Genes (31)
Species: human : 31 | |
Human | RETN | 56729 | resistin | Anorexia nervosa is associated with decreased plasma resistin levels circulating resistin levels do not appear to be closely related to the nutritional status in anorexia nervosa polymorphisms in adiponectin and resistin genes can contribute to metabolic phenotype of patients with obesity and anorexia nervosa | Human | GHRL | 51738 | ghrelin/obestatin prepropeptide | Underweight anorexia nervosa patients are characterized by increased concentrations of ghrelin and obestatin and a higher ghrelin to obestatin ratio: No such changes occur in women wigh bulimia nervoa acute plasma ghrelin response to food intake, which in healthy individuals is independent of meal caloric value, is impaired in women with anorexia nervosa Ghrelin secretion predicts bone density independent of body composition, the GH-IGF-I axis, cortisol, or estradiol in healthy girls but not in those with anorexia nervosa ghrelin is increased in anorexia nervosa and constitutionally thin subjects who display very low BMI but different eating behaviors, suggesting that not only is ghrelin dependent on body fat mass, but it is also influenced by nutritional status results suggest that both body mass index and the presence of binge-eating/purging may have some influence on fasting plasma ghrelin levels in patients with anorexia nervosa | Human | FGF21 | 26291 | fibroblast growth factor 21 | reduced plasma FGF21 levels could be involved in the pathophysiology of anorexia nervosa or in a complex adaptive response to this disease | Human | CLOCK | 9575 | clock circadian regulator | polymorphism of the CLOCK gene confers a predisposition to a lifetime lower body weight in patients with anorexia nervosa and bulimia nervosa | Human | ADIPOQ | 9370 | adiponectin, C1Q and collagen domain containing | increased adiponectin levels reflect decreased body fat content in anorexia nervosa patients polymorphisms in adiponectin and resistin genes can contribute to metabolic phenotype of patients with obesity and anorexia nervosa Anorexia nervosa is associated with increased plasma adiponectin levels | Human | UCP3 | 7352 | uncoupling protein 3 (mitochondrial, proton carrier) | microsatellite markers at the UCP2/UCP3 locus on chromosome 11q13 in anorexia nervosa | Human | UCP2 | 7351 | uncoupling protein 2 (mitochondrial, proton carrier) | microsatellite markers at the UCP2/UCP3 locus on chromosome 11q13 in anorexia nervosa | Human | TNF | 7124 | tumor necrosis factor | Interleukin-6, tumor necrosis factor alpha and interferon gamma serum levels in patients with anorexia nervosa TNF-alpha -308 G to A TNF-alpha gene promoter polymorphism at position -308 might be associated with a predisposition to anorexia nervosa and initiate the disease | Human | SLC6A4 | 6532 | solute carrier family 6 (neurotransmitter transporter), member 4 | Title:Serotonin transporter regulatory region polymorphism is associated with anorexia nervosa|Association:Y|Conclusion:The 5-HTTLPR S allele might play some role in the development of AN with persistent disease. Title:Association of a functional 5-HT transporter gene polymorphism with anorexia nervosa and food intake.|Association:Y|Conclusion:There is a great consistency between our results and the in vitro effects of the S allele. The effects of the S allele are quite similar to that of serotonergic anorectic drugs inhibitiing reuptake of the 5-HT. However, the effects observed here may be secondary to behavioral or psychological traits possibly associated with this polymorphism. evidence in support of interaction between the MAOA and serotonin transporter (SERT) genes in 114 anorexia nervosa nuclear families (patient with AN plus biological parents) No association of 5-HTTLPR with personality dimensions in anorexia nervosa patients was observed | Human | SLC6A2 | 6530 | solute carrier family 6 (neurotransmitter transporter), member 2 | Anorexia nervosa (restrictive subtype) is associated with a polymorphism in the promoter polymorphic region | Human | SHBG | 6462 | sex hormone-binding globulin | serum concentrations are elevated in kwashiorkor and anorexia nervosa but not in marasmus; marker of nutritional status in anorexia nervosa and kwashiorkor | Human | PYY | 5697 | peptide YY | no role for abnormal circulating PYY in human obesity but circulating PYY levels in humans are significantly elevated in anorexia nervosa Elevated PYY may contribute to reduced intake and decreased bone turnover in anorexia nervosa | Human | OPRD1 | 4985 | opioid receptor, delta 1 | Gene may be linked to etiology of anorexia nervosa | Human | NTRK2 | 4915 | neurotrophic tyrosine kinase, receptor, type 2 | Contribution of NTRK2 to the genetic susceptibility of eating disorders, mainly anorexia nervosa, harm avoidance and