressions of the six candidates for a suitable RT-PCR marker [mammaglobin B, carcinoembryonic antigen (CEA), cytokeratin (CK) 20, prostate-specific antigen, and melanoma antigens (MAGE-1 and MAGE-3)] were evaluated in two bile duct cancer cell lines and human biliary tract carcinoma tissues. | Human | CHFR | 55743 | checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase | The methylation frequencies of CHFR, DAP-kinase, E-cadherin, hMLH1, p16, RASSF1A, and RUNX3 genes were 16.2%, 21.4%, 27.0%, 8.1%, 24.3%, 27.0%, and 56.8%, respectively, in primary biliary tract carcinomas. | Human | SH3GLB1 | 51100 | SH3-domain GRB2-like endophilin B1 | INFERRED, Score=800, UMLKSK CUI: C0005426 | Human | GMNN | 51053 | geminin, DNA replication inhibitor | Several pathways integral to tumorigenesis were up-regulated in the biliary cancers, including proliferation and cell cycle antigens (eg, cyclins D2 and E2, cdc2/p34, and geminin), transcription factors (eg, homeobox B7 and islet-1), growth factors and growth factor receptors (eg, hepatocyte growth factor, amphiregulin, and insulin-like growth factor 1 receptor), and enzymes modulating sensitivity to chemotherapeutic agents (eg, cystathionine beta synthase, dCMP deaminase, and CTP synthase). | Human | KEAP1 | 9817 | kelch-like ECH-associated protein 1 | INFERRED, Score=800, UMLKSK CUI: C0005426 | Human | EBAG9 | 9166 | estrogen receptor binding site associated, antigen, 9 | We speculate that RCAS1 is a clinically more significant serum marker for biliary neoplasms than CA19-9. BACKGROUND: We have demonstrated immunohistochemically that RCAS 1 antigen is expressed in biliary neoplasms. | Human | CES2 | 8824 | carboxylesterase 2 | INFERRED, Score=800, UMLKSK CUI: C0005426 | Human | VEGFC | 7424 | vascular endothelial growth factor C | INFERRED, Score=800, UMLKSK CUI: C0005426 | Human | TP53 | 7157 | tumor protein p53 | INFERRED, Score=800, UMLKSK CUI: C0005426 | Human | TOP2A | 7153 | topoisomerase (DNA) II alpha 170kDa | INFERRED, Score=800, UMLKSK CUI: C0005426 | Human | TNF | 7124 | tumor necrosis factor | INFERRED, Score=800, UMLKSK CUI: C0005426 | Human | TGFB1 | 7040 | transforming growth factor, beta 1 | INFERRED, Score=800, UMLKSK CUI: C0005426 | Human | STK11 | 6794 | serine/threonine kinase 11 | Loss of Stk11/Lkb1 expression in pancreatic and biliary neoplasms. We investigated the role of STK11/LKB1 in the development of pancreatic and biliary cancer in patients with and without the PJS. Stk11 expression was lost in 4 of the 56 (7%) pancreatic adenocarcinomas and 1 of the 38 (2.6%) biliary cancers by immunohistochemistry; the absence of labeling was confirmed by repeated immunohistochemical labeling of complete tissue sections for the same cases. Germline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancers. In this report, we characterize the expression of Stk11, the protein product of the STK11 gene, in a larger series of pancreatic and biliary neoplasms. Subsequently, to further evaluate Stk11 expression in pancreatic and biliary neoplasms, tissue microarrays (TMAs) were constructed from a series of nearly 100 ductal adenocarcinomas and biliary neoplasms. Thus, Stk11 expression is abrogated in a small proportion of pancreatic and biliary neoplasms. | Human | SPINK1 | 6690 | serine peptidase inhibitor, Kazal type 1 | The bile concentrations of trypsinogen-1, -2 and tumour-associated trypsin-inhibitor (TATI) were determined in 23 patients with benign biliary tract disease, two with biliary tract cancer, and in 15 with pancreatic cancer. We also examined the trypsinogen and TATI expression by immunohistochemistry in tissue specimens from biliary tract cancer