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Genes (34)
Species: human : 34 | |
Human | LOC100507436 | 100507436 | | MICA is associated with susceptibility to psoriatic arthritis Title:Polymorphism in MICA rather than HLA-B/C genes is associated with psoriatic arthritis in the Jewish population.|Association:Y|Conclusion:These results suggest that the MICA gene or other nearby gene(s) may be involved in the development of PsA, and it would thus appear that psoriasis vulgaris (PsV) and PsA are associated with different MHC susceptibility genes. | Human | KIR2DS2 | 100132285 | killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2 | Title:|Association:Not Found|Conclusion:Not Found | Human | NEWENTRY | 192343 | Record to support submission of GeneRIFs for a gene not in Gene (human; man). | There was an increased frequency of the (*)2 allele of HS1,2-A in dermatitis herpetiformis, plaque psoriatic, and psoriatic arthritis patients | Human | IL23R | 149233 | interleukin 23 receptor | Variation within IL23R and IL12B is associated with susceptibility to both psoriasis and psoriatic arthritis | Human | NOD2 | 64127 | nucleotide-binding oligomerization domain containing 2 | no evidence for association in the examined population for CARD15 polymorphisms in psoriatic arthritis represents a pleiotropic autoimmune gene and is the first non-MHC gene to be associated with psoriatic arthritis | Human | PSORS5 | 63870 | psoriasis susceptibility 5 | Title:Analysis of 6 genetic loci for disease susceptibility in psoriatic arthritis.|Association:Not Found|Conclusion:We identified an association between psoriatic arthritis and one of the microsatellite markers within the TNFB locus at the HLA region on chromosome 6. Linkage disequilibrium between TNFB123 and certain HLA-B antigens was found. | Human | PTPN22 | 26191 | protein tyrosine phosphatase, non-receptor type 22 (lymphoid) | Moderate association of the R620W variant of PTPN22 with psoriatic arthritis in the Toronto population only Variant R620W of PTPN22 play a role in susceptibility to psoriatic arthritis in men | Human | PSORS4 | 10547 | psoriasis susceptibility 4 | Title:Analysis of 6 genetic loci for disease susceptibility in psoriatic arthritis.|Association:Not Found|Conclusion:We identified an association between psoriatic arthritis and one of the microsatellite markers within the TNFB locus at the HLA region on chromosome 6. Linkage disequilibrium between TNFB123 and certain HLA-B antigens was found. | Human | VEGFA | 7422 | vascular endothelial growth factor A | VEGF levels may be regarded as a good indicator of active psoriasis arthritis | Human | TNF | 7124 | tumor necrosis factor | Title:Analysis of 6 genetic loci for disease susceptibility in psoriatic arthritis.|Association:Not Found|Conclusion:We identified an association between psoriatic arthritis and one of the microsatellite markers within the TNFB locus at the HLA region on chromosome 6. Linkage disequilibrium between TNFB123 and certain HLA-B antigens was found. promoter polymorphisms associated with psoriasis vulgaris and psoriatic arthritis but not with pustulosis palmoplantaris An association between young age of onset of psoriasis and HLA-Cw*0602 is confirmed in patients with psoriatic arthritis While the previously reported association between TNF*-238A and psoriasis seems to primarily reflect linkage disequilibrium with PSORS1, TNF*-857T may represent a risk factor for psoriatic arthritis that is independent of the PSORS1 allele | Human | SOD2 | 6648 | superoxide dismutase 2, mitochondrial | Title:Manganese superoxide dismutase gene polymorphisms in psoriatic arthritis.|Association:Y|Conclusion:Therefore, MnSOD 1183C polymorphisms may be a precipitating factor for the development of psoriatic arthritis. | Human | S100A12 | 6283 | S100 calcium binding protein A12 | Data suggest that S100 proteins calprotectin and S100A12 are related to radiographic changes rather than disease activity in psoriatic arthritis with low disease activity | Human | PSORS2 | 5722 | psoriasis susceptibility 2 | PSORS2 alleles are not susceptibility factors in arthritis psoriatic patients of Italian origin | Human | PRL | 5617 | prolactin | the -1149G/T single nuceotide polymorphism of the extrapituitary prolactin promoter is not associated with psoriatic arthritis | Human | LTA | 4049 | lymphotoxin alpha | We identified an association between psoriatic arthritis and one of the microsatellite markers within the TNFB locus at the HLA region on chromosome 6 | Human | KIR2DS1 | 3806 | killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1 | An increase in the frequency of the activating KIR2DS1 gene was detected in the psoriatic arthritis (PsA) patients, compared with psoriasis patients negative for PsA and an unaffected American Caucasian control group Title:|Association:Not Found|Conclusion:Not Found | Human | KIR2DL3 | 3804 | killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3 | Title:|Association:Not Found|Conclusion:Not Found | Human | KIR2DL2 | 3803 | killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2 | Title:|Association:Not Found|Conclusion:Not Found | Human | KIR2DL1 | 3802 | killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1 | Title:|Association:Y|Conclusion:Not Found | Human | IL12B | 3593 | interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) | Variation within IL23R and IL12B is associated with susceptibility to both psoriasis and psoriatic arthritis | Human | IL4R | 3566 | interleukin 4 receptor | our data indicate that the AA genotype of the IL4R 150V SNP is associated with joint erosions in psoriatic arthritis | Human | IL1B | 3553 | interleukin 1, beta | The IL1 locus appears to be a high-priority susceptibility locus in psoriatic arthritis (PsA), with at least 2 independent regions that confer increased risk | Human | HLA-DRB4 | 3126 | | No definite association was found between HLA-DR alleles and the risk of psoriasis or psoriatic arthritis | Human | HLA-DRB1 | 3123 | | Title:[The distribution of HLA alleles class I and class II among patientes with psoriatic arthritis in Croatia]|Association:Y|Conclusion:The strongest association between psoriatic arthritis and HLA in the Croatian population was observed for alleles at HLA-B locus (B*39 and B*57), while the association of B*27 and B* 13 alleles with PsA reached significance only before correction of p value with the number of tested alleles. Higher frequency of Cw*02 and DRB1*16 alleles is a result of linkage disequilibrium between these alleles and HLA-B alleles associated with PsA in Croatia. We also observed lower frequency of B*0702, B*18 and B*38 alleles in our group of patients. | Human | HLA-C | 3107 | | Title:[The distribution of HLA alleles class I and class II among patientes with psoriatic arthritis in Croatia]|Association:Y|Conclusion:The strongest association between psoriatic arthritis and HLA in the Croatian population was observed for alleles at HLA-B locus (B*39 and B*57), while the association of B*27 and B* 13 alleles with PsA reached significance only before correction of p value with the number of tested alleles. Higher frequency of Cw*02 and DRB1*16 alleles is a result of linkage disequilibrium between these alleles and HLA-B alleles associated with PsA in Croatia. We also observed lower frequency of B*0702, B*18 and B*38 alleles in our group of patients. Title:[The Study of HLA-Cw Polymorphism in Uygur Population.]|Association:Not Found|Conclusion:We have made a survey of HLA-Cw alleles frequencies in a Uygur population,with blank frequency being lowered to 0.0064.The distribution of genotype frequencies met the law of Hardy-Weinberg equilibrium by hi-square test.The frequency data can be used in forensic and paternity tests to estimate the frequency of a DNA profile in the Uygur population,transplant matching and anthropology. |
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