Genes (21)
Species: human : 21 | |
Human | ANXA10 | 11199 | annexin A10 | The most up-regulated genes in BE compared with squamous epithelium were trefoil factors, annexin A10, and galectin-4. | Human | PTGES | 9536 | prostaglandin E synthase | The aim of the present paper was to evaluate the expression of cyclooxygenase (COX) and microsomal prostaglandin E synthase (mPGES) in gastric-type and intestinal-type metaplasia in columnar-lined esophagus and compare these with cell proliferation. The aim of the present paper was to evaluate the expression of cyclooxygenase (COX) and microsomal prostaglandin E synthase (mPGES) in gastric-type and intestinal-type metaplasia in columnar-lined esophagus and compare these with cell proliferation. | Human | CES2 | 8824 | carboxylesterase 2 | Altered Expression of TFF-1 and CES-2 in Barrett;s Esophagus and Associated Adenocarcinomas. | Human | TFF2 | 7032 | trefoil factor 2 | Barrett;s esophagus is characterized by expression of gastric-type mucins (MUC5AC, MUC6) and TFF peptides (TFF1 and TFF2), but the risk of carcinoma development may be indicated by the intestinal-type mucin, MUC2. In the total group of BE patients, H. pylori infection of the stomach correlated with decreased TFF2 expression in the BE epithelium. We conclude that BE is best characterized by the specific expression of the gastric-type markers, MUC5AC, MUC6, TFF1, and TFF2. | Human | TFF1 | 7031 | trefoil factor 1 | Barretts esophagus is characterized by expression of gastric-type mucins (MUC5AC, MUC6) and TFF peptides (TFF1 and TFF2), but the risk of carcinoma development may be indicated by the intestinal-type mucin, MUC2. | Human | SOD2 | 6648 | superoxide dismutase 2, mitochondrial | Expression of Cu, ZnSOD and MnSOD isoforms were present in normal mucosa and increased according to the severity of the lesion, reaching the highest level in Barrett;s esophagus. | Human | PITX1 | 5307 | paired-like homeodomain 1 | METHODS: CDX2 and PITX1 messenger RNA (mRNA) expression levels, relative to the control gene beta-actin, were measured by reverse transcription-polymerase chain reaction in specimens of Barrett;s IM (n = 21), dysplasia (n = 18), adenocarcinoma (n = 20), and matching normal squamous esophagus tissues (n = 39) collected from 19 patients with Barrett;s esophagus and 20 patients with esophageal adenocarcinoma. In contrast, PITX1 mRNA expression is decreased in Barrett;s esophagus, compared with matching normal squamous esophagus specimens, and is further decreased in Barrett;s-associated cancer. Relative median PITX1 mRNA expression was decreased in Barrett;s esophagus (8.02 for all specimens), compared with normal esophagus specimens (47.46 for all specimens, P _lt_ .001), and was further reduced in cancer specimens (2.21), compared with either Barrett;s esophagus or normal esophagus (both P _lt_ .001). Increased CDX2 and decreased PITX1 homeobox gene expression in Barrett;s esophagus and Barrett;s-associated adenocarcinoma. | Human | PGC | 5225 | progastricsin (pepsinogen C) | Pepsinogen C: a possible biological marker of epithelial differentiation in Barrett;s esophagus. Precursors of the gastric proteases pepsinogen A (pepsinogen I) and pepsinogen C (pepsinogen II) and slow-moving protease were demonstrated in biopsy specimens from Barrett;s epithelium in 21 of 22 patients with Barrett;s esophagus; in 14 of them, in variable combinations at different sites. | Human | MUC5AC | 4586 | mucin 5AC, oligomeric mucus/gel-forming | METHODS: We studied three types of human tissue producing MUC5AC: Barrett;s esophagus (BE), normal gastric tissue, and gastric metaplasia of the duodenum (GMD). Immunoreactivity with MUC1, MUC2, MUC5AC, Das-1, cytokeratins 7 and 20, inducible nitric oxide synthase and cyclooxygenase-2 antibodies was also significantly greater in Barrett;s esophagus than in gastric intestinal metaplasia. Biopsy specimens of 30 columnar-lined esophagus patients were collected, and immunohistochemistry was performed for secretory mucins (MUC2, MUC5AC), COX, mPGES and cell proliferation (Ki-67). Barrett;s esophagus is characterized by expression of gastric-type mucins (MUC5AC, MUC6) and TFF peptides (TFF1 and TFF2), but the risk of carcinoma development may be indicated by the intestinal-type mucin, MUC2. | Human | MTAP | 4507 | methylthioadenosine phosphorylase | Complete loss of MTAP and p16 was