and non-neoplastic extrahepatic biliary tract. | Human | SKP2 | 6502 | S-phase kinase-associated protein 2, E3 ubiquitin protein ligase | Skp2 overexpression is a p27Kip1-independent predictor of poor prognosis in patients with biliary tract cancers. | Human | PDGFRB | 5159 | platelet-derived growth factor receptor, beta polypeptide | The expression of c-kit and PDGFR mRNA was examined in 12 biliary tract cancer cell lines using RT-PCR. | Human | OGG1 | 4968 | 8-oxoguanine DNA glycosylase | INFERRED, Score=800, UMLKSK CUI: C0005426 | Human | NME1 | 4830 | NME/NM23 nucleoside diphosphate kinase 1 | BACKGROUND. The nm23-H1 gene encodes a 17-kilodalton cytoplasmic and nuclear protein that has recently been shown to be reduced in a number of human carcinomas including breast, colorectal, lung, gallbladder, and biliary tract carcinomas. | Human | NFE2L2 | 4780 | nuclear factor, erythroid 2-like 2 | INFERRED, Score=800, UMLKSK CUI: C0005426 | Human | MTHFR | 4524 | methylenetetrahydrofolate reductase (NAD(P)H) | INFERRED, Score=800, UMLKSK CUI: C0005426 | Human | MTAP | 4507 | methylthioadenosine phosphorylase | Inhibitors of de novo purine synthesis can be a potential mechanism-based strategy for treatment of biliary tract cancers, one third of which show complete loss of MTAP function. Immunolabeling for MTAP was lost in 91 of the 300 (30%) evaluable pancreatic cancers, 9 of 54 (17%) ampullary cancers, 4 of 33 (12%) biliary cancers, and in 1 of 35 (3%) IPMNs. In this study, we determine that 10 of 28 (35%) biliary tract cancers show complete lack of Mtap protein expression. Homozygous deletions of methylthioadenosine phosphorylase in human biliary tract cancers. In vitro analysis using a selective inhibitor of the de novo purine synthesis pathway, l-alanosine, shows robust growth inhibition in MTAP-negative biliary cancer cell lines CAK-1 and GBD-1 accompanied by striking depletion of intracellular ATP and failure to rescue this depletion via addition of exogenous methylthioadenosine, the principal substrate of the MTAP gene product; in contrast, no significant effects were observed in MTAP-expressing HuCCT1 and SNU308 cell lines. | Human | MSH2 | 4436 | mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) | Uncertain pathogenicity of MSH2 variants N127S and G322D in genetic predisposition for colorectal, endometrial, pancreatic and biliary tract neoplasms | Human | MGMT | 4255 | O-6-methylguanine-DNA methyltransferase | INFERRED, Score=800, UMLKSK CUI: C0005426 | Human | SCGB2A1 | 4246 | secretoglobin, family 2A, member 1 | Our findings suggest that mammaglobin B and CEA could be useful RT-PCR markers for the detection of lymph node micrometastases in biliary tract carcinomas. The expressions of the six candidates for a suitable RT-PCR marker [mammaglobin B, carcinoembryonic antigen (CEA), cytokeratin (CK) 20, prostate-specific antigen, and melanoma antigens (MAGE-1 and MAGE-3)] were evaluated in two bile duct cancer cell lines and human biliary tract carcinoma tissues. We then examined 209 lymph nodes obtained from 15 patients with biliary tract carcinoma by RT-PCR assay using both mammaglobin B and CEA and compared the results with those of histological examination. | Human | MAGEA1 | 4100 | melanoma antigen family A, 1 (directs expression of antigen MZ2-E) | The expressions of the six candidates for a suitable RT-PCR marker [mammaglobin B, carcinoembryonic antigen (CEA), cytokeratin (CK) 20, prostate-specific antigen, and melanoma antigens (MAGE-1 and MAGE-3)] were evaluated in two bile duct cancer cell lines and human biliary tract carcinoma tissues. |
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