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Details
Link-It Detail - Disease - Amyloidosis
Debug Stats
  • ### Total Build Time: 532 ms 66.511 KB
  • CONCEPT_NAME gt=9 ms Completed: 9 ms rowSize= 320 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 660 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=2 ms Completed: 2 ms rowSize= 188 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=0 Completed: 0 ms rowSize= 561 bytes
  • CONCEPT_CHILDREN gt=7 ms Completed: 7 ms rowSize= 1.409 KB
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 1.524 KB
  • CONCEPT_RELATIONSHIPS gt=470 ms Completed: 470 ms rowSize= 14.914 KB
  • CONCEPT_GENES gt=38 ms Completed: 38 ms rowSize= 45.802 KB
  • CONCEPT_XREFS gt=4 ms Completed: 4 ms rowSize= 1.146 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Amyloidosis C0002726
Definition (1)

Amyloidosis occurs when abnormal proteins build up and form deposits. The deposits can collect in organs such as the kidney and heart. This can cause the organs to become stiff and unable to work the way they should.

There are three main types of amyloidosis:

  • Primary - with no known cause
  • Secondary - caused by another disease, including some types of cancer
  • Familial - passed down through genes

Treatment depends on the type of amyloidosis you have.

Semantic Types (1)
Disease or Syndrome (T047)
Parents (1)
img Proteostasis Deficiencies C2718000
Children (3)
img Amyloidosis, Familial C0740340
img Amyloid Neuropathies C0206247
img Cerebral Amyloid Angiopathy C0085220
Ancestral Roots
RootRoot Plus OneDepthParent
img Nutritional and Metabolic Diseases C0028715img Metabolic Diseases C00255174img Proteostasis Deficiencies C2718000
Relationships (197)

Relation Types:
diso_​to_​anat : 9
diso_​to_​chem : 56
diso_​to_​diso : 124
diso_​to_​gene : 4
diso_​to_​phen : 2
diso_​to_​phys : 2


Relationships:
none : 116
associated_​with : 3
gene_​associated_​with_​disease : 4
gene_​product_​malfunction_​associated_​with_​disease : 2
is_​finding_​of_​disease : 2
isa : 14
mapped_​to : 38
may_​treat : 15
related_​to : 2
used_​for : 1
Page Size
Current 25
  Page 1 of 8
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_DISO543img Complication Aspects C1171258
DISO_to_DISO447img Complication Aspects C1171258
DISO_to_PHEN165img genetic aspects C0017399
DISO_to_PHEN160img genetic aspects C0017399
DISO_to_CHEM158img Amyloid C0002716
DISO_to_CHEM157img Amyloid C0002716
DISO_to_CHEM111img Chains, Immunoglobulin Light C0021038
DISO_to_CHEM111img Immunoglobulin Light Chains C0021038
DISO_to_DISO109img Kidney Diseases C0022658
DISO_to_DISO99img Cardiomyopathies C0878544
DISO_to_DISO99img Multiple Myeloma C0026764
DISO_to_DISO95img Heart Diseases C0018799
DISO_to_ANAT90img In Blood C0005768
DISO_to_DISO90img Kidney Diseases C0022658
DISO_to_DISO73img Cardiomyopathies C0878544
DISO_to_CHEM72img Prealbumin C0032923
DISO_to_CHEM72img Serum Amyloid A Protein C0002723
DISO_to_CHEM72img Serum amyloid A protein C0002723
DISO_to_DISO64img Multiple Myeloma C0026764
DISO_to_ANAT63img In Blood C0005768
DISO_to_CHEM60img Serum Amyloid A Protein C0002723
DISO_to_DISO60img Alzheimer Disease C0002395
DISO_to_DISO59img Skin Diseases C0037274
DISO_to_DISO56img Arthritis, Rheumatoid C0003873
DISO_to_DISO55img Arthritis, Rheumatoid C0003873
Genes (40)

Species:
human : 40
Page Size
Current 25
  Page 1 of 2
Prior Page
Current 1
SpeciesGeneGeneIdGene NameEvidence
HumanLOC643387643387TAR DNA binding protein pseudogene
img GENERIF, Score=861, Pubmed Id: 17936612, UMLKSK CUI: C0002726
HumanNLRP3114548NLR family, pyrin domain containing 3
img GAD, Score=1000, Pubmed Id: 15071491, UMLKSK CUI: C0002726
HumanHAMP57817hepcidin antimicrobial peptide
INFERRED, Score=800, UMLKSK CUI: C0002726
HumanGAL51083galanin/GMAP prepropeptide
img GENERIF, Score=1000, Pubmed Id: 15893372, UMLKSK CUI: C0002726
HumanHSPB826353heat shock 22kDa protein 8
img GENERIF, Score=1000, Pubmed Id: 16485107, UMLKSK CUI: C0002726
HumanTTR7276transthyretin
img GENERIF, Score=1000, Pubmed Id: 14507924, UMLKSK CUI: C0002726
img GENERIF, Score=1000, Pubmed Id: 11106758, UMLKSK CUI: C0002726
img GENERIF, Score=1000, Pubmed Id: 17062384, UMLKSK CUI: C0002726
img GENERIF, Score=861, Pubmed Id: 16219761, UMLKSK CUI: C0002726
img GENERIF, Score=660, Pubmed Id: 12560553, UMLKSK CUI: C0002726
img GENERIF, Score=861, Pubmed Id: 17980738, UMLKSK CUI: C0002726
img GAD, Score=833, Pubmed Id: 1978774, UMLKSK CUI: C0002726
HumanTNFRSF1A7132tumor necrosis factor receptor superfamily, member 1A
img GAD, Score=1000, Pubmed Id: 15071491, UMLKSK CUI: C0002726
img GAD, Score=1000, Pubmed Id: 12105243, UMLKSK CUI: C0002726
HumanTNF7124tumor necrosis factor
img GENERIF, Score=1000, Pubmed Id: 12762136, UMLKSK CUI: C0002726
img GAD, Score=1000, Pubmed Id: 14696796, UMLKSK CUI: C0002726
HumanSOD16647superoxide dismutase 1, soluble
img GENERIF, Score=1000, Pubmed Id: 16798882, UMLKSK CUI: C0002726
HumanSNCA6622synuclein, alpha (non A4 component of amyloid precursor)
img GENERIF, Score=827, Pubmed Id: 18704197, UMLKSK CUI: C0002726
img GENERIF, Score=861, Pubmed Id: 18261982, UMLKSK CUI: C0002726
img GENERIF, Score=983, Pubmed Id: 12124613, UMLKSK CUI: C0002726
HumanSEMG16406semenogelin I
img GENERIF, Score=1000, Pubmed Id: 15962837, UMLKSK CUI: C0002726
HumanSAA26289serum amyloid A2
img GENERIF, Score=1000, Pubmed Id: 15170927, UMLKSK CUI: C0002726
HumanSAA16288serum amyloid A1
img GAD, Score=1000, Pubmed Id: 16219644, UMLKSK CUI: C0002726
img GENERIF, Score=1000, Pubmed Id: 17039260, UMLKSK CUI: C0002726
img GAD, Score=1000, Pubmed Id: 14696796, UMLKSK CUI: C0002726
img GAD, Score=1000, Pubmed Id: 16011988, UMLKSK CUI: C0002726
img GENERIF, Score=1000, Pubmed Id: 15972323, UMLKSK CUI: C0002726
HumanRBP45950retinol binding protein 4, plasma
INFERRED, Score=800, UMLKSK CUI: C0002726
HumanPTGS25743prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
img GENERIF, Score=1000, Pubmed Id: 12450219, UMLKSK CUI: C0002726
HumanPSEN15663presenilin 1
INFERRED, Score=800, UMLKSK CUI: C0002726
HumanPON15444paraoxonase 1
INFERRED, Score=800, UMLKSK CUI: C0002726
HumanFURIN5045furin (paired basic amino acid cleaving enzyme)
INFERRED, Score=800, UMLKSK CUI: C0002726
HumanMME4311membrane metallo-endopeptidase
img GENERIF, Score=1000, Pubmed Id: 12657655, UMLKSK CUI: C0002726
HumanMEFV4210Mediterranean fever
img GENERIF, Score=1000, Pubmed Id: 18353061, UMLKSK CUI: C0002726
img GENERIF, Score=1000, Pubmed Id: 17102945, UMLKSK CUI: C0002726
img GENERIF, Score=1000, Pubmed Id: 12401847, UMLKSK CUI: C0002726
img GENERIF, Score=1000, Pubmed Id: 18061974, UMLKSK CUI: C0002726
img GENERIF, Score=1000, Pubmed Id: 16627024, UMLKSK CUI: C0002726
img GAD, Score=1000, Pubmed Id: 11175300, UMLKSK CUI: C0002726
img GENERIF, Score=1000, Pubmed Id: 12687559, UMLKSK CUI: C0002726
img GAD, Score=1000, Pubmed Id: 15071491, UMLKSK CUI: C0002726
img GAD, Score=1000, Pubmed Id: 12105243, UMLKSK CUI: C0002726
img GENERIF, Score=1000, Pubmed Id: 18266121, UMLKSK CUI: C0002726
HumanMBP4155myelin basic protein
INFERRED, Score=800, UMLKSK CUI: C0002726
HumanMBL24153mannose-binding lectin (protein C) 2, soluble
img GENERIF, Score=861, Pubmed Id: 17875183, UMLKSK CUI: C0002726
HumanMAZ4150MYC-associated zinc finger protein (purine-binding transcription factor)
img GENERIF, Score=812, Pubmed Id: 16888022, UMLKSK CUI: C0002726
HumanMAG4099myelin associated glycoprotein
img GENERIF, Score=861, Pubmed Id: 18236455, UMLKSK CUI: C0002726
HumanLYZ4069lysozyme
img GENERIF, Score=1000, Pubmed Id: 16441658, UMLKSK CUI: C0002726
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0002726Amyloidosis0self