Human | NLRP2 | 55655 | NLR family, pyrin domain containing 2 | is phosphorylated by ATM, the product of the Nbs1, an ataxia-telangiectasia mutated gene and a member of the phosphatidylinositol 3-kinase-related family of serine-threonine kinasesin response to DNA double-strand breaks |
Human | ZNF148 | 7707 | zinc finger protein 148 | ataxia telangiectasia mutated protein phosphorylation of ZBP-89 contributes to Histone deacetylase inhibitors induction of p21(waf1) gene expression |
Human | TYR | 7299 | tyrosinase | tyrosinase overexpression promotes an ataxia telangiectasia mutated-dependent p53 phosphorylation by quercetin treatment and sensitizes melanoma cells to dacarbazine |
Human | TERT | 7015 | telomerase reverse transcriptase | Stress-induced premature senescence in hTERT-expressing ataxia telangiectasia fibroblasts |
Human | TERC | 7012 | telomerase RNA component | A novel telomerase-independent function of human telomerase RNA is uncovered that restrains ataxia telangiectasia and Rad3 related (ATR) checkpoint kinase activity and participates in the recovery of cells from UV radiation |
Human | RPS6KA3 | 6197 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | This protein is mutated in ataxia telangiectasia and is involved in the phoshphorylation of STAT3 |
Human | UPF1 | 5976 | UPF1 regulator of nonsense transcripts homolog (yeast) | regulated degradation of histone mRNAs requires Upf1, a key regulator of the nonsense-mediated decay pathway, and ataxia telangiectasia and Rad3 related, a key regulator of the DNA damage checkpoint pathway activated during replication stress |
Human | PMS2 | 5395 | PMS2 postmeiotic segregation increased 2 (S. cerevisiae) | Data show that DNA damage induces the accumulation of hPMS1, hPMS2, and hMLH1 through ataxia-telangiectasia-mutated (ATM)-mediated protein stabilization |
Human | NBN | 4683 | nibrin | Data suggest that Nijmegen breakage syndrome 1 (Nbs1) functions in both ATR- (ataxia-telangiectasia and Rad3-related protein) and ataxia telangiectasia mutated protein-dependent signalling |
Human | MRE11A | 4361 | MRE11 meiotic recombination 11 homolog A (S. cerevisiae) | MRE11 gene mutations affected ATM-dependent responses in radiosensitive ataxia-telangiectasia-like disorder family Assessment of carriers' frequency of a novel MRE11A mutation responsible for the rare ataxia telangiectasia-like disorder is presented early-onset, slowly progressive, ataxia plus ocular apraxia phenotype = ataxia telangiectasia-like disorder (ATLD) |
Human | MCM7 | 4176 | minichromosome maintenance complex component 7 | ATM/ATR-dependent (ataxia-telangiectasia-mutated/ATM- and Rad3-related) checkpoint pathways are directly linked to three members of the MCM complex(MCM2,MCM3,MCM7) |
Human | HPRT1 | 3251 | hypoxanthine phosphoribosyltransferase 1 | High frequency of deletions at the hypoxanthine-guanine phosphoribosyltransferase locus in an ataxia-telangiectasia lymphoblastoid cell line irradiated with gamma-rays |
Human | H2AFX | 3014 | H2A histone family, member X | implicate ataxia telangiectasia mutated as the phosphoinositide 3-kinase related protein kinases that phosphorylates H2AX in response to DNA damage caused by cigarette smoke |
Human | CDKN1A | 1026 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | HDACi induction of the cyclin-dependent kinase inhibitor p21(waf1) has been shown to require ataxia-telangiectasia mutated (ATM) ataxia telangiectasia mutated protein phosphorylation of ZBP-89 contributes to HDACi induction of p21(waf1) gene expression |
Human | BCL6 | 604 | B-cell CLL/lymphoma 6 | Bcl-6 mediates the B cell phenotype by directly targeting the ataxia telangiectasia- and Rad3-related (ATR) gene in centroblasts and lymphoma cells |
Human | ATR | 545 | ataxia telangiectasia and Rad3 related | Caused by mutation in the ataxia-telangiectasia and Rad3-related gene (ATR, {601215.0001}) |
Human | ATM | 472 | ataxia telangiectasia mutated | Click here to display 16 evidence detail records. |
Human | AKT1 | 207 | v-akt murine thymoma viral oncogene homolog 1 | AKT is activated in an ataxia telangiectasia and Rad3-related-dependent manner in response to temozolomide and confers protection against drug-induced cell growth inhibition |