Human | CCR2 | 729230 | chemokine (C-C motif) receptor 2 | the CCR2-64*I allele is more common in asthmatic patients, especially among atopic subjects |
Human | SFTPA1 | 653509 | surfactant protein A1 | Polymorphisms within SFTPA loci may be associated with wheeze and persistent cough in white infants at risk for asthma |
Human | NPS | 594857 | neuropeptide S | Because remodeling of airway epithelium is a feature of chronic asthma, the up-regulation of MMP10 and TIMP3 by NPS-NPSR1 signaling may be of relevance in the pathogenesis of asthma the key residues of NPS involved in NPSR activation and suggest a molecular basis for the functional effects of the N107I mutation and for its putative pathophysiological link with asthma |
Human | GTF2H5 | 404672 | general transcription factor IIH, polypeptide 5 | |
Human | NPSR1 | 387129 | neuropeptide S receptor 1 | Click here to display 12 evidence detail records. |
Human | TRG@ | 281523 | | Title:|Association:Not Found|Conclusion:Not Found |
Human | IL27 | 246778 | interleukin 27 | Our results strongly suggest that the g.-964A > G polymorphism of IL-27p28 is most likely associated with susceptibility to asthma |
Human | ATOD5 | 117188 | Dermatitis, atopic, 5 | |
Human | ATOD3 | 117187 | Dermatitis, atopic, 3 | |
Human | SCGB3A2 | 117156 | secretoglobin, family 3A, member 2 | Click here to display 6 evidence detail records. |
Human | RASGRP4 | 115727 | RAS guanyl releasing protein 4 | identification of defective variants of this signaling protein in asthma, mastocytosis, and mast cell leukemia patients and demonstration of the importance of RasGRP4 in mast cell development and function |
Human | ATOD6 | 114477 | Dermatitis, atopic, 6 | |
Human | ORMDL3 | 94103 | ORM1-like 3 (S. cerevisiae) | A common genetic variation at a locus (rs7216389) controlling expression of the ORMDL3 gene increases patient susceptibility to asthma and is associated with poor control of asthma symptoms in children and young adults results confirm associations between two SNPs within ORMDL3 and asthma in Mexicans and African Americans, and a trend toward association in Puerto Ricans ORMDL3 variants associated with asthma susceptibility in North Americans of European ancestry |
Human | TSLP | 85480 | thymic stromal lymphopoietin | There is distinct airways expression of TSLP and chemokines which preferentially attract T helper (Th) type 1- and Th2-type T cells, and influx of T cells bearing their receptors in asthma and chronic obstructive pulmonary disease Elevated bronchial mucosal expression of TSLP is implicated in asthma pathogenesis; its action is partly through selective development and retention, or recruitment of T helper type 2, not Th1, receptor-bearing cells |
Human | HAVCR2 | 84868 | hepatitis A virus cellular receptor 2 | Title:Genetic variants of the T-cell immunoglobulin mucin 1 but not the T-cell immunoglobulin mucin 3 gene are associated with asthma in an African American population|Association:Not Found|Conclusion:Our findings suggest that the genetic variants of the TIM-1 but not the TIM-3 gene contribute to asthma susceptibility in this African-American population. |
Human | TLR10 | 81793 | toll-like receptor 10 | Title:TOLL-like receptor 10 genetic variation is associated with asthma in two independent samples.|Association:Y|Conclusion:Consistent association in two independent samples and association with an intermediate phenotype provides strong support for TLR10 genetic variation contributing to asthma risk. |
Human | ADAM33 | 80332 | ADAM metallopeptidase domain 33 | Click here to display 16 evidence detail records. |
Human | TRPM8 | 79054 | transient receptor potential cation channel, subfamily M, member 8 | TRPM8 variant receptor may function as a modulator of respiratory physiology caused by cold air, and may partially explain asthmatic respiratory hypersensitivity to cold air |
Human | IL25 | 64806 | interleukin 25 | Blocking IL-25 in an experimental model of allergic asthma prevents airway hyperresponsiveness, a critical feature of clinical asthma |
Human | DPP10 | 57628 | dipeptidyl-peptidase 10 (non-functional) | No consistent association was found between DPP10 and asthma susceptibility |
Human | AICDA | 57379 | activation-induced cytidine deaminase | Title:[Correlation between activation-induced cytidine deaminase gene polymorphism and atopic asthma and plasma IgE in adult]|Association:Y|Conclusion:The 8408 T/T genotype of AICDA is correlated with atopic asthma and total plasma IgE level in adult. Title:Polymorphisms of IL-4, IL-4R alpha, and AICDA genes in adult allergic asthma.|Association:Y|Conclusion:These data suggested that the IL-4R alpha chain 576R/R and AICDA 8408T/T genotypes confer genetic susceptibility to adult allergic asthma in China. |
Human | CYSLTR2 | 57105 | cysteinyl leukotriene receptor 2 | CYSLTR2 and ALOX5 polymorphisms may predispose a minority of individuals to excessive cysteinyl-leukotriene concentrations, yielding a distinct asthma phenotype most likely to respond to leukotriene modifier pharmacotherapy identified three novel exons in the 5' untranslated region of CYSLTR2 and eight novel polymorphisms; the -1220A > C polymorphism is associated with the development of asthma |
Human | CCL28 | 56477 | chemokine (C-C motif) ligand 28 | CCL28 is one link between microbial insult and the exacerbation of pathologies such as asthma, through an NFkappaB-dependent mechanism |
Human | ITLN1 | 55600 | intelectin 1 (galactofuranose binding) | we have found evidence of a possible association between a single nucleotide polymorphism in intelectin-1 and asthma susceptibility that requires to be confirmed by independent studies |
Human | TLR9 | 54106 | toll-like receptor 9 | it was concluded that TLR9 and CD14 gene polymorphisms may contribute to an inherited predisposition to asthma in Tunisian children |