seen in 4 of 25 (16%) patients with Barrett;s esophagus, 4 of 18 (22%) with low-grade dysplasia, 5 of 39 (13%) with high-grade dysplasia, 17 of 78 (22%) with invasive adenocarcinoma, and 8 of 36 (22%) of metastases. | Human | MCM2 | 4171 | minichromosome maintenance complex component 2 | PURPOSE: The purpose is to determine whether a novel cell cycle marker, minichromosome maintenance protein 2 (Mcm2), predicted esophageal adenocarcinoma (AC) risk in Barrett;s esophagus (BE) and whether this could be used in combination with a surface sampling method. | Human | LTA4H | 4048 | leukotriene A4 hydrolase | In tissue sections from 20 EGDA rats and 92 patients (86 with EAC, one with dysplasia, and five with columnar-lined esophagus), LTA4H was expressed in infiltrating inflammatory cells and overexpressed in the columnar cells of preinvasive lesions and cancers, especially in well-differentiated EACs, as compared with the basal cells of the normal esophageal squamous epithelium. | Human | KRT13 | 3860 | keratin 13 | RESULTS: No differences were encountered regarding staining patterns for CK13 and CaCO3/73 in Barrett;s esophagus and cardia. | Human | GRB7 | 2886 | growth factor receptor-bound protein 7 | No alterations, neither gene amplification nor overexpression were detected in Barrett;s carcinoma associated low grade intraepithelial neoplasia (LGIN), intestinal metaplasia (IM) and squamous epithelium, indicating that alterations of GRB7 and ERBB2 are late events in the carcinogenesis of Barrett;s esophagus. | Human | GPX2 | 2877 | glutathione peroxidase 2 (gastrointestinal) | Biopsy samples of oesophageal mucosa of patients with Barrett;s esophagus (n = 12), patients with squamous restoration after thermal ablation (n = 10), and healthy controls (n = 5) were analyzed for pGPx and GI-GPx mRNA expression by Northern blot and for glutathione peroxidase activity by enzymatic assay. | Human | FRZB | 2487 | frizzled-related protein | Aberrant methylation of secreted frizzled-related protein genes in esophageal adenocarcinoma and Barrett;s esophagus. Aberrant methylation of secreted frizzled-related protein genes in esophageal adenocarcinoma and Barrett;s esophagus. | Human | FGF1 | 2246 | fibroblast growth factor 1 (acidic) | This suggests that FGF-1 immunohistochemistry could be used as an adjunct to the routine histopathologic diagnosis of dysplasia in Barretts esophagus. Acidic fibroblast growth factor 1 (FGF-1) is sequentially accumulated in Barretts esophagus and its expression in glandular dysplasias is independent of esophageal adenocarcinoma. | Human | EZH2 | 2146 | enhancer of zeste homolog 2 (Drosophila) | The current study examined the correlation between the immunohistochemical expression of pRb2/p130, VEGF, EZH2, p53, p16, p21(waf-1), p27, and PCNA in Barrett;s esophagus (BE). Immunohistochemical evaluation of pRb2/p130, VEGF, EZH2, p53, p16, p21(waf-1), p27, and PCNA in Barrett;s esophagus. | Human | EYA4 | 2070 | eyes absent homolog 4 (Drosophila) | This study was designed to explore the natural history of eyes absent 4 (EYA4) gene methylation in the neoplastic progression of Barrett;s esophagus and to evaluate methylated EYA4 as a candidate marker. Results indicate that aberrant promoter methylation of EYA4 is very common during tumorigenesis in Barrett;s esophagus, occurs in early metaplasia, seems to be an important mechanism of down-regulating EYA4 expression, and represents an intriguing candidate marker for Barrett;s metaplasia and esophageal cancer. Aberrant promoter methylation of EYA4 was studied by methylation-specific PCR using bisulfite-treated DNA from esophageal adenocarcinomas, Barrett;s esophagus, and normal epithelia, and then confirmed by sequencing. | Human | ENG | 2022 | endoglin | Endoglin showed a significant increase in MV count in Barrett;s esophagus with high-grade dysplasia when compared with Barrett;s esophagus low-grade dysplasia (P < .01), whereas CD31 did not show any significant difference. | Human | FRA3B | 0 | | To further study the relationship of FRA3B to the findings regarding the FHIT gene and to determine the extent of FHIT mRNA alterations in early stages of tumor development, the status of the FHIT gene was evaluated in the premalignant condition of Barrett;s esophagus and associated esophageal adenocarcinomas. |
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