body mass index | Human | MC3R | 4159 | melanocortin 3 receptor | Single-nucleotide polymorphisms found in anorexia nervosa | Human | MAOA | 4128 | monoamine oxidase A | evidence in support of interaction between the MAOA and serotonin transporter (SERT) genes in 114 anorexia nervosa nuclear families (patient with AN plus biological parents) | Human | LEPR | 3953 | leptin receptor | Expression levels of leptin receptor-coding gene showed significant differences between anorexia nervosa (AN)-binge/purge type and AN-restricting (R) type patients and between AN-R and control subjects Leptin receptor SNPs do not appear to be important factors in the regulation of body weight in young, pre-menopausal women or have any significant association with anorexia nervosa | Human | LEP | 3952 | leptin | Anorexia nervosa is associated with decreased plasma leptin levels review the effects of leptin and orexins in anorexia nervosa [review] the influence of leptin on gonadotropin secretion is demonstrated in female adolescents with anorexia nervosa during starvation and re-feeding The purpose of this study was to investigate basal serum levels of OPG, RANKL and leptin, as well as bone mineral density (BMD) at lumbar vertebrae L1-L4, and their evolution during one year in two groups of patients with anorexia nervosa and osteopenia | Human | KCNN3 | 3782 | potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 | Title:|Association:Y|Conclusion:Not Found Title:CAG repeat polymorphism within the KCNN3 gene is a significant contributor to susceptibility to anorexia nervosa: a case-control study of femalepatients and several ethnic groups in the Israeli Jewish population.|Association:Y|Conclusion:These findings further implicate KCNN3 as a significant contributor to predisposition to AN | Human | KCNK3 | 3777 | potassium channel, subfamily K, member 3 | Title:Association between anorexia nervosa and the hsKCa3 gene: a family-based and case control study.|Association:Not Found|Conclusion:Our study suggests that the longer repeat alleles of the hSKCa3 gene may contribute to the genetic susceptibility to AN. | Human | HTR2C | 3358 | 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled | The findings are consistent a role for the Ser23 allele of 5-HT2c in mediating susceptibility to and increasing severity of anorexia nervosa | Human | HTR2A | 3356 | 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled | Title:The human genetics of anorexia nervosa.|Association:Not Found|Conclusion:We thus propose a meta-analysis showing that a large heterogeneity between samples exists, but the main effect of the -1438A allele persists even when extracting this contaminating effect (p=0.003). Furthermore, the absence of significant correlation between odds ratio and time after first publication of each sample, and size of each sample, is in accordance with the fact that the A allele is a risk factor. In order to explain the high heterogeneity between the nine studies yet performed, an alternative explanation such as a "modifying the phenotype" effect is proposed. Title:5-HT(2A) gene promoter polymorphism as a modifying rather than a vulnerability factor in anorexia nervosa.|Association:Not Found|Conclusion:Taking into account vulnerability genes, but also genes modifying the expression of the disorder, will help to disentangle the complexity of the etiological factors involved in anorexia nervosa. A multicenter European family-based transmission disequilibrium study found no evidence for a significant role of the 5-HT(2A) gene in anorexia nervosa promoter region of the 5-HT2A receptor gene does not contribute to a predisposition to anorexia nervosa for Japanese The A allele of the 5-HT 2A gene has bee associated with anorexia nervosa No allele differences were detected regardless of whether the bulimia nervosa patients had suffered prior anorexia nervosa episodes | Human | GCG | 2641 | glucagon | low secretion of GLP-1 in girls with obesity may seriously and negatively influence the course of this disease while low levels in girls with anorexia nervosa are beneficial and promote appetite | Human | ESR2 | 2100 | estrogen receptor 2 (ER beta) | Title:Variation in the ESR1 and ESR2 genes and genetic susceptibility to anorexia nervosa.|Association:Not Found|Conclusion:Analysis of haplotypes at ESR1 and ESR2 showed no significant evidence of association with AN suggesting that the variability in ESR2 alone may contribute to the genetic susceptibility to AN. | Human | DRD4 | 1815 | dopamine receptor D4 | tested association for 5 DRD4 polymorphic loci, 3 promoter region SNPs (C-521T, C-616G, A-809G), the 120 bp promoter region tandem duplication and the exon III repeat, in 202 anorexia nervosa trios and 418 control families